Short silk nanofibre based 3D scaffolds with enhanced biomimicry. This project aims to understand the behaviour of haematopoietic stem cells (HSC) in novel 3D scaffolds based on short silk nanofibres. This will lead to highly functional 3D scaffolding materials that support efficient HSC renewal in vitro. This project aims to overcome the key problem with existing in vitro systems, which lack the morphological and biochemical complexities of native HSC-niche. Since haematopoietic stem cells are ....Short silk nanofibre based 3D scaffolds with enhanced biomimicry. This project aims to understand the behaviour of haematopoietic stem cells (HSC) in novel 3D scaffolds based on short silk nanofibres. This will lead to highly functional 3D scaffolding materials that support efficient HSC renewal in vitro. This project aims to overcome the key problem with existing in vitro systems, which lack the morphological and biochemical complexities of native HSC-niche. Since haematopoietic stem cells are the precursors to all blood cells, this project has the potential of engineering a high yield artificial ‘blood factory’, which will help save the lives of many thousands of people who rely on bone marrow transplants to treat life-threatening illness such as leukaemia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100129
Funder
Australian Research Council
Funding Amount
$425,200.00
Summary
Atomic layer nanofabrication system for multi-functional applications. This project aims to establish a multifunctional atomic layer nanofabrication facility in Sydney with the capacity to provide services nation-wide. The facility has powerful capabilities to produce mono-atom thin films, nanosize powders and two-dimensional nanostructures of a variety of materials, including elemental metals, metal oxides, metal nitrides, metal sulfides, metal-metal compounds, and polymers. This will significa ....Atomic layer nanofabrication system for multi-functional applications. This project aims to establish a multifunctional atomic layer nanofabrication facility in Sydney with the capacity to provide services nation-wide. The facility has powerful capabilities to produce mono-atom thin films, nanosize powders and two-dimensional nanostructures of a variety of materials, including elemental metals, metal oxides, metal nitrides, metal sulfides, metal-metal compounds, and polymers. This will significantly enhance Australian research and industrial activities in the areas of renewable energy production and storage, microelectronics, chemical and bio-sensors, protective coatings, flexible electronic devices, and catalysis.Read moreRead less