Inequality, Trade, and Technology. This project aims to improve our understanding of the causes of rising income inequality in the world economy and in Australia since the early 1980s. We focus on the increasing building costs and imports of machinery as significant contributors to the increasing inequality. We hypothesize 1) that the increasing costs of buildings have reduced the demand for workers that are complementary to non-residential building capital; thus, reducing real wages; and 2) tha ....Inequality, Trade, and Technology. This project aims to improve our understanding of the causes of rising income inequality in the world economy and in Australia since the early 1980s. We focus on the increasing building costs and imports of machinery as significant contributors to the increasing inequality. We hypothesize 1) that the increasing costs of buildings have reduced the demand for workers that are complementary to non-residential building capital; thus, reducing real wages; and 2) that the marked increase in imports of machinery since the 1960s has reduced the demand for unskilled labour and widened the employment and wage gap between skilled and unskilled labour. Both factors may have driven the increasing inequality in Australia.
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Inequality and economic growth. This project aims to identify forces driving inequality. Piketty’s influential book, Capital in the 21st Century, stimulated research on inequality to address the increased public concern about inequality and its side-effects such as reduced growth. Piketty proposes three laws that explain and predict inequality paths over time, but there is no empirical evidence or theoretical foundations for these laws. This project will examine Piketty’s laws and investigate fa ....Inequality and economic growth. This project aims to identify forces driving inequality. Piketty’s influential book, Capital in the 21st Century, stimulated research on inequality to address the increased public concern about inequality and its side-effects such as reduced growth. Piketty proposes three laws that explain and predict inequality paths over time, but there is no empirical evidence or theoretical foundations for these laws. This project will examine Piketty’s laws and investigate factors that shape inequality and its relation to growth. This knowledge should enable Australian governments to reduce inequality and benefit economic growth, thereby reducing disadvantage and building stronger, more resilient communities.Read moreRead less
EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
Restoration Of Diabetes Associated Cognitive Deficits Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$430,998.00
Summary
Diabetes is known to increase the risk of dementia. Although the mechanisms are currently unknown, a recently emerging body of evidence suggest that damaged blood vessels of the brain may be central to onset and progress of cognitive dysfunction. Consistently, the dysfunction of brain blood vessels is often observed in the brain of diabetes subjects. Therefore, this project will investigate whether the amelioration of disrupted brain blood vessels restores the cognitive function in diabetes.
Dementia Associated To Diabetes: Prevention Through The Modulation Of Cerebrovascular Integrity
Funder
National Health and Medical Research Council
Funding Amount
$719,770.00
Summary
Diabetic insulin resistance is reported to induce cognitive decline and dementia. An accumulating body of evidence suggest that compromised integrity of neurovascular unit and following changes in cerebral lipid homeostasis may be centrally involved in the neurodegeneration and cognitive deficits. Therefore, the project aims to prevent the insulin resistance-associated cognitive impairment by modulating the integrity of cerebrovasculature and lipid homeostasis.
Investigating Underlying Mechanisms Linking Type 2 Diabetes With Alzheimer’s Disease Pathology
Funder
National Health and Medical Research Council
Funding Amount
$701,950.00
Summary
With type-2 diabetes representing a major risk factor for neurodegenerative diseases such as Alzheimer's disease, it is important to understand the underlying mechanisms. This project will provide significant insight into how T2D impacts the brain with a focus on how deficiencies in brain inuslin signaling drives neurodegeneration. We will also evaluate novel inuslin like molecules at improving brain insulin siganling and preventing or slowing down the neurodegenerative process.
Sustaining India's economic transformation: challenges, prospects and implications for Australia and the Pacific region. India's emergence from economic stagnation is beginning to have a profound impact on the world economy, including Australia. This project aims to investigate the sources of India's growth and the reforms needed to ensure that growth generates reductions in poverty and ensures equity and political stability.
Regulation Of Neural Progenitor Cell Self-renewal By The RNA-binding Protein ZFP36L1 During Development And Disease
Funder
National Health and Medical Research Council
Funding Amount
$345,401.00
Summary
The timely differentiation of neural stem cells is critical during development, and the unrestrained proliferation of neural stem cells in the adult can lead to deadly brain cancers such as glioma. At present our understanding of the key molecules that regulate neural stem cell behaviour during these processes remains limited. In this proposal we will investigate the molecular determinants underpinning neural stem cell biology, both within the developing brain, and within glioma.
Novel Methods For Promoting Organ Development And Growth
Funder
National Health and Medical Research Council
Funding Amount
$390,203.00
Summary
A revolutionary new therapy for treatment of growth restricted fetuses and premature babies is being developed through the administration of Colony Stimulating Factor (CSF-1). We have evidence that CSF-1 therapy can promote kidneys and lungs to continue development and maturation after birth. This exciting new finding allows for the application of CSF-1 therapy for both the treatment of premature babies and unborn babies with kidney defects.
Government, Institutions and Economic Activity: A Long Term Analysis. Using national and regional data for 30 to 50 countries over multiple centuries, this project will examine the effects of itemised government expenditure and revenue on productivity, investment, saving, labour force participation and research and development. The results are expected to shed light on the macroeconomic effects of different revenue and spending categories (education, transfers, and so on). In addition, the proje ....Government, Institutions and Economic Activity: A Long Term Analysis. Using national and regional data for 30 to 50 countries over multiple centuries, this project will examine the effects of itemised government expenditure and revenue on productivity, investment, saving, labour force participation and research and development. The results are expected to shed light on the macroeconomic effects of different revenue and spending categories (education, transfers, and so on). In addition, the project aims to determine which factors have been responsible for the increase of government size over the past two centuries. The results aim to further reveal which government revenue and expenditure items are most conducive to economic welfare and growth.Read moreRead less