Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Predictive Analytics and Real-time Traffic Control for Urban Corridors. This project aims to develop predictive data analytics and real-time traffic control and safety models for multimodal management of urban corridors, serving two salient objectives: (1) optimising person-throughput of multimodal traffic; while (2) minimising safety risks for all modes. The outcome will be an automated, sensor-based platform to monitor traffic flows from all modes and make proactive and coordinated control dec ....Predictive Analytics and Real-time Traffic Control for Urban Corridors. This project aims to develop predictive data analytics and real-time traffic control and safety models for multimodal management of urban corridors, serving two salient objectives: (1) optimising person-throughput of multimodal traffic; while (2) minimising safety risks for all modes. The outcome will be an automated, sensor-based platform to monitor traffic flows from all modes and make proactive and coordinated control decisions in real-time. The expected benefits are profound; the developed algorithms and platform will significantly reduce traffic congestion, travel delays and safety risks for all modes of transport, especially for vulnerable road users (e.g. pedestrians and cyclists).Read moreRead less
iMATCH: Independent mobility, active travel and children's health. Policy interventions are used across Australia to improve children's independent mobility, to increase children's physical activity levels and social interaction, and to generate more sustainable travel behaviour, particularly for the journey to school. iMATCH provides a holistic and inter-disciplinary evaluation of policy interventions than is undertaken for most evaluations of school travel and children's travel behaviour polic ....iMATCH: Independent mobility, active travel and children's health. Policy interventions are used across Australia to improve children's independent mobility, to increase children's physical activity levels and social interaction, and to generate more sustainable travel behaviour, particularly for the journey to school. iMATCH provides a holistic and inter-disciplinary evaluation of policy interventions than is undertaken for most evaluations of school travel and children's travel behaviour policies and programs. By controlling for the influence of the built and social environment, the project will provide the necessary support to justify these policy interventions and to identify key improvements for their delivery, supporting more sustainable and healthy lifestyles for Australia's children.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100118
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
The National Cycling Data and Analysis Platform (NCDAP) . A National Cycling Data and Analytics Platform to collect, integrate and communicate new and historic data on cycling infrastructure, attitudes, and behaviours. This project will address the significant issue of data fragmentation, pilot a national cycling survey, and develop a cycling toolkit to allow exploring and testing various cycling infrastructure scenarios. The platform will provide an open access e-Infrastructure to enable tracki ....The National Cycling Data and Analysis Platform (NCDAP) . A National Cycling Data and Analytics Platform to collect, integrate and communicate new and historic data on cycling infrastructure, attitudes, and behaviours. This project will address the significant issue of data fragmentation, pilot a national cycling survey, and develop a cycling toolkit to allow exploring and testing various cycling infrastructure scenarios. The platform will provide an open access e-Infrastructure to enable tracking social and cultural changes that influence transport choices, create effective behaviour change programs and prioritise cycling infrastructure investment. This project will contribute to healthier lifestyles, reduced traffic congestion and emissions and energy efficiency of Australia’s transport sector.Read moreRead less
The Effects of Nano and Ultrafine Particles from Traffic Emissions on Children's Health. The socio-economic benefits to Australia will include (i) quantitative knowledge of the exposure to nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates and (ii) a breakthrough in the scientific understanding of the specific particle properties, which have impacts on health effects. The ultimate economic benefit will be improved urban design to lower, in pa ....The Effects of Nano and Ultrafine Particles from Traffic Emissions on Children's Health. The socio-economic benefits to Australia will include (i) quantitative knowledge of the exposure to nano and ultrafine particles, pollutants in the centre of current scientific, medical and policy debates and (ii) a breakthrough in the scientific understanding of the specific particle properties, which have impacts on health effects. The ultimate economic benefit will be improved urban design to lower, in particular, children's exposure to ultrafine particles, thus reducing life long impacts, health care cost and productivity losses. The research will also place Australia at the forefront of international progress towards better methods for achieving environmental and public health sustainability.Read moreRead less
Understanding impact of autonomous vehicles on behaviour and interactions. Understanding impact of autonomous vehicles on behaviour and interactions. This project aims to explore three human factor issues critical to the successful deployment of automated vehicles: factors influencing driver choice of automated vehicle control; interactions between automated and manually controlled vehicles; and driver detection, recognition, and reaction to automated vehicle system failures. Automated vehicles ....Understanding impact of autonomous vehicles on behaviour and interactions. Understanding impact of autonomous vehicles on behaviour and interactions. This project aims to explore three human factor issues critical to the successful deployment of automated vehicles: factors influencing driver choice of automated vehicle control; interactions between automated and manually controlled vehicles; and driver detection, recognition, and reaction to automated vehicle system failures. Automated vehicles are predicted to be transformative, but their ultimate success and expected societal benefits will depend on drivers’ trust in them and on how people choose to use and interact with them. Insights from this research should prepare our society for more automated vehicles on the roadways.Read moreRead less
Onset Theory: Pushing the design envelope for textile composite structures. This study aims to exploit an innovative physics-based approach to predict the strength of textile composites. This is particularly important in areas such as aircraft design, where drastic weight savings are needed to allow designers to remain competitive in a low-carbon future. Improved theory and design tools will remove conservatism and account for a large part of these weight savings. The new approach is the first t ....Onset Theory: Pushing the design envelope for textile composite structures. This study aims to exploit an innovative physics-based approach to predict the strength of textile composites. This is particularly important in areas such as aircraft design, where drastic weight savings are needed to allow designers to remain competitive in a low-carbon future. Improved theory and design tools will remove conservatism and account for a large part of these weight savings. The new approach is the first to be consistent at all length scales — from atoms to aeroplanes — ensuring relevance for new and evolving composite material systems. A novel understanding of crack initiation in textile laminates is intended to reduce design and certification effort for new aircraft and help to design more efficient airframes at a lower cost.Read moreRead less
Advanced Combustion Modelling for Scramjets and Rotating Detonation Engines. This project will develop new fundamental knowledge and engineering models underpinning air-breathing high speed propulsion engines employing complex hydrocarbon fuels. Extensive data and new physical understanding will be garnered through analysis of direct numerical simulations of supersonic reacting mixing layers including impinging shock waves. That data will be employed to isolate, test and develop computationally ....Advanced Combustion Modelling for Scramjets and Rotating Detonation Engines. This project will develop new fundamental knowledge and engineering models underpinning air-breathing high speed propulsion engines employing complex hydrocarbon fuels. Extensive data and new physical understanding will be garnered through analysis of direct numerical simulations of supersonic reacting mixing layers including impinging shock waves. That data will be employed to isolate, test and develop computationally efficient engineering models that are accurate and efficient for high speed combustion in rotating detonation engines and scramjets. Expected outcomes are knowledge and tools needed to develop practical and effective supersonic propulsion engines for access to space, defence and high speed point-to-point flight.
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The Australian naturalistic driving study: innovation in road safety research and policy. A revolutionary new approach, the naturalistic driving study, will investigate what people actually do when they drive, in normal and safety-critical situations. It will provide Australia with answers to some intractable, high priority, road safety problems that cannot be answered using current methods, thereby saving hundreds of lives.