Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Transient Receptor Potential Channels (TRPs) As Transducers And Targets In Primary Visceral Afferents
Funder
National Health and Medical Research Council
Funding Amount
$669,130.00
Summary
Transient receptor potential, or TRP channels, are involved in generating many of the sensations we perceive, such as heat, cold, touch and pain. Some TRP channels are specialized to signal pain from visceral organs, which we must investigate if we are to find treatments for visceral pain, which are currently lacking.
Modelling The Biology And Transmission Of Influenza Virus - Learning From 1918-19 And Other Outbreaks
Funder
National Health and Medical Research Council
Funding Amount
$114,222.00
Summary
In preparing for a future pandemic of influenza, it is important to learn as much as possible from what happened in the past, particularly from the devastating pandemic of 1918-19. This project will collate detailed information about the spread of influenza in past outbreaks and create a publicly accessible data-base. Mathematical methods will be used to analyse historic and contemporary data, so as to provide better understanding of the spread of influenza, and of the likely effects of social a ....In preparing for a future pandemic of influenza, it is important to learn as much as possible from what happened in the past, particularly from the devastating pandemic of 1918-19. This project will collate detailed information about the spread of influenza in past outbreaks and create a publicly accessible data-base. Mathematical methods will be used to analyse historic and contemporary data, so as to provide better understanding of the spread of influenza, and of the likely effects of social and medical measures for its control. An important theme of the project is to consolidate our knowledge about how past exposure to non-pandemic influenza could provide short-lived protection against any new pandemic, and to explore the implications of this for prevention today. Another theme is to explore the severity of influenza during pandemics, and to identify social and medical factors that might reduce the dose of virus transmitted, or otherwise reduce the severity of infection. The insights from the modeling will also help to identify gaps in knowledge and understanding about the basic biology of influenza, stimulate new research to fill those gaps, and thus offer the prospect of more effective vaccines and treatments for the future control of influenza.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hard ....Reducing Blackout Risk through Live Modelling and Monitoring. This project aims to reduce the risk of blackouts through the development of on-line systems for modelling and monitoring of loads and power system controllers. This project is a collaboration with Transgrid, Powerlink, Vencorp and ElectraNetSA, four Transmission companies renowned for innovation in the area of system stability. The project proposes to develop innovative algorithms and to implement these algorithms using advanced hardware, software and communication systems to dynamically generate decision tools for safe and efficient power system operating conditions. These systems will also generate alarms if any risky operational situations arise.Read moreRead less
Performance analysis of the Unified Power Flow Controller based on multi-bridge converter. The objective of this research is to conceive a new configuration of UPFC without series injection transformers, based on two-level full-bridge modules. The conceived system can be utilized for the power systems to control the power flow through the transmission line.
The benefit is in reducing restrictions on electricity transfer links.
The project will develop a laboratory version of the novel UPFC de ....Performance analysis of the Unified Power Flow Controller based on multi-bridge converter. The objective of this research is to conceive a new configuration of UPFC without series injection transformers, based on two-level full-bridge modules. The conceived system can be utilized for the power systems to control the power flow through the transmission line.
The benefit is in reducing restrictions on electricity transfer links.
The project will develop a laboratory version of the novel UPFC demonstrating the hardware and control requirements for this form of UPFC which could reduce the costs of this corrective solution up to 30% below existing solutions.
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EMERGENCY CONTROL FOR POWER SYSTEM SEPARATION. In 2003 we saw major blackouts of power systems for US/Canada, Italy and London leading to billions of dollars of lost production and major impacts on many peoples lives. One aspect contributing to some of these is the control of system dynamic response and the targeted use of emergency controls such as load and generator shedding. This project is contributing to the development of an integrated control response such that appropriate levels of emerg ....EMERGENCY CONTROL FOR POWER SYSTEM SEPARATION. In 2003 we saw major blackouts of power systems for US/Canada, Italy and London leading to billions of dollars of lost production and major impacts on many peoples lives. One aspect contributing to some of these is the control of system dynamic response and the targeted use of emergency controls such as load and generator shedding. This project is contributing to the development of an integrated control response such that appropriate levels of emergency controls are determined and the probability of cascading blackouts reduced through automated systems. Read moreRead less
Advanced Planning Tools for the Prevention of System-wide Blackouts of Large Power Systems. In 2003 there had been major power blackouts in US/Canada, Italy and in Scandinavia leading to billions of dollars of lost production and had raised concern about national security. Prevention of blackout should be one of the highest priorities of the electricity industry. National security for any critical infrastructure of any country is more vulnerable for a prolonged blackout. This project will provid ....Advanced Planning Tools for the Prevention of System-wide Blackouts of Large Power Systems. In 2003 there had been major power blackouts in US/Canada, Italy and in Scandinavia leading to billions of dollars of lost production and had raised concern about national security. Prevention of blackout should be one of the highest priorities of the electricity industry. National security for any critical infrastructure of any country is more vulnerable for a prolonged blackout. This project will provide comprehensive planning tools to prevent blackouts in the Australian National Electricity grid. Any benefit to electricity industry will finally result in further benefits to the national economy and security as a whole.
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