Developing Salient Messages For Indigenous Tobacco Control In Rural Aboriginal Smokers
Funder
National Health and Medical Research Council
Funding Amount
$117,331.00
Summary
I am a General Practitioner with a keen interest in smoking cessation particularly for Aboriginal people, who have a high rate of smoking. Media messages are not to date being completely effective in this group, so I am investigating how to make more relevant and persuasive messages to support Indigenous smokers and their families (importantly pregnant smokers) to become smoke-free and encourage them to use effective treatments to do so.
Insulin resistance (the inability of ordinarily insulin-sensitive tissues such as muscle and adipose tissue to respond to insulin) contributes to a number of diseases including diabetes and obesity. A key metabolic step in these tissues is the uptake of glucose from the blood stream. This step is accelerated by insulin thus allowing efficient clearance of glucose from the bloodstream after a meal. Our laboratory has played a major role in showing that insulin regulates glucose uptake into muscle ....Insulin resistance (the inability of ordinarily insulin-sensitive tissues such as muscle and adipose tissue to respond to insulin) contributes to a number of diseases including diabetes and obesity. A key metabolic step in these tissues is the uptake of glucose from the blood stream. This step is accelerated by insulin thus allowing efficient clearance of glucose from the bloodstream after a meal. Our laboratory has played a major role in showing that insulin regulates glucose uptake into muscle and adipose tissue by stimulating the movement of a glucose transport protein from inside the cell to the cell surface (see http:--www.imb.uq.edu.au-groups-james-glut4 for an animated description of this process). The purpose of this proposal is to dissect the molecular mechanisms by which this glucose transporter can be held inside the cell in the absence of insulin and then allowed to be released from this site moving to the surface in the presence of insulin. Our studies over the past 5 years have brought us much closer to understanding this process in detail. The identification of the molecules responsible for this regulatory step will not only aid our understanding of this process but it will also provide a valuable target for development of therapeutic agents that can be used to combat insulin resistance.Read moreRead less
Dementia, moral agency and identity. The project aims to examine the ethical issues raised by dementia and the care of those with the condition. The project will examine and evaluate the capacities those with dementia retain for social agency, valuing and relationships. The project will test and refine theories of agency, identity and vulnerability in the light of the cognitive deficits accompanying dementia. The project will lead to the delivery of more efficient healthcare through the developm ....Dementia, moral agency and identity. The project aims to examine the ethical issues raised by dementia and the care of those with the condition. The project will examine and evaluate the capacities those with dementia retain for social agency, valuing and relationships. The project will test and refine theories of agency, identity and vulnerability in the light of the cognitive deficits accompanying dementia. The project will lead to the delivery of more efficient healthcare through the development of increased understandings of the relevant ethical considerations for treatment, and recommendations for new and ethical approaches to policy on dementia. It brings benefits to the well-being and relationships of those with this condition, their families and friends, and the professionals who care for them.Read moreRead less
Trust in a social and digital world. This project aims to provide a systematic and empirically-informed account of the way networks facilitate or hinder knowledge. Distinguishing on-line information from disinformation can be difficult. This task can be greatly assisted by networks of trusted peers, but figuring out who to trust is itself a challenge. Identifying, designing, and facilitating networks of trust is therefore an urgent task. By using the tools of social epistemology, virtue epistemo ....Trust in a social and digital world. This project aims to provide a systematic and empirically-informed account of the way networks facilitate or hinder knowledge. Distinguishing on-line information from disinformation can be difficult. This task can be greatly assisted by networks of trusted peers, but figuring out who to trust is itself a challenge. Identifying, designing, and facilitating networks of trust is therefore an urgent task. By using the tools of social epistemology, virtue epistemology, and network science, this project will identify how individuals should distribute their trust when embedded in epistemically hostile environments.Read moreRead less
Role Of IGF Binding Protein-3 (IGFBP-3) And IGFBP-5 As Modulators Of Nuclear Hormone Signalling
Funder
National Health and Medical Research Council
Funding Amount
$465,750.00
Summary
The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain ....The insulin-like growth factors are small proteins involved in the growth of most tissues. Their actions are regulated by binding to larger proteins (known as IGFBPs) in the bloodstream and outside the cell. However, some IGFBPs are also found inside cells, where they seem to carry out other functions. We believe that two of these binding proteins, IGFBP-3 and IGFBP-5, change the way cells respond to vitamin A and vitamin D. These two vitamins are important in cell growth and in the way certain cells perform specialised functions. In test-tube experiments, IGFBP-3 and IGFBP-5 interact directly with the receptors that regulate the effects of these hormones. If the same thing happens inside the cell, IGFBP-3 and IGFBP-5 could change the way these receptors respond to signals from outside the cell. We will investigate what effect these IGFBPs have in living cells and in whole animals and how this may relate to human disease. If we are able to understand how IGFBP-3 and IGFBP-5 affect the way cells respond to vitamin A and D, then we may be able to develop new ways to treat certain human diseases.Read moreRead less