Using Good Measurement Principles To Examine Musculoskeletal Disease And Improve The Evaluation Of New Diagnostic Tests
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
This proposal will apply good measurement principles to 2 important but under-resourced areas: 1) To examine risk factors for musculoskeletal disease (particularly osteoarthritis or “wear and tear” arthritis) and to determine how changes in these risk factors in our community will affect the burden of disease, thus identifying new targets for disease prevention. 2) To improve our ability to evaluate how well new diagnostic tests function when introduced into our healthcare system.
Advanced Technologies For Improved Molecular Diagnostic And Prognostic Of Gastrointestinal Cancers
Funder
National Health and Medical Research Council
Funding Amount
$473,477.00
Summary
The aim of this interdisciplinary research is to develop innovative and clinically relevant technologies for improved molecular diagnostic of gastrointestinal cancers. It integrates technological advances in physics, bioengineering and nanoscience with state-of-the-art molecular technologies towards the delivery of both fundamental and translational outcomes. These technologies will be applied to address important fundamental questions such as the role of circulating tumour cells.
Refining Methods For Obtaining, Synthesising And Interpreting Research Evidence In Surgery
Funder
National Health and Medical Research Council
Funding Amount
$314,312.00
Summary
Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information need ....Research evidence plays a crucial role in improving clinical care. However the main forms of evidence and the tools that facilitate evidence use - namely randomised controlled trials (RCT) and structured systematic reviews of existing research - have had limited application in surgery for a variety of reasons. This project aims to promote the use of research evidence in surgical decision making by developing tools tailored to the predominance of non-RCTs in surgery and surgeons' information needs.Read moreRead less
My research objectives centre on new technology development for improving diagnostics and therapeutics applied to skin. I have developed and patented novel devices for minimally invasive topical drug delivery and skin sampling. My leadership and tangible research outcomes are now enabling previously impossible skin research to be done and now are also impacting the commercial sector in addition to creating new knowledge in the field.
This program of research will develop and evaluate improved strategies for communication and decision making in medical testing for consumers, patients and clinicians. Better understanding about medical tests and improved interventions to support decision making will enable patients and clinicians make more informed and more appropriate decisions about when and when not to test. This work forms part of a broader objective to build health literacy and shared health decision making in Australia.
Understanding The Regulation Of Cell Polarity In Development And Cancer
Funder
National Health and Medical Research Council
Funding Amount
$428,602.00
Summary
Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regulator of cell orientation, may keep tumour development in check. In this proposal, we will examine how disruption of Scribble and associated molecules affects normal development and promotes cancer using a combination of tissue culture studies and a newly established mouse model. These studies may provide novel targets for therapeutic intervention in cancer.
Vestibulo-ocular Reflex Physiology, Pathology And Diagnosis.
Funder
National Health and Medical Research Council
Funding Amount
$387,489.00
Summary
A sensation of movement from the inner ear is used to stabilise vision during head movements. Without it, every time you walk, run, or drive on a bumpy road, the world would appear to bounce. It can be debilitating when this sense doesn't work due to various diseases. This research examines what causes these disorders and how the brain responds to help recovery. A diagnostic technique, that we will develop for wide clinical use, will be used to assess and identify treatments.