Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100099
Funder
Australian Research Council
Funding Amount
$154,000.00
Summary
Online dietary assessment for research: The Automated Self-Administered 24-Hour Dietary Recall System for Australia (ASA24-Aus). Online dietary assessment for research: the Automated Self-Administered 24-Hour Dietary Recall System for Australia: This project brings together key researchers nationally in the field of nutrition and dietetics to develop a standardised, high quality, online system to assess food intake among adults across a variety of research settings and study designs. The propose ....Online dietary assessment for research: The Automated Self-Administered 24-Hour Dietary Recall System for Australia (ASA24-Aus). Online dietary assessment for research: the Automated Self-Administered 24-Hour Dietary Recall System for Australia: This project brings together key researchers nationally in the field of nutrition and dietetics to develop a standardised, high quality, online system to assess food intake among adults across a variety of research settings and study designs. The proposed infrastructure is an Australian version of the Automated Self-Administered 24-Hour Dietary Recall (ASA24) in collaboration with the United States National Cancer Institute. The infrastructure is internationally renowned and will underpin research that builds the evidence-base for policies and programs in the field of nutrition and dietetics. Read moreRead less
Learned Academies Special Projects - Grant ID: LA170100022
Funder
Australian Research Council
Funding Amount
$118,098.00
Summary
Nourishing Australia: a decadal plan for nutrition science. This project aims to develop a plan to address the complex health and environmental challenges associated with changes in food production and consumption. Since the industrial revolution, our understanding of human diet has lagged behind the rate of change. This project aims to better integrate knowledge across nutrients, foods, meals, diets, and dietary patterns to understand balance rather than single nutrients or commodities. It will ....Nourishing Australia: a decadal plan for nutrition science. This project aims to develop a plan to address the complex health and environmental challenges associated with changes in food production and consumption. Since the industrial revolution, our understanding of human diet has lagged behind the rate of change. This project aims to better integrate knowledge across nutrients, foods, meals, diets, and dietary patterns to understand balance rather than single nutrients or commodities. It will examine the broader context of nutrition from individuals to communities to nations, and globally, and develop a consistent theoretical framework for nutrition that includes both individual biology and the physical, social and biological environment. This will provide broad benefits for social, cultural, economic and health outcomes in the region.Read moreRead less
Modelling policy interventions to protect Australia's food security in the face of environmental sustainability challenges . This project will use an innovative scenario modelling approach to quantify the potential impacts of population growth and emerging climate and environmental challenges on Australia’s future food security. In collaboration with an advisory committee it will specify and prioritise policy solutions in terms of their social and economic credentials.
Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 ....Using Mathematics to Maximize the Efficiency of Shared Infrastructure in Australia's Coal Export Supply Chain. Port Waratah Coal Services operates the world's largest coal export terminal, servicing about 14 coal mining companies in the Hunter Valley, NSW. It is responsible for around $15 billion in annual export income for Australia. The coal supply chain is a complex operation, hampered by bottlenecks in critical shared infrastructure. Such limitations are estimated to cost Australia about $2 billion pa in lost sales. This project will support the design of new infrastructure and processes to ensure an efficient supply chain. The new science resulting will benefit other coal operations in Australia, and potentially other bulk goods supply chains.Read moreRead less
Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and envi ....Improving external validity of stated choice experiments. This project aims to deliver more accurate estimates of choice behaviour by reducing biases due to choice task complexity in surveys as well as design artefacts. Extracting 'true' preferences is challenging, not only due to possible hypothetical bias, but also due to increasingly complex choice tasks and the existence of design artefacts. This project will investigate the latter two in the context of marketing, transport, health, and environmental economics, and proposes new methodologies to extract preferences that more closely reflect true behaviour in real markets.Read moreRead less
Quantifying the role of the Southern Ocean for anthropogenic CO2 uptake. Carbon dioxide (CO2) is the most important greenhouse gas contributing to global warming and climate change. Climate change is likely to have dramatic economic and environmental consequences for Australia. Knowledge and understanding of the complex carbon cycle is fundamental for predicting future atmospheric CO2 levels and managing climate change. The aim of the work proposed here is to quantify and improve our understan ....Quantifying the role of the Southern Ocean for anthropogenic CO2 uptake. Carbon dioxide (CO2) is the most important greenhouse gas contributing to global warming and climate change. Climate change is likely to have dramatic economic and environmental consequences for Australia. Knowledge and understanding of the complex carbon cycle is fundamental for predicting future atmospheric CO2 levels and managing climate change. The aim of the work proposed here is to quantify and improve our understanding of the oceans role in controlling atmospheric CO2 levels. This will be done by combining modeling and observational expertise among UNSW and CSIRO (Marine Research) researchers. Our work will be the first to assess the extent of which the Southern Ocean (and Australian waters) acts as a carbon sink. This will reduce modeling uncertainties in predicting future atmospheric CO2 levels and will also be valuable to the federal government in future international negotiations on climate change.Read moreRead less
Trade policy: maximising benefits for nutrition, food security, human health, and the economy. Depending on how it is done, trade can be good or bad for peoples' health and social well-being. This study will provide evidence to support the development of trade policy which combines economic as well as social and health goals. This will help improve global food security and human health, reduce poverty and support good international relations.
Stable on-demand optimization for workforce and fleet logistics management. This project aims to conceive, develop and deploy innovative methodologies for stable on-demand workforce management and fleet logistics based on advanced decision-support systems. The outcome of this project will provide a new cloud-based real-time Optimisation Software-as-a-Service (OSaaS) platform that allows businesses to improve their productivity while reducing operating costs and their environmental footprint. Thi ....Stable on-demand optimization for workforce and fleet logistics management. This project aims to conceive, develop and deploy innovative methodologies for stable on-demand workforce management and fleet logistics based on advanced decision-support systems. The outcome of this project will provide a new cloud-based real-time Optimisation Software-as-a-Service (OSaaS) platform that allows businesses to improve their productivity while reducing operating costs and their environmental footprint. This is expected to support the manufacturing, retail, delivery and mobile fleets industries.Read moreRead less
Governing harmful commodities: the case of ultra-processed foods. This project aims to generate new knowledge on how to influence public policy in order to reduce the supply and consumption of a health-harming commodity, ultra-processed foods. Using governance theory and qualitative techniques the project intends to identify the actors who are influential in the three key policy areas of trade, taxation and marketing and who affect the consumption of these foods in Australia, Thailand and Fiji. ....Governing harmful commodities: the case of ultra-processed foods. This project aims to generate new knowledge on how to influence public policy in order to reduce the supply and consumption of a health-harming commodity, ultra-processed foods. Using governance theory and qualitative techniques the project intends to identify the actors who are influential in the three key policy areas of trade, taxation and marketing and who affect the consumption of these foods in Australia, Thailand and Fiji. Expected outcomes include strategies for pursuing these different actors’ interests and evidence that can help institutions to promote better policies. Intended benefits include better nutrition outcomes in Australia, Thailand and Fiji.Read moreRead less