Material boundaries in ultrasonics: New methods and in vitro studies in biomedical phantoms. Ultrasound is an indispensable part of healthcare worldwide. The next wave of applications will see ultrasound pulses used to closely probe suspected disease sites and to directly manipulate bioactive agents. For safe and effective use of such techniques it is essential to know the ultrasound field at the disease site. This project will develop simulation methods to achieve the fast, accurate and case-sp ....Material boundaries in ultrasonics: New methods and in vitro studies in biomedical phantoms. Ultrasound is an indispensable part of healthcare worldwide. The next wave of applications will see ultrasound pulses used to closely probe suspected disease sites and to directly manipulate bioactive agents. For safe and effective use of such techniques it is essential to know the ultrasound field at the disease site. This project will develop simulation methods to achieve the fast, accurate and case-specific results required. Community healthcare will benefit, through better diagnostic capabilities and customized treatment. Australia is well placed to profit further from this research, in view of the growing worldwide demand for more sophisticated, knowledge-based techniques in medicine.Read moreRead less
The effect of vessel wall structures on ultrasonic flow velocity measurements. The flow velocity within a nearly cylindrical vessel is often measured using an external ultrasound transducer via the Doppler principle. Thick vessel walls may present acoustically mismatched structures. This project aims to determine how such walls redistribute the energy in an interrogating ultrasound beam, and how this in turn affects the measurement of flow velocities. This is a fundamental issue, especially imp ....The effect of vessel wall structures on ultrasonic flow velocity measurements. The flow velocity within a nearly cylindrical vessel is often measured using an external ultrasound transducer via the Doppler principle. Thick vessel walls may present acoustically mismatched structures. This project aims to determine how such walls redistribute the energy in an interrogating ultrasound beam, and how this in turn affects the measurement of flow velocities. This is a fundamental issue, especially important in vascular disease where blood flow and blood vessels are affected by wall irregularities and lesions. The new knowledge generated by this project will have practical importance and, by identifying achievable outcomes, potentially major cost savings, in medical ultrasound.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347727
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Computational infrastructure for high-throughput genome bioinformatics. We propose a high-performance computing and web facility for genome bioinformatics. It will provide a common software development environment in support of molecular biosciences, systems biology and complex systems modelling at the Institute for Molecular Bioscience at University of Queensland, and at Queensland University of Technology. The platform will support Australia's first genome-scale bioinformatics research website ....Computational infrastructure for high-throughput genome bioinformatics. We propose a high-performance computing and web facility for genome bioinformatics. It will provide a common software development environment in support of molecular biosciences, systems biology and complex systems modelling at the Institute for Molecular Bioscience at University of Queensland, and at Queensland University of Technology. The platform will support Australia's first genome-scale bioinformatics research website, with unique software and mirrors of the IBM Biological Pattern Discovery, UC San Diego MEME/MetaMEME/MAST, and NGI comparative genomics websites. Australian/NZ researchers will access the facility at no cost for high-throughput use of unique software, website mirrors and other important tools for genome bioinformatics.Read moreRead less
Security Applications of Combinatorial Puzzles. This project provides a basis for improving the implementation and maintenance of key management systems. The application of discrete mathematics to information security will help safeguard Australia, will provide opportunities for Australians to take a leading role in an important area and will develop a research network, bridging both theoretical and practical aspects of mathematics and computer science. The project will enhance Australia's inter ....Security Applications of Combinatorial Puzzles. This project provides a basis for improving the implementation and maintenance of key management systems. The application of discrete mathematics to information security will help safeguard Australia, will provide opportunities for Australians to take a leading role in an important area and will develop a research network, bridging both theoretical and practical aspects of mathematics and computer science. The project will enhance Australia's international reputation by establishing collaborations with well-respected international mathematicians and computer scientists. The proposal contains topics suitable for the training of new graduates, allowing them to make high quality original research contributions in a novel and important area. Read moreRead less
Timed Commitment Schemes to Smooth Internet Bottlenecks, Defend against Denial of Service Attacks, and Bypass Some Legal Problems of Enccryption. Bottlenecks on the Internet and Denial of Service attacks on a server are both caused by excessive demands made on a system. This proposal is to reduce the ill-effects of either by building on our previous theoretical work on strongboxes of combinatorial designs. In the case of bottlenecks, the demands are legitimate but badly timed, and our approach ....Timed Commitment Schemes to Smooth Internet Bottlenecks, Defend against Denial of Service Attacks, and Bypass Some Legal Problems of Enccryption. Bottlenecks on the Internet and Denial of Service attacks on a server are both caused by excessive demands made on a system. This proposal is to reduce the ill-effects of either by building on our previous theoretical work on strongboxes of combinatorial designs. In the case of bottlenecks, the demands are legitimate but badly timed, and our approach will redistribute the demands more evenly. In the case of Denial of Service attacks, the demands are malicious, and our approach will respond in such a way as to deplete the resources of the attacker.Read moreRead less
Yield strength and plastic flow of heterogeneous materials: Designing optimal composites and porous materials. A major goal of materials science is to design materials with improved functionality at lower weight, cost and size. It is important to guide this expensive and time-consuming process with sophisticated computer modelling. In this project we aim to model how and why composite and porous materials fail when they are placed under stress. Our results will make materials design more efficie ....Yield strength and plastic flow of heterogeneous materials: Designing optimal composites and porous materials. A major goal of materials science is to design materials with improved functionality at lower weight, cost and size. It is important to guide this expensive and time-consuming process with sophisticated computer modelling. In this project we aim to model how and why composite and porous materials fail when they are placed under stress. Our results will make materials design more efficient by providing a valuable experimental interpretive tool and a theoretical map for material optimization. Our models will also provide crucial information needed for modelling the behavior of composites in applications.Read moreRead less
How do macroeconomic fluctuations affect the educational choices of young Australians? The 1990-1991 recession, recent evidence, and econometric issues. The educational choices of young people are crucial for any nation's future. The project's empirical findings will inform public policy, particularly in the areas of education and training and youth unemployment. The research will help policy makers target people who need extra support in tough times and help determine the demand for different k ....How do macroeconomic fluctuations affect the educational choices of young Australians? The 1990-1991 recession, recent evidence, and econometric issues. The educational choices of young people are crucial for any nation's future. The project's empirical findings will inform public policy, particularly in the areas of education and training and youth unemployment. The research will help policy makers target people who need extra support in tough times and help determine the demand for different kinds of education. The findings have implications for future policies aimed at reducing inequality. The project's methodological contributions will lead to better and more reliable research in economics and other fields such as biology and engineering. The findings will be suitable for the top economics journals and contribute to Australia's standing in the academic community.Read moreRead less
Efficient Operation of Bioreactors using Nonlinear Dynamical Systems Theory. Current methods of determining optimal operating conditions in bioreactors have recently been shown to be inefficient, resulting in serious omissions of crucial parameter regions. We will use mathematical techniques from dynamical systems theory to establish a general framework by which bioreactor systems can be efficiently and systematically investigated to improve reactor performance. By communicating these results at ....Efficient Operation of Bioreactors using Nonlinear Dynamical Systems Theory. Current methods of determining optimal operating conditions in bioreactors have recently been shown to be inefficient, resulting in serious omissions of crucial parameter regions. We will use mathematical techniques from dynamical systems theory to establish a general framework by which bioreactor systems can be efficiently and systematically investigated to improve reactor performance. By communicating these results at relevant fora, we will increase the awareness within the Australian and international engineering communities of the advantages of modern mathematical techniques. Although this proposal focuses on bioreactors, the techniques can be easily adapted to improve the performances of other chemical processes.
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Analysing Instabilities in Complex Combustion Models for Different Geometrical Configurations. Anyone who has gazed into a fire will appreciate the complexity of combustion. To date only the simplest of models have been comprehensively analysed. This project, which aims to analyse more complex combustion models, will address some of the fundamental issues of combustion theory. Results from this project will lead to a better understanding of combustion processes, with the potential to prevent exp ....Analysing Instabilities in Complex Combustion Models for Different Geometrical Configurations. Anyone who has gazed into a fire will appreciate the complexity of combustion. To date only the simplest of models have been comprehensively analysed. This project, which aims to analyse more complex combustion models, will address some of the fundamental issues of combustion theory. Results from this project will lead to a better understanding of combustion processes, with the potential to prevent explosions in reactors and storage tanks. Other potential applications range from bushfires to the manufacture of exotic materials. Furthermore, the novel mathematical techniques developed in this project can be easily adapted to other types of systems such as those used in biology (eg. epidemiology and tumour growth), economics, physics etc. Read moreRead less
Viscous Effects in Free-Surface Flows. Australia has a proud record of achievement in the field of free-surface fluid mechanics. This project will build and extend these research achievements. It will provide new information about how fluid layers overturn and mix, which is an important process in oceanography. It will examine the sloshing behaviour of fluid in moving storage tanks, which is important in fuel transport and building design. The project will develop new mathematical methods fo ....Viscous Effects in Free-Surface Flows. Australia has a proud record of achievement in the field of free-surface fluid mechanics. This project will build and extend these research achievements. It will provide new information about how fluid layers overturn and mix, which is an important process in oceanography. It will examine the sloshing behaviour of fluid in moving storage tanks, which is important in fuel transport and building design. The project will develop new mathematical methods for solving these problems accurately, and will contribute to the next generation of research mathematicians in Australia. Read moreRead less