Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100070
Funder
Australian Research Council
Funding Amount
$966,283.00
Summary
Cutting-edge electron probe microanalysis driving Western Australia’s resource geosciences. This project aims to provide a new generation electron microprobe, with advances in trace element mapping and cathodoluminescence analysis to enable superior characterisation of a wide range of materials. The overwhelming demand for electron probe microanalysis from research groups in Western Australia requires renewal of over-subscribed, ageing facilities to drive innovation and alleviate bottlenecks in ....Cutting-edge electron probe microanalysis driving Western Australia’s resource geosciences. This project aims to provide a new generation electron microprobe, with advances in trace element mapping and cathodoluminescence analysis to enable superior characterisation of a wide range of materials. The overwhelming demand for electron probe microanalysis from research groups in Western Australia requires renewal of over-subscribed, ageing facilities to drive innovation and alleviate bottlenecks in advanced geosciences multi-capability workflows. The electron probe will drive underpinning geoscience, resources science and economic geology, as well as support a broad range of disciplines and diverse fields, such as nanotechnology, microelectronics and aquatic sciences.Read moreRead less
Resolving the influence of intraplate orogenesis on continental margin tectonics. Novel, multi-dating of continental sedimentary rocks will be undertaken to examine the effects of a high sediment flux from an enigmatic, major mountain-building event on a distant continental margin. This will expand our understanding of the range of tectonic influences between continental interiors and margins and onshore resource potential.
Resolving the mystery of how rare earth elements are mobilised and concentrated in continental crust. Rare earth elements are regarded as the vitamins for modern industries and technologies. This project will investigate the geological processes that mobilise and concentrate these elements in the Earth's crust. The results will aid discovery of new ore deposits, which is essential to meet rapidly growing demand for these elements.
Nature's mechanisms for leaching and remobilising metals. This project aims to understand the chemical and physical processes that govern reactive transport and metal scavenging in rocky environments. Much of Australia's mineral wealth is the result of the interaction of warm fluids with rocks deep in the Earth over geological timescales. The formation of ore deposits is governed by the physical chemistry of mineral dissolution and crystallisation, and by fluid flow through porous rocks and frac ....Nature's mechanisms for leaching and remobilising metals. This project aims to understand the chemical and physical processes that govern reactive transport and metal scavenging in rocky environments. Much of Australia's mineral wealth is the result of the interaction of warm fluids with rocks deep in the Earth over geological timescales. The formation of ore deposits is governed by the physical chemistry of mineral dissolution and crystallisation, and by fluid flow through porous rocks and fractures. This project integrates innovation in geology, chemistry, and mineral engineering, and will deliver mineral-scale reaction models that will increase efficiency of in-situ mining and leaching technologies. Knowledge generated can be applied to improve mineral exploration, mining, and processing, contributing to unlocking billions of dollars’ worth of resources tied up in low grade, mineralogically complex ores.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100047
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Events through time: eruptions, extinctions, impacts, ore-bodies and orogenies - upgrading the national argon geochronology network. Nine universities and the CSIRO will replace aged and obsolete equipment with new mass spectrometers which will be strategically placed at opposite ends of our continent to improve access for Australian researchers to these instruments for which there is high demand. These instruments will allow more exact dating of events such as eruptions, impacts, climate change ....Events through time: eruptions, extinctions, impacts, ore-bodies and orogenies - upgrading the national argon geochronology network. Nine universities and the CSIRO will replace aged and obsolete equipment with new mass spectrometers which will be strategically placed at opposite ends of our continent to improve access for Australian researchers to these instruments for which there is high demand. These instruments will allow more exact dating of events such as eruptions, impacts, climate change, biological extinctions, mineral deposits and mountain building.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100112
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
A Raman facility for advanced research supporting Australia’s natural gas, oil, coal and minerals industries. This modern Raman Spectroscopy facility will support the science and engineering that underpins the production and processing of Australia’s natural resources. Using high-pressure fibre optics, novel lasers and advanced imaging, the facility will enable the monitoring and improvement of processes and materials under extreme conditions.
Biogeochemistry of ferruginous duricrusts. The project is focussed on the examination and application of microbial iron cycling in the formation of geologically stable, iron duricrusts in tropical regimes. The aim of the project is to develop a site-scale bioremediation strategy for iron ore mines by re-establishing canga, which are ‘ancient’ distinct ecosystems possessing unique plant species rarely found on Earth. This university-industry collaboration aims to produce economic benefits for the ....Biogeochemistry of ferruginous duricrusts. The project is focussed on the examination and application of microbial iron cycling in the formation of geologically stable, iron duricrusts in tropical regimes. The aim of the project is to develop a site-scale bioremediation strategy for iron ore mines by re-establishing canga, which are ‘ancient’ distinct ecosystems possessing unique plant species rarely found on Earth. This university-industry collaboration aims to produce economic benefits for the world’s iron mining industry through advanced training in mining-related research, and through the completion of the mining life cycle by site remediation, enhancing Australia’s position as a global leader in providing innovative solutions to today’s mining challenges.Read moreRead less
Examination Of The Molecular Pharmacology Of Anthracyclines Induced Via Their Interaction With Iron
Funder
National Health and Medical Research Council
Funding Amount
$618,401.00
Summary
Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and ....Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and haem synthesis. Hence, this effect probably contributes to the cytotoxic activity of anthracyclines on the heart. We showed that novel drugs developed in my lab that bind Fe called chelators show high activity in animals (DR4) and prevent anthracycline-mediated Fe accumulation in ferritin. Importantly, Fe chelators have been shown to inhibit anthracycline-mediated cardiotoxicity. Indeed, the clinically used cardioprotective agent, ICRF-187, is actually an Fe chelator (5, DR6). However, ICRF-187 is not totally successful in terms of its cardioprotective effects and can cause myelosuppression (5, DR6). While the clinically used chelator, desferrioxamine (DFO), can prevent anthracycline-mediated cardiotoxicity, its poor membrane permeability limits its effectiveness. Our chelators are highly permeable and overcome the disadvantages of DFO (DR4). Thus, they are vital to examine for preventing anthracycline-mediated cardiotoxicity. In this proposal we will examine the changes in Fe metabolism induced by anthracyclines and test the hypothesis that novel Fe chelators may prevent the cardiotoxicity of these agents. We also aim to be the first to assess if preparation of anthracyclines which cannot bind iron prevents their cardiotoxicity. This will be done by preparing metal complexes of these drugs which prevent Fe-binding eg. anthracycline-zinc complexes. These studies are important for the development of less cardiotoxic forms of these very useful anti-tumour agents.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100065
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
A fully automated, fully shielded palaeomagnetic system. A fully automated, fully shielded palaeomagnetic system: This project aims to establish the first fully automated and magnetically fully shielded superconducting palaeomagnetic data acquisition system in Australia. Palaeomagnetism is a key research field that has applications to a broad range of pure and applied geoscience disciplines. Australia has been a world leader in this field, including the application of palaeomagnetism to both glo ....A fully automated, fully shielded palaeomagnetic system. A fully automated, fully shielded palaeomagnetic system: This project aims to establish the first fully automated and magnetically fully shielded superconducting palaeomagnetic data acquisition system in Australia. Palaeomagnetism is a key research field that has applications to a broad range of pure and applied geoscience disciplines. Australia has been a world leader in this field, including the application of palaeomagnetism to both global and regional tectonic studies. Palaeomagnetic studies demand a labour-intensive process of treating and measuring a large number of samples. The system will significantly enhance the efficiency and accuracy of palaeomagnetic analysis, and thus enhance Australia's research capacity in this and related research fields.Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.