Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a bas ....Nanosilver antimicrobial resistance in target pathogens. This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a base template for novel nanosilver engineering with less tendency for resistance development and to facilitate tracking of resistance and its spread amongst microorganisms. The knowledge has far-reaching implications on the better governance of nanosilver use, including its disposal.Read moreRead less
The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling f ....The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm. The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.Read moreRead less
Nanoengineering of Biomaterial Surfaces to Tailor Innate Immune Responses. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Recently, we showed that surface nanotopography induced conformational changes in adsorbed proteins can activate or deactivate immune cells. These exciting findings are important because they show that it may be possible to engineer the nanotopography of a biomedical device surface in ....Nanoengineering of Biomaterial Surfaces to Tailor Innate Immune Responses. The overarching aim of this project is to provide a mechanistic understanding of how surface nanotopography affects inflammatory responses. Recently, we showed that surface nanotopography induced conformational changes in adsorbed proteins can activate or deactivate immune cells. These exciting findings are important because they show that it may be possible to engineer the nanotopography of a biomedical device surface in a manner which leads to a desired and predictable level of inflammation. The outcomes of the project will create new fundamental knowledge that in the future can instruct the development of the next generation of biomaterials capable of controlling and directing the body’s inflammatory responses.Read moreRead less
Investigating a novel, physical adjuvant for improving immune responses of vaccines. This project will explore a new way to significantly improve vaccine immune responses: with practical devices that apply pressure on the skin - for the body to create its own, localised adjuvant. This is novel - completely different to today's adjuvants, which are chemicals put into our bodies.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less