Experimental and empirical insight into melting of the early Earth's mantle. The early Earth's mantle produced melt at much higher temperature than today, creating rocks with unique chemistries and mineralogies. But pressing knowledge gaps about hot mantle melting remain. The aim of this project is to generate new experimental and empirical knowledge to help closing these gaps by:
(i) conducting high pressure experiments to refine phase-composition relationships and element partitioning;
(ii) qu ....Experimental and empirical insight into melting of the early Earth's mantle. The early Earth's mantle produced melt at much higher temperature than today, creating rocks with unique chemistries and mineralogies. But pressing knowledge gaps about hot mantle melting remain. The aim of this project is to generate new experimental and empirical knowledge to help closing these gaps by:
(i) conducting high pressure experiments to refine phase-composition relationships and element partitioning;
(ii) quantifying mineral fabrics in cratonic peridotites to understand the movement of early continents; and
(iii) constructing the first petrological deep time model for greenstone belt volcanic rocks.
The expected outcomes are better models for the early Earth's melting and tectonic regimes and insight into the emergence of land.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100047
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Events through time: eruptions, extinctions, impacts, ore-bodies and orogenies - upgrading the national argon geochronology network. Nine universities and the CSIRO will replace aged and obsolete equipment with new mass spectrometers which will be strategically placed at opposite ends of our continent to improve access for Australian researchers to these instruments for which there is high demand. These instruments will allow more exact dating of events such as eruptions, impacts, climate change ....Events through time: eruptions, extinctions, impacts, ore-bodies and orogenies - upgrading the national argon geochronology network. Nine universities and the CSIRO will replace aged and obsolete equipment with new mass spectrometers which will be strategically placed at opposite ends of our continent to improve access for Australian researchers to these instruments for which there is high demand. These instruments will allow more exact dating of events such as eruptions, impacts, climate change, biological extinctions, mineral deposits and mountain building.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100112
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
A Raman facility for advanced research supporting Australia’s natural gas, oil, coal and minerals industries. This modern Raman Spectroscopy facility will support the science and engineering that underpins the production and processing of Australia’s natural resources. Using high-pressure fibre optics, novel lasers and advanced imaging, the facility will enable the monitoring and improvement of processes and materials under extreme conditions.
Examination Of The Molecular Pharmacology Of Anthracyclines Induced Via Their Interaction With Iron
Funder
National Health and Medical Research Council
Funding Amount
$618,401.00
Summary
Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and ....Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and haem synthesis. Hence, this effect probably contributes to the cytotoxic activity of anthracyclines on the heart. We showed that novel drugs developed in my lab that bind Fe called chelators show high activity in animals (DR4) and prevent anthracycline-mediated Fe accumulation in ferritin. Importantly, Fe chelators have been shown to inhibit anthracycline-mediated cardiotoxicity. Indeed, the clinically used cardioprotective agent, ICRF-187, is actually an Fe chelator (5, DR6). However, ICRF-187 is not totally successful in terms of its cardioprotective effects and can cause myelosuppression (5, DR6). While the clinically used chelator, desferrioxamine (DFO), can prevent anthracycline-mediated cardiotoxicity, its poor membrane permeability limits its effectiveness. Our chelators are highly permeable and overcome the disadvantages of DFO (DR4). Thus, they are vital to examine for preventing anthracycline-mediated cardiotoxicity. In this proposal we will examine the changes in Fe metabolism induced by anthracyclines and test the hypothesis that novel Fe chelators may prevent the cardiotoxicity of these agents. We also aim to be the first to assess if preparation of anthracyclines which cannot bind iron prevents their cardiotoxicity. This will be done by preparing metal complexes of these drugs which prevent Fe-binding eg. anthracycline-zinc complexes. These studies are important for the development of less cardiotoxic forms of these very useful anti-tumour agents.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100065
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
A fully automated, fully shielded palaeomagnetic system. A fully automated, fully shielded palaeomagnetic system: This project aims to establish the first fully automated and magnetically fully shielded superconducting palaeomagnetic data acquisition system in Australia. Palaeomagnetism is a key research field that has applications to a broad range of pure and applied geoscience disciplines. Australia has been a world leader in this field, including the application of palaeomagnetism to both glo ....A fully automated, fully shielded palaeomagnetic system. A fully automated, fully shielded palaeomagnetic system: This project aims to establish the first fully automated and magnetically fully shielded superconducting palaeomagnetic data acquisition system in Australia. Palaeomagnetism is a key research field that has applications to a broad range of pure and applied geoscience disciplines. Australia has been a world leader in this field, including the application of palaeomagnetism to both global and regional tectonic studies. Palaeomagnetic studies demand a labour-intensive process of treating and measuring a large number of samples. The system will significantly enhance the efficiency and accuracy of palaeomagnetic analysis, and thus enhance Australia's research capacity in this and related research fields.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC230100035
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Training Centre in Critical Resources for the Future. The proposed ARC Training Centre in Critical Resources aims to train the next generation of geoscientists needed to enable resourcing of the transition to a high-tech, clean energy society. Training of PhD students and postdoctoral scientists will primarily focus on bridging the gap between mineral systems science, mineral exploration protocols and ore processing/metallurgical extraction. This will provide geoscientists with an essential ....ARC Training Centre in Critical Resources for the Future. The proposed ARC Training Centre in Critical Resources aims to train the next generation of geoscientists needed to enable resourcing of the transition to a high-tech, clean energy society. Training of PhD students and postdoctoral scientists will primarily focus on bridging the gap between mineral systems science, mineral exploration protocols and ore processing/metallurgical extraction. This will provide geoscientists with an essential understanding of the whole value chain of the critical resources of the future.
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Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Enabling three dimensional stochastic geological modelling. This project aims to develop technologies to mitigate three dimensional (3D) geological risk in resources management. This project expects to create new knowledge and methods in the field of 3D geological modelling through the innovative application of mathematical methods, structural geology concepts and probabilistic programming. The expected outcomes are an enhanced capability to model the subsurface, characterise model uncertainty a ....Enabling three dimensional stochastic geological modelling. This project aims to develop technologies to mitigate three dimensional (3D) geological risk in resources management. This project expects to create new knowledge and methods in the field of 3D geological modelling through the innovative application of mathematical methods, structural geology concepts and probabilistic programming. The expected outcomes are an enhanced capability to model the subsurface, characterise model uncertainty and test multiple geological scenarios. This enhanced capability is important for the future of Australia's subsurface management, including urban geology and our continuously growing sustainable resources industry.Read moreRead less
From organo-mineral nanocomposite to Australian basins; an integrated approach to unconventional gas exploration and development. Gas production from unconventional shale reservoirs is a potential major energy boom in Australia that will lower carbon emissions over comparable coal and oil use. The geological controls of shale are currently too poorly understood to direct effective exploration. This project will be the largest international effort to develop this knowledge.
Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing an ....Data-driven monitoring of raceway dynamics in ironmaking blast furnaces. Raceway dynamics in ironmaking blast furnaces affect operational stability and cost considerably, yet their dynamic behaviour has not been well monitored online. The project aims to develop a data-driven model for monitoring the internal state of gas-solid-powder reacting flow in the raceway and predicting raceway anomalies online. It will be achieved by combining particle-fluid numerical simulations with data processing and reduced-order state observer, supported by lab/plant experiments, and collaborating with two industry partners from coal and steel industries. The project outcomes including codes, models and raceway control strategies can help promote Australian metallurgical coal's global markets and ultimately the Australian economy.Read moreRead less