Evolution And Function Of A Novel Lateral Flagellar Locus, Flag-2, In Pathogenic Escherichia Coli
Funder
National Health and Medical Research Council
Funding Amount
$465,158.00
Summary
This project will study how the bacteria that cause infant diarrhoea colonize the intestine and induce disease. We have identified a novel genetic region that allows E. coli to survive and persist in the intestine. Similar genes are also present in closely related organisms. This project will help us to undestand how new diseases evolve and emerge and may lead to the development of new vaccines to protect against infant diarrhoea.
Integrating evolution and plasticity into predictions of population persistence in a changing climate: adaptation or extinction? To effectively manage biodiversity at a time of rapid environmental change, Australia needs accurate predictions of how human alterations to climate and habitat will affect species. This project integrates evolution and spatial ecology to develop new tools for predicting and understanding how species will respond to environmental change.
The basis of oyster resilience to global environmental change. This project aims to investigate the impact of global environmental change on the survival of Australia’s oyster industry, by combining the science of genetics, physiology and ecology to identify already resilient oysters. Through the first complete understanding of resilience in oysters, including the trade-offs they have made in other fitness traits, the project develops new capacities to 'climate and future-proof' our natural oyst ....The basis of oyster resilience to global environmental change. This project aims to investigate the impact of global environmental change on the survival of Australia’s oyster industry, by combining the science of genetics, physiology and ecology to identify already resilient oysters. Through the first complete understanding of resilience in oysters, including the trade-offs they have made in other fitness traits, the project develops new capacities to 'climate and future-proof' our natural oyster populations and the Australian oyster industry, to enable the restoration of degraded oyster habitats. This project will ensure the future of an iconic and economically important national industry and food source and contribute to preserving the critical cultural links of Indigenous Australians with their lands.Read moreRead less
The reliability of corporate reporting of greenhouse gas estimates: Determinants, consequences, training for accountants and policy Initiatives. Fundamental to the successful re-allocation of resources to address climate change is that greenhouse gas estimates reported by firms are reliable. The first outcome from this research is the development of tools to assist and train the Australian accountancy profession in the estimation of reliable emissions. The second outcome is identification of fac ....The reliability of corporate reporting of greenhouse gas estimates: Determinants, consequences, training for accountants and policy Initiatives. Fundamental to the successful re-allocation of resources to address climate change is that greenhouse gas estimates reported by firms are reliable. The first outcome from this research is the development of tools to assist and train the Australian accountancy profession in the estimation of reliable emissions. The second outcome is identification of factors associated with the inaccuracy and bias of greenhouse gas emissions reported by companies and the consequences of the inaccuracies for the share market's valuation of emission liabilities. These research findings will identify issues that need to be addressed by regulators to ensure that the greenhouse gas estimates reported by companies are reliable.Read moreRead less
Peripheral isolates as hotbeds of adaptive diversity. This project uses cutting edge molecular technology and spatial analyses to predict the location of diversity relevant to managing the impact of climate change. Knowledge generated in this project will open the door to the informed use of genetic translocation in efforts to kerb expected biodiversity losses.
Detecting sex differences in natural selection. This project aims to develop new genomic approaches for understanding how genetic mutations can differentially affect reproductive success in males and females. Applying novel tests, this project aims to uncover previously hidden genetic conflicts between the sexes. This will provide significant benefits, such as new tools that will be broadly applicable to the wider research community, and help to answer key questions in genetics and evolutionary ....Detecting sex differences in natural selection. This project aims to develop new genomic approaches for understanding how genetic mutations can differentially affect reproductive success in males and females. Applying novel tests, this project aims to uncover previously hidden genetic conflicts between the sexes. This will provide significant benefits, such as new tools that will be broadly applicable to the wider research community, and help to answer key questions in genetics and evolutionary biology in the current genomic era.Read moreRead less
Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of mul ....Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of multi-disciplinary approaches, ranging from future climate models, historical satellite data to in-field experimentation to fill fundamental knowledge gaps in our understanding of coral bleaching recovery and delivery a variety of management and stakeholder relevant outputs.Read moreRead less
Diversity maintenance in patchy environments. This project aims to advance understanding of species coexistence and diversity maintenance in complex natural environments. Though diversity varies across patchy natural and human-created environments, the mechanistic drivers of these patterns remain poorly understood. This knowledge gap limits our ability to predict and manage responses of natural communities to environmental changes. Using data from threatened Western Australian wildflower communi ....Diversity maintenance in patchy environments. This project aims to advance understanding of species coexistence and diversity maintenance in complex natural environments. Though diversity varies across patchy natural and human-created environments, the mechanistic drivers of these patterns remain poorly understood. This knowledge gap limits our ability to predict and manage responses of natural communities to environmental changes. Using data from threatened Western Australian wildflower communities and novel ecological models of species coexistence, the project aims to deliver a mechanistic understanding of biological diversity, and provide fundamental knowledge needed to improve ecosystem management and restoration outcomes across Australia and globally.Read moreRead less
Sea-level rise and everyday lives in small island states. This project aims to advance understanding of the impacts of sea-level rise and associated policy responses on the everyday lives of island communities. Focusing on village relocation in Fiji and fortification and land reclamation in the Maldives, the project will analyse people's changing everyday experiences and practices. The project seeks to enable international and interdisciplinary collaborations, and to produce new knowledge on the ....Sea-level rise and everyday lives in small island states. This project aims to advance understanding of the impacts of sea-level rise and associated policy responses on the everyday lives of island communities. Focusing on village relocation in Fiji and fortification and land reclamation in the Maldives, the project will analyse people's changing everyday experiences and practices. The project seeks to enable international and interdisciplinary collaborations, and to produce new knowledge on the opportunities and challenges of diverse policy responses to sea-level rise. The project’s findings will be beneficial for countries facing the threat of sea-level rise, as well as national governments and international agencies that support and fund climate adaptation.Read moreRead less
ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ....ARC Australia-New Zealand Research Network for Vegetation Function. Plant species vary widely in quantitative functional traits, and in their relations to climate, soils and geography. Global generalizations are emerging. Vegetation Function network will reach from plant function into genomics and crop breeding, into palaeoecology and vegetation history, into landscape management for carbon, water and salinity outcomes, into forecasting future ecosystems under global change, and into phylogeny, ecoinformatics and evolutionary theory. Across this span, working groups will target nine identified opportunities for breakthrough research. Each research target needs input from two or more disciplines. Together, the nine targets link across disciplines, as a network that spans from genomic to planetary scales.Read moreRead less