Understanding the Influence of Cloud on the Spectral Solar Ultraviolet Radiation. Terrestrial spectral solar UV may be enhanced above that of clear sky due to certain cloud conditions. There is a major gap in the scientific knowledge of the influence of cloud on the spectral solar UV and resultant biologically damaging UV. This project will collect the only dataset of sky conditions and spectral UV for each ten minute period spanning 12 months to determine: the specific wavelengths with increase ....Understanding the Influence of Cloud on the Spectral Solar Ultraviolet Radiation. Terrestrial spectral solar UV may be enhanced above that of clear sky due to certain cloud conditions. There is a major gap in the scientific knowledge of the influence of cloud on the spectral solar UV and resultant biologically damaging UV. This project will collect the only dataset of sky conditions and spectral UV for each ten minute period spanning 12 months to determine: the specific wavelengths with increased irradiances; the amount of enhanced damaging UV; the cloud conditions that cause these enhancements and develop a predictive capability to determine when cloud cover will enhance solar UV.Read moreRead less
Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical ....Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical science, imaging and sensing. Important applications include the early detection of debilitating diseases and the advancement of understanding of cellular biology. This research will raise Australia's profile as a world leader in science and technology, building on our emerging presence in the biophysical sciences.Read moreRead less
The Effect of Fuel Type on Health and Environmental Risks Caused by Motor Vehicle Emissions. Motor vehicles constitute one of the most significant sources of air pollutants but the state of knowledge on the quantity of some of these does not permit for projection of the risk they create. This project aims at quantification of emissions of pollutants contributing to deterioration of health, ozone formation, global warming and acid rain as a function of fuel type, using a novel on-road sampling m ....The Effect of Fuel Type on Health and Environmental Risks Caused by Motor Vehicle Emissions. Motor vehicles constitute one of the most significant sources of air pollutants but the state of knowledge on the quantity of some of these does not permit for projection of the risk they create. This project aims at quantification of emissions of pollutants contributing to deterioration of health, ozone formation, global warming and acid rain as a function of fuel type, using a novel on-road sampling method. Resultantly, a holistic picture of integrated health and environmental risk will be developed that will build a scientific foundation for future fuel,transport and land use to protect the community and the environment.Read moreRead less
Development of a neutral helium beam microscope. This project would demonstrate Australia's capability in developing leading edge technologies applicable to the growing nanotechnology industry. The development of a neutral helium beam microscope brings into Australia expertise in the emerging field of molecular optics, and would place Australia as one of the first countries to make a commitment to this field. The project will develop a prototype instrument which is aimed at becoming a commercial ....Development of a neutral helium beam microscope. This project would demonstrate Australia's capability in developing leading edge technologies applicable to the growing nanotechnology industry. The development of a neutral helium beam microscope brings into Australia expertise in the emerging field of molecular optics, and would place Australia as one of the first countries to make a commitment to this field. The project will develop a prototype instrument which is aimed at becoming a commercially viable product - the neutral helium beam microscope. The possibilities of using the microscope system as a nanofabrication device would also give researchers in Australia the ability to fabricate structures that could not be manufactured anywhere else in the world.Read moreRead less
Developing orthogonal synthetic signaling cascades. This project proposes a generic approach for the construction of molecular switches based on artificially autoinhibited proteases. The bottom-up design of protein-based signaling networks is a key goal of synthetic biology. Yet, this remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Using structure-guided design and directed protein evolution, a set ....Developing orthogonal synthetic signaling cascades. This project proposes a generic approach for the construction of molecular switches based on artificially autoinhibited proteases. The bottom-up design of protein-based signaling networks is a key goal of synthetic biology. Yet, this remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Using structure-guided design and directed protein evolution, a set of protease-based signal transducers and ligand activated allosteric receptors will be created. The developed components are intended to be used to construct artificial signaling networks in mammalian cells that are orthogonal to the endogenous signaling cascades.Read moreRead less
Rotating Radiofrequency Phased-array for 7 Tesla Magnetic Resonance Imaging. This project aims to develop a new type of radiofrequency coil array to ensure high-field magnetic resonance imaging (MRI), with all its benefits, is available for a broader range of applications. High-field MRI offers faster scans with more detailed images than lower field systems. This enhanced sensitivity potentially enables smaller structures to be resolved in the body. At high fields, however, standard radiofrequen ....Rotating Radiofrequency Phased-array for 7 Tesla Magnetic Resonance Imaging. This project aims to develop a new type of radiofrequency coil array to ensure high-field magnetic resonance imaging (MRI), with all its benefits, is available for a broader range of applications. High-field MRI offers faster scans with more detailed images than lower field systems. This enhanced sensitivity potentially enables smaller structures to be resolved in the body. At high fields, however, standard radiofrequency coils, an essential component of MRI systems, can distort images and induce potentially harmful tissue heating. The aim is to design and develop a rotating multi-channel radiofrequency coil array, with dedicated image reconstruction software, to overcome these limitations. This would facilitate detailed images that can be obtained quickly and safely.Read moreRead less
Demonstrating the feasibility of designing sustainable buildings using evolutionary systems. The design approach proposed in this research will result in two key areas of national benefit. First, the research will enable Australian built environment design professions to become more competitive in both domestic and international markets. There is a growing demand for environmentally-friendly buildings and the proposed design approach will enable Australian firms to be at the cutting edge of sust ....Demonstrating the feasibility of designing sustainable buildings using evolutionary systems. The design approach proposed in this research will result in two key areas of national benefit. First, the research will enable Australian built environment design professions to become more competitive in both domestic and international markets. There is a growing demand for environmentally-friendly buildings and the proposed design approach will enable Australian firms to be at the cutting edge of sustainable design. Second, the research will enable the Australian built environment to become more sustainable. The proposed approach will enable buildings to be designed that perform well, that are cost effective and that minimise their environmental impact. Read moreRead less
Dielectric contrast imaging for 7 Tesla magnetic resonance applications. This project aims to develop novel radio-frequency (RF) technology, ensuring that the benefits of high-field magnetic resonance imaging (MRI) are available for a broader range of applications. This project will develop a new contrast mechanism directly related to the RF properties of individual tissue types, circumventing a limitation of intensity based imaging. This technology will enhance Australia’s global impact the dev ....Dielectric contrast imaging for 7 Tesla magnetic resonance applications. This project aims to develop novel radio-frequency (RF) technology, ensuring that the benefits of high-field magnetic resonance imaging (MRI) are available for a broader range of applications. This project will develop a new contrast mechanism directly related to the RF properties of individual tissue types, circumventing a limitation of intensity based imaging. This technology will enhance Australia’s global impact the development of imaging technology for healthcare, biomedical research and advanced diagnostics.Read moreRead less
Verified Emulation of Legacy Mission Computer Systems. Processor obsolescence is a serious maintenance problem for long-lived computer control systems in military aircraft and other critical applications. A promising solution is to interpose an emulator program between the original "legacy" software and a replacement processor. Unfortunately, no techniques exist for accurately verifying that this procedure preserves the original system's functional and timing behaviour. A particular challenge ....Verified Emulation of Legacy Mission Computer Systems. Processor obsolescence is a serious maintenance problem for long-lived computer control systems in military aircraft and other critical applications. A promising solution is to interpose an emulator program between the original "legacy" software and a replacement processor. Unfortunately, no techniques exist for accurately verifying that this procedure preserves the original system's functional and timing behaviour. A particular challenge is that processor emulations involve both legacy code and new subroutines, written in different programming languages. This project will enable verification of safety and mission-critical emulated systems by devising a multilingual modelling and reasoning formalism, based on program refinement theory.Read moreRead less
Advanced Magnetic Resonance Imaging at 7 Tesla: Resolving the fundamental radiofrequency field-tissue interaction problem at ultra-high field. Ultra-high-field Magnetic Resonance Imaging (MRI) systems offer the potential for faster, more accurate diagnostic imaging. However, current applications are limited by the fundamental challenge of strong interactions between the electromagnetic field and human tissues, which result in poor image quality and/or compromised patient safety. Using a novel, s ....Advanced Magnetic Resonance Imaging at 7 Tesla: Resolving the fundamental radiofrequency field-tissue interaction problem at ultra-high field. Ultra-high-field Magnetic Resonance Imaging (MRI) systems offer the potential for faster, more accurate diagnostic imaging. However, current applications are limited by the fundamental challenge of strong interactions between the electromagnetic field and human tissues, which result in poor image quality and/or compromised patient safety. Using a novel, subject-specific imaging approach, this research will design and develop an ultra-high-field radiofrequency technology capable of offering high-performance imaging without jeopardising patient safety. This research will lay the groundwork for the translation of ultra-high field MRI research into clinical practice, generating new capabilities for diagnostic technologies.Read moreRead less