An explainability oriented approach to manage dependent supply chain risks. This project aims to help supply chain companies model the impact on their operations by capturing the uncertainties impacting their upstream suppliers. In the current uncertain business environment, the project's outcome will benefit service-based industries to have an enhanced understanding of their operating environment and take decisions accordingly to avoid failures. This will significantly increase the productivity ....An explainability oriented approach to manage dependent supply chain risks. This project aims to help supply chain companies model the impact on their operations by capturing the uncertainties impacting their upstream suppliers. In the current uncertain business environment, the project's outcome will benefit service-based industries to have an enhanced understanding of their operating environment and take decisions accordingly to avoid failures. This will significantly increase the productivity of Australian service-based industries across different domains. The expected outcome is that it generates new knowledge by which risk managers of a focal company can conjointly consider risk identification/assessment with risk management analysis to develop explainable strategies for managing uncertainties. Read moreRead less
Sympathetic Control Of Cutaneous Blood Flow And Blood Pressure In Human Spinal Cord Injury
Funder
National Health and Medical Research Council
Funding Amount
$242,002.00
Summary
While spinal cord injury can cause devastating changes in the nervous system paralysis and loss of sensation relatively little is known about changes to the sympathetic nervous system. The sympathetic nervous system is intimately involved in the ongoing control of blood pressure, blood flow and temperature control. Loss of sympathetic control can occur following spinal cord injury. Interruption of descending pathways can result in partial or complete loss of sympathetic outflow from the thoracol ....While spinal cord injury can cause devastating changes in the nervous system paralysis and loss of sensation relatively little is known about changes to the sympathetic nervous system. The sympathetic nervous system is intimately involved in the ongoing control of blood pressure, blood flow and temperature control. Loss of sympathetic control can occur following spinal cord injury. Interruption of descending pathways can result in partial or complete loss of sympathetic outflow from the thoracolumbar segments. Complete decentralization can result in autonomic dysreflexia (autonomic hyperreflexia), in which sensory stimuli originating below the lesion evoke a reflex increase in sympathetic drive to the blood vessels, causing them to constrict. Because of this, blood pressure may rise suddenly and remain at such high levels that stroke and (occassionally) cardiac arrest may occur. This phenomenon, autonomic dysreflexia, is considered a medical emergency. The typical subjective signs of autonomic dysreflexia include a throbbing headache, tingling in the head or nasal congestion; sweating and flushing above the lesion are clinical signs that prompt medical staff to measure blood pressure and to locate the source of sensory irritation (usually a distended bladder or impacted colon, sometimes a pressure sore or ingrown toenail). Commonly, however, subclinical episodes go undetected, and this phenomenon of silent dysreflexia is of increasing concern. This project will develop means of assessing the integrity and state of the sympathetic nervous system below a lesion in patients with spinal cord injury and characterize the firing properties of reflexly activated sympathetic neurones.Read moreRead less
Integrating land use, market equilibrium, and transport for city planning. This project is significant because it offers a comprehensive travel demand modelling platform that provides realistic, robust, and self-consistent metrics for transport infrastructure planning addressing contemporary changes in the transport system. The expected outcomes of the platform are incorporating recent advances in activity-based methods for travel demand modelling, developing a dynamic and integrated system for ....Integrating land use, market equilibrium, and transport for city planning. This project is significant because it offers a comprehensive travel demand modelling platform that provides realistic, robust, and self-consistent metrics for transport infrastructure planning addressing contemporary changes in the transport system. The expected outcomes of the platform are incorporating recent advances in activity-based methods for travel demand modelling, developing a dynamic and integrated system for modelling short- and long-term household decisions, and creating a systematic calibration mechanism to handle the large-scale model. The benefits of this platform to the Australian transport industry and authorities will be demonstrated in use cases to design and optimise pricing for a multiplayer transport network.Read moreRead less
Central Aortic Blood Pressure In Children: Establishing A Gold Standard Non-invasive Assessment Of Cardiovascular Risk
Funder
National Health and Medical Research Council
Funding Amount
$694,342.00
Summary
The best way of assessing early risk of cardiovascular disease involves measuring blood pressure near the heart (central pressure), but existing devices used in adults for this purpose are inaccurate in children. We will develop a children-specific method and apply it to study early cardiovascular risk in a comprehensive health study of 2000 children Australia-wide. We will also investigate why children with congenital heart disease frequently develop ‘older-adult’ heart disease at a young age.
Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribut ....Technological innovation and change in supply chain integration. In examining emerging technology that can transform the performance of Australian industry we address the following priority goals: better understanding the processes that will advance knowledge and facilitate the development of technological innovations; the potential application of Radio Frequency Identification (RFID) technologies across an entire supply chain; and the improved management of information in the storage, distribution, and delivery of products (smart information use). Improvement in the operational efficiency and performance of the supply chain will increase national wealth while minimising environmental impacts on the environment, for example, through the better utilisation of heavy freight carriers.Read moreRead less
Drug-induced Immune Thrombocytopenia: Understanding The Disease Mechanisms Is The Key To Better Treatment
Funder
National Health and Medical Research Council
Funding Amount
$509,550.00
Summary
Many very commonly used medications cause an allergic reaction in a small number of patients that receive them. The allergic reaction results in platelets being destroyed and puts the patients at risk of bleeding. The patient recovers slowly if the drug is stopped but there is no other treatment and no way to reverse the effect quickly if the patient starts to bleed. This project will try to understand the mechanism of the condition and test a potential treatment.
Competitive supplier bidding in supply chains. This project will use mathematical modelling to contribute to better management practice in dealing with procurement. With the increasing use of auctions and sophisticated bidding procedures it is essential to improve our understanding of this important area.
Australian Centre For Research Excellence In Aboriginal Sexual Health And Blood Borne Viruses
Funder
National Health and Medical Research Council
Funding Amount
$2,496,848.00
Summary
Despite efforts to improve sexual health and blood borne virus outcomes for Aboriginal people over the last twenty years, this area lacks national coordination, has critical research gaps and requires a boost of research capacity to address the burden of diseases. This CRE will address research gaps, using novel, multidisciplinary methods and using unique research translation methods to ensure policy and practice benefits from the CRE outcomes.
All-Solid-state Sodium-ion Batteries for Renewable Energy Industry. Sodium-ion batteries have been widely recognised as scalable and sustainable system for renewable energy storage and conversion owing to abundant resource of sodium and low cost. However, the electrochemical performance and safety of this technology must be improved for practical deployment. This project aims to rationally design and synthesise solid-state polymer electrolytes with high sodium ion conductivity and high sodium io ....All-Solid-state Sodium-ion Batteries for Renewable Energy Industry. Sodium-ion batteries have been widely recognised as scalable and sustainable system for renewable energy storage and conversion owing to abundant resource of sodium and low cost. However, the electrochemical performance and safety of this technology must be improved for practical deployment. This project aims to rationally design and synthesise solid-state polymer electrolytes with high sodium ion conductivity and high sodium ion transfer number. The expected outcome of the project is to manufacture all-solid-state sodium-ion batteries for renewable energy industry in Australia. The project will support the transition of energy supply to renewables, and therefore attain a secure and reliable zero-carbon emission energy future. Read moreRead less