Many heart diseases are associated with impairment of energetics of the heart. Improving the heart's energetics can lead to improved survival and long-term outcomes. Perhexiline is a heart medication that works by improving the way the heart uses energy. Although effective, it is associated with long-term toxicities. Better understanding of this medication may lead to less adverse effects and also provide a basis for further investigation of drug development in the future.
Industrial Transformation Training Centres - Grant ID: IC220100028
Funder
Australian Research Council
Funding Amount
$4,969,602.00
Summary
ARC Training Centre for Innovative Composites for the Future of Sustainable Mining Equipment. The Centre aims to train industry-focused researchers in advanced manufacturing of new-generation mining equipment and sustainable mining technology, through close collaborations among key universities and mining and manufacturing companies. The Centre will cultivate a team of world-class academic researchers and industry leaders to deliver an innovative program on research of innovative composites coup ....ARC Training Centre for Innovative Composites for the Future of Sustainable Mining Equipment. The Centre aims to train industry-focused researchers in advanced manufacturing of new-generation mining equipment and sustainable mining technology, through close collaborations among key universities and mining and manufacturing companies. The Centre will cultivate a team of world-class academic researchers and industry leaders to deliver an innovative program on research of innovative composites coupled with work-integrated learning, to not only produce a workforce that meets future skills demand but also develop sustainable and cost-effective mining equipment and high-efficiency mining technologies, benefiting the nation's manufacturing and mining sectors and significantly enhancing the competitiveness of the Australian mining industry.Read moreRead less
The Australasian Stress Map. The contemporary crustal stress field of Australasia is both more complex and more poorly constrained than that of other continental areas. The crustal stress field controls processes including earthquake hazard; the stability of mines, tunnels and boreholes, and; fluid flow in groundwater aquifers and oil reservoirs. Using data from oil exploration wells, earthquakes and recent geological activity, this project will increase from around 300 to 1000 the number of rel ....The Australasian Stress Map. The contemporary crustal stress field of Australasia is both more complex and more poorly constrained than that of other continental areas. The crustal stress field controls processes including earthquake hazard; the stability of mines, tunnels and boreholes, and; fluid flow in groundwater aquifers and oil reservoirs. Using data from oil exploration wells, earthquakes and recent geological activity, this project will increase from around 300 to 1000 the number of reliable stress determinations available for Australia, New Zealand and Papua New Guinea. The stress field will be modelled in order to improve our understanding of its origin and variability.Read moreRead less
The study and development of a 3D real-time stockpile management system. By successfully completing this project, the efficiency of existing infrastructure investments in industries involved in bulk material handling (inclusive of minerals, grain, sugar and woodchips) will be largely improved. This will allow such industries to contain costs and thus increase international competitiveness. Efficiencies gains (in these industries) to date have been in recover and processing with little attention ....The study and development of a 3D real-time stockpile management system. By successfully completing this project, the efficiency of existing infrastructure investments in industries involved in bulk material handling (inclusive of minerals, grain, sugar and woodchips) will be largely improved. This will allow such industries to contain costs and thus increase international competitiveness. Efficiencies gains (in these industries) to date have been in recover and processing with little attention to stockyard and movement within the stockyards. The industries sectors in which will receive the greatest benefits are in rural and remote Australia. There is also the ability of the system to be exported to overseas clients, particularly in the mining sector.Read moreRead less
A Novel Metabolic Role For UDP Glycosyltransferase 8 (UGT8)
Funder
National Health and Medical Research Council
Funding Amount
$419,144.00
Summary
The UDP glycosyltransferases (UGTs) are a family of enzymes that remove drugs and toxins from the human body as well as control levels of naturally produced molecules such as bile acids and hormones. We found that a new member of this family called UGT8 processes bile acids in the kidney and intestine and can affect how bile acids act to regulate metabolism. Our studies uncover new roles for bile acids in liver, kidney and gut health and in metabolic disorders such as diabetes and obesity.
Use of mitochondrial electron transport chain mutants to evaluate how non-phosphorylating respiration influences plant metabolite profiles and stress tolerance. This project uses transgenic plant technology to elucidate how mitochondrial function impacts on the profile of metabolites in plant cell and tissues and whether altering these profiles influences a plant's ability tog row in harsh conditions. It will contribute to our fundamental knowledge of plant metabolism using a metabolomic anaylsi ....Use of mitochondrial electron transport chain mutants to evaluate how non-phosphorylating respiration influences plant metabolite profiles and stress tolerance. This project uses transgenic plant technology to elucidate how mitochondrial function impacts on the profile of metabolites in plant cell and tissues and whether altering these profiles influences a plant's ability tog row in harsh conditions. It will contribute to our fundamental knowledge of plant metabolism using a metabolomic anaylsis of plant stress response. This will be achieved using new high-throughput technologies, allowing reliable qualitative and quantitative analysis of large numbers of samples. This approach will compliment existing genomic and proteomic analyses of plants exposed to abiotic stress.Read moreRead less
Cluster hardening of metastable steel alloys produced by thin strip casting. The goal of this project is to generate sufficient knowledge to apply strip casting to a wider range of steel grades and reduce the global energy cost of steel sheet production. Over 1 billion tonnes of steel is produced every year. Direct strip casting is an emerging green technology that reduces the energy required to process liquid steel into thin sheet product by up to 90 per cent. This study plans to use advanced a ....Cluster hardening of metastable steel alloys produced by thin strip casting. The goal of this project is to generate sufficient knowledge to apply strip casting to a wider range of steel grades and reduce the global energy cost of steel sheet production. Over 1 billion tonnes of steel is produced every year. Direct strip casting is an emerging green technology that reduces the energy required to process liquid steel into thin sheet product by up to 90 per cent. This study plans to use advanced atomic-scale characterisation techniques such as atom probe tomography and high-resolution electron microscopy to understand the non-equilibrium microstructures that develop as a result of the extremely rapid cooling rates experienced during strip casting.Read moreRead less