Four dimensional lithospheric evolution and controls on mineral system distribution in Neoarchean to Paleoproterozoic terranes. This project will resolve important questions about the links between the evolution and preservation of continents and important mineral deposits in Australia and West Africa between 2.7 and 1.8 billion years ago. The results will improve the understanding of a key period of Earth history and make a major contribution to mineral exploration.
The lost ocean of eastern Australia and its critical metals endowment. This project aims to unravel the tectonic origin and economic potential of ultramafic rocks (rocks which host elevated concentrations of nickel, cobalt, chromium, and platinum-group elements). Such rocks are outcropping in eastern Australia along a contorted ~1500 km long belt that may record relics of an ancient ocean. Through detailed mapping and cutting-edge analytical techniques, the project is expected to fill a crucial ....The lost ocean of eastern Australia and its critical metals endowment. This project aims to unravel the tectonic origin and economic potential of ultramafic rocks (rocks which host elevated concentrations of nickel, cobalt, chromium, and platinum-group elements). Such rocks are outcropping in eastern Australia along a contorted ~1500 km long belt that may record relics of an ancient ocean. Through detailed mapping and cutting-edge analytical techniques, the project is expected to fill a crucial knowledge gap in Australian tectonics, while providing information on ore mineralisation. The expected outcomes, including new tectonic models unveiling the scale, geometry, and economic potential of the ultramafic bodies, could benefit critical mineral exploration, carbon storage solutions, and geoecology conservation.Read moreRead less
Experimental and empirical insight into melting of the early Earth's mantle. The early Earth's mantle produced melt at much higher temperature than today, creating rocks with unique chemistries and mineralogies. But pressing knowledge gaps about hot mantle melting remain. The aim of this project is to generate new experimental and empirical knowledge to help closing these gaps by:
(i) conducting high pressure experiments to refine phase-composition relationships and element partitioning;
(ii) qu ....Experimental and empirical insight into melting of the early Earth's mantle. The early Earth's mantle produced melt at much higher temperature than today, creating rocks with unique chemistries and mineralogies. But pressing knowledge gaps about hot mantle melting remain. The aim of this project is to generate new experimental and empirical knowledge to help closing these gaps by:
(i) conducting high pressure experiments to refine phase-composition relationships and element partitioning;
(ii) quantifying mineral fabrics in cratonic peridotites to understand the movement of early continents; and
(iii) constructing the first petrological deep time model for greenstone belt volcanic rocks.
The expected outcomes are better models for the early Earth's melting and tectonic regimes and insight into the emergence of land.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100099
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
New horizons in geochemical isotopic analysis with a new-generation multicollector plasma mass spectrometer: towards unravelling the deep earth system. A new-generation plasma mass spectrometer will let us develop novel applications in geochemistry to better understand Earth processes. This will enhance Australian Geosciences’ high international profile, and help attract high-quality researchers to attack problems relevant to the Deep Earth Resources National Priority and mineral exploration.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100047
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Events through time: eruptions, extinctions, impacts, ore-bodies and orogenies - upgrading the national argon geochronology network. Nine universities and the CSIRO will replace aged and obsolete equipment with new mass spectrometers which will be strategically placed at opposite ends of our continent to improve access for Australian researchers to these instruments for which there is high demand. These instruments will allow more exact dating of events such as eruptions, impacts, climate change ....Events through time: eruptions, extinctions, impacts, ore-bodies and orogenies - upgrading the national argon geochronology network. Nine universities and the CSIRO will replace aged and obsolete equipment with new mass spectrometers which will be strategically placed at opposite ends of our continent to improve access for Australian researchers to these instruments for which there is high demand. These instruments will allow more exact dating of events such as eruptions, impacts, climate change, biological extinctions, mineral deposits and mountain building.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100112
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
A Raman facility for advanced research supporting Australia’s natural gas, oil, coal and minerals industries. This modern Raman Spectroscopy facility will support the science and engineering that underpins the production and processing of Australia’s natural resources. Using high-pressure fibre optics, novel lasers and advanced imaging, the facility will enable the monitoring and improvement of processes and materials under extreme conditions.
The Missing link in the Tasmanides: evaluating tectonic evolution and resource exploration potential of the southern Thomson Fold belt. Understanding the Thomson Orogen, a geological region which straddles the New South Wales and Queensland border, is critical for developing geodynamic models for the evolution of eastern Australia, and assessing resource potential. However, it lies under the Great Artesian Basin. This project focusses on ground truthing geophysical acquisition studies using dril ....The Missing link in the Tasmanides: evaluating tectonic evolution and resource exploration potential of the southern Thomson Fold belt. Understanding the Thomson Orogen, a geological region which straddles the New South Wales and Queensland border, is critical for developing geodynamic models for the evolution of eastern Australia, and assessing resource potential. However, it lies under the Great Artesian Basin. This project focusses on ground truthing geophysical acquisition studies using drill core from a targeted drilling program, designed to maximise the available tectono-stratigraphic information. The outcome intends to be a 3D geological map of the region, which can be interrogated for mineral exploration targeting, and from which 4D evolutionary geodynamic models of eastern Australian can be integrated.Read moreRead less
Examination Of The Molecular Pharmacology Of Anthracyclines Induced Via Their Interaction With Iron
Funder
National Health and Medical Research Council
Funding Amount
$618,401.00
Summary
Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and ....Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and haem synthesis. Hence, this effect probably contributes to the cytotoxic activity of anthracyclines on the heart. We showed that novel drugs developed in my lab that bind Fe called chelators show high activity in animals (DR4) and prevent anthracycline-mediated Fe accumulation in ferritin. Importantly, Fe chelators have been shown to inhibit anthracycline-mediated cardiotoxicity. Indeed, the clinically used cardioprotective agent, ICRF-187, is actually an Fe chelator (5, DR6). However, ICRF-187 is not totally successful in terms of its cardioprotective effects and can cause myelosuppression (5, DR6). While the clinically used chelator, desferrioxamine (DFO), can prevent anthracycline-mediated cardiotoxicity, its poor membrane permeability limits its effectiveness. Our chelators are highly permeable and overcome the disadvantages of DFO (DR4). Thus, they are vital to examine for preventing anthracycline-mediated cardiotoxicity. In this proposal we will examine the changes in Fe metabolism induced by anthracyclines and test the hypothesis that novel Fe chelators may prevent the cardiotoxicity of these agents. We also aim to be the first to assess if preparation of anthracyclines which cannot bind iron prevents their cardiotoxicity. This will be done by preparing metal complexes of these drugs which prevent Fe-binding eg. anthracycline-zinc complexes. These studies are important for the development of less cardiotoxic forms of these very useful anti-tumour agents.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100065
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
A fully automated, fully shielded palaeomagnetic system. A fully automated, fully shielded palaeomagnetic system: This project aims to establish the first fully automated and magnetically fully shielded superconducting palaeomagnetic data acquisition system in Australia. Palaeomagnetism is a key research field that has applications to a broad range of pure and applied geoscience disciplines. Australia has been a world leader in this field, including the application of palaeomagnetism to both glo ....A fully automated, fully shielded palaeomagnetic system. A fully automated, fully shielded palaeomagnetic system: This project aims to establish the first fully automated and magnetically fully shielded superconducting palaeomagnetic data acquisition system in Australia. Palaeomagnetism is a key research field that has applications to a broad range of pure and applied geoscience disciplines. Australia has been a world leader in this field, including the application of palaeomagnetism to both global and regional tectonic studies. Palaeomagnetic studies demand a labour-intensive process of treating and measuring a large number of samples. The system will significantly enhance the efficiency and accuracy of palaeomagnetic analysis, and thus enhance Australia's research capacity in this and related research fields.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH230100010
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC Research Hub for Smart Process Design and Control . ARC Research Hub for Smart Process Design and Control aims to develop and apply advanced computational technologies to model and optimise complex multiphase processes by integrating the novel multiscale and AI modelling approaches. The outcomes include theories, computer models and simulation techniques, advanced knowledge about process modelling and optimisation, innovative technologies and processes for low carbon operations, and tens of ....ARC Research Hub for Smart Process Design and Control . ARC Research Hub for Smart Process Design and Control aims to develop and apply advanced computational technologies to model and optimise complex multiphase processes by integrating the novel multiscale and AI modelling approaches. The outcomes include theories, computer models and simulation techniques, advanced knowledge about process modelling and optimisation, innovative technologies and processes for low carbon operations, and tens of postdoc and PhD students through academic, industrial and international collaboration. Their application will significantly improve energy/process efficiency and reduce CO2 emission. The Hub will generate a significant impact on the mineral and metallurgical industries which are important to Australia.Read moreRead less