Evolution And Function Of A Novel Lateral Flagellar Locus, Flag-2, In Pathogenic Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$465,158.00
Summary
This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified a novel genetic region that allows E. coli to survive and persist in the intestine. Similar genes are also present in closely related organisms. This project will help us to undestand how new diseases evolve and emerge and may lead to the development of new vaccines to protect against infant diarrhoea.
Macroecology of reptiles and frogs over latitudinal and temporal gradients. This project aims to address major macroecological concepts in reptile and frog communities through time, focusing on environmental and climatic gradients in species diversity and body-size variation. This project expects to generate a unique macroecological dataset by integrating data from Quaternary fossil sites spanning a 3000km latitudinal gradient with current ecological data. Expected outcomes include the first com ....Macroecology of reptiles and frogs over latitudinal and temporal gradients. This project aims to address major macroecological concepts in reptile and frog communities through time, focusing on environmental and climatic gradients in species diversity and body-size variation. This project expects to generate a unique macroecological dataset by integrating data from Quaternary fossil sites spanning a 3000km latitudinal gradient with current ecological data. Expected outcomes include the first comprehensive ecological assessment of Australian reptile and frog communities through Pleistocene climate oscillations, with predictions into the future. This research will benefit Australian society by providing evidence-based knowledge of faunal community composition through time in association with changing climates.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100121
Funder
Australian Research Council
Funding Amount
$384,671.00
Summary
Genomic library infrastructure for ancient environmental samples. This project aims to enable automated genome recovery from diverse environmental samples, without contamination risk. For more than 100 years, environmental scientists have studied diverse organism / environment interactions using a variety of conceptual and technical tools. Recently, studies of ancient and historical DNA have come to complement these tools and to occupy a significant place in environmental studies conducted over ....Genomic library infrastructure for ancient environmental samples. This project aims to enable automated genome recovery from diverse environmental samples, without contamination risk. For more than 100 years, environmental scientists have studied diverse organism / environment interactions using a variety of conceptual and technical tools. Recently, studies of ancient and historical DNA have come to complement these tools and to occupy a significant place in environmental studies conducted over serial time. The project’s addition to the existing dual Ancient DNA complex facility at Griffith University will comprise two liquid handling workstations, each being housed in separate, self-contained, ancient DNA laboratories. The new facility will enable many researchers to have unprecedented access to an ancient DNA facility and a high level of technical support.Read moreRead less
An elemental hypothesis for sub-tropical refugia in reef corals. This project aims to discover the underlying traits that permit Australian reef corals to live near the edges of their ranges in relatively cool water. As ocean temperatures warm, novel communities are expected to develop in high latitude ecosystems, which might become important as thermal refugia for low latitude coral reefs. The project aims to test the role of elemental composition (carbon, nitrogen and phosphorus) in coral host ....An elemental hypothesis for sub-tropical refugia in reef corals. This project aims to discover the underlying traits that permit Australian reef corals to live near the edges of their ranges in relatively cool water. As ocean temperatures warm, novel communities are expected to develop in high latitude ecosystems, which might become important as thermal refugia for low latitude coral reefs. The project aims to test the role of elemental composition (carbon, nitrogen and phosphorus) in coral host and symbiont response to changing water temperature along a latitudinal gradient. The intended outcome of the project is to provide knowledge to support predictions of likely species migrations from tropical to subtropical waters, enabling managers to anticipate the future response of coral communities to seawater warming.Read moreRead less
From prediction to adaptation: responding to rapid ecosystem shifts under climate change. Nobody knows exactly how climate change will affect the ecosystems on which we depend for our own existence, though negative impacts are widely predicted. This project integrates mathematical, economic and ecological approaches to learn about the most effective way to spend limited funds for sustaining ecosystems threatened by climate change.
Outfoxing the fox: new cost-effective ways to protect threatened species. This project aims to address the damage caused by invasive foxes by applying new methods of protection for threatened species. This project expects to generate new knowledge in the areas of conservation biology and invasive species management by comparing the effectiveness of fox control strategies for improving the population viability of declining freshwater turtles. Expected outcomes of this project include a community- ....Outfoxing the fox: new cost-effective ways to protect threatened species. This project aims to address the damage caused by invasive foxes by applying new methods of protection for threatened species. This project expects to generate new knowledge in the areas of conservation biology and invasive species management by comparing the effectiveness of fox control strategies for improving the population viability of declining freshwater turtles. Expected outcomes of this project include a community-based conservation model that prevents turtle extinctions in south-eastern Australia at considerable cost savings. Significant benefits include improved management of the impacts of invasive species, and restoration of ecosystem services provided by the scavenging role of freshwater turtles for maintaining water quality.Read moreRead less
Diversity maintenance in patchy environments. This project aims to advance understanding of species coexistence and diversity maintenance in complex natural environments. Though diversity varies across patchy natural and human-created environments, the mechanistic drivers of these patterns remain poorly understood. This knowledge gap limits our ability to predict and manage responses of natural communities to environmental changes. Using data from threatened Western Australian wildflower communi ....Diversity maintenance in patchy environments. This project aims to advance understanding of species coexistence and diversity maintenance in complex natural environments. Though diversity varies across patchy natural and human-created environments, the mechanistic drivers of these patterns remain poorly understood. This knowledge gap limits our ability to predict and manage responses of natural communities to environmental changes. Using data from threatened Western Australian wildflower communities and novel ecological models of species coexistence, the project aims to deliver a mechanistic understanding of biological diversity, and provide fundamental knowledge needed to improve ecosystem management and restoration outcomes across Australia and globally.Read moreRead less
Bacterial and host drivers of chlamydial blindness in koalas. Chlamydial infection of the eyes is a significant cause of disease and death in koalas, contributing to the ongoing decline of this native species. Little is known about what influences the outcome of these infections, challenging efforts to manage and control koala chlamydial blindness. This project aims to evaluate whether differences in the infecting Chlamydia pecorum strains or the koala immune response, are associated with the ou ....Bacterial and host drivers of chlamydial blindness in koalas. Chlamydial infection of the eyes is a significant cause of disease and death in koalas, contributing to the ongoing decline of this native species. Little is known about what influences the outcome of these infections, challenging efforts to manage and control koala chlamydial blindness. This project aims to evaluate whether differences in the infecting Chlamydia pecorum strains or the koala immune response, are associated with the outcome of chlamydial ocular infection. In addition to helping us to understand and prevent blindness in koalas, this project should significantly expand our knowledge of the koala immune system and generate an array of koala immunological assays, outcomes that may benefit all koala conservation efforts.Read moreRead less
Unravelling reef fish vision through gene-editing and behavioural ecology. This project aims to enhance understanding of visual neuroscience, genetic control of vision and environmental ecology on The Great Barrier Reef (GBR). Using the anemonefish as a model, together with new genetic, photographic and behavioural approaches, the project aims to reveal novel aspects of colour vision on the reef. Outcomes beyond multiple scientific disciplines include enhanced international collaboration and bui ....Unravelling reef fish vision through gene-editing and behavioural ecology. This project aims to enhance understanding of visual neuroscience, genetic control of vision and environmental ecology on The Great Barrier Reef (GBR). Using the anemonefish as a model, together with new genetic, photographic and behavioural approaches, the project aims to reveal novel aspects of colour vision on the reef. Outcomes beyond multiple scientific disciplines include enhanced international collaboration and building capacity for improved reef guardianship. The benefits are scientific discovery in multiple areas, providing greater community understanding of complex science and a desire to preserve the GBR for future generations.Read moreRead less
Development of cryopreservation for high value provenance collections of recalcitrant plant species used in post-mining restoration. This project will develop new and innovative ways to store highly valued native plant germplasm at ultra cold temperatures (-196 °C, in liquid nitrogen) as a means to ensure that elite genotypes used in minesite restoration and critically endangered species are not lost forever to extinction. This project will be the first of its type in Australia utilising a multi ....Development of cryopreservation for high value provenance collections of recalcitrant plant species used in post-mining restoration. This project will develop new and innovative ways to store highly valued native plant germplasm at ultra cold temperatures (-196 °C, in liquid nitrogen) as a means to ensure that elite genotypes used in minesite restoration and critically endangered species are not lost forever to extinction. This project will be the first of its type in Australia utilising a multidisciplinary approach to answer key storage questions and will provide significant national benefits to conservation programs and landcare groups, providing these with additional resources to ensure the long-term survival of native plant germplasm collections. Read moreRead less