Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100047
Funder
Australian Research Council
Funding Amount
$420,000.00
Summary
Events through time: eruptions, extinctions, impacts, ore-bodies and orogenies - upgrading the national argon geochronology network. Nine universities and the CSIRO will replace aged and obsolete equipment with new mass spectrometers which will be strategically placed at opposite ends of our continent to improve access for Australian researchers to these instruments for which there is high demand. These instruments will allow more exact dating of events such as eruptions, impacts, climate change ....Events through time: eruptions, extinctions, impacts, ore-bodies and orogenies - upgrading the national argon geochronology network. Nine universities and the CSIRO will replace aged and obsolete equipment with new mass spectrometers which will be strategically placed at opposite ends of our continent to improve access for Australian researchers to these instruments for which there is high demand. These instruments will allow more exact dating of events such as eruptions, impacts, climate change, biological extinctions, mineral deposits and mountain building.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100112
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
A Raman facility for advanced research supporting Australia’s natural gas, oil, coal and minerals industries. This modern Raman Spectroscopy facility will support the science and engineering that underpins the production and processing of Australia’s natural resources. Using high-pressure fibre optics, novel lasers and advanced imaging, the facility will enable the monitoring and improvement of processes and materials under extreme conditions.
Examination Of The Molecular Pharmacology Of Anthracyclines Induced Via Their Interaction With Iron
Funder
National Health and Medical Research Council
Funding Amount
$618,401.00
Summary
Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and ....Anthracyclines are highly effective anti-cancer drugs, but their use is limited by toxic effects on the heart. This is thought to be due to these drugs directly binding iron (Fe). Indeed, we showed that anthracyclines induced marked changes in the way heart cells utilise Fe (DR1-3, 38; Mol. Pharmacol. 2002, 2003, 2004, 2005). We were the first to show that anthracyclines prevent Fe release from the criticial Fe storage protein ferritin. This prevents the use of Fe for vital processes eg. DNA and haem synthesis. Hence, this effect probably contributes to the cytotoxic activity of anthracyclines on the heart. We showed that novel drugs developed in my lab that bind Fe called chelators show high activity in animals (DR4) and prevent anthracycline-mediated Fe accumulation in ferritin. Importantly, Fe chelators have been shown to inhibit anthracycline-mediated cardiotoxicity. Indeed, the clinically used cardioprotective agent, ICRF-187, is actually an Fe chelator (5, DR6). However, ICRF-187 is not totally successful in terms of its cardioprotective effects and can cause myelosuppression (5, DR6). While the clinically used chelator, desferrioxamine (DFO), can prevent anthracycline-mediated cardiotoxicity, its poor membrane permeability limits its effectiveness. Our chelators are highly permeable and overcome the disadvantages of DFO (DR4). Thus, they are vital to examine for preventing anthracycline-mediated cardiotoxicity. In this proposal we will examine the changes in Fe metabolism induced by anthracyclines and test the hypothesis that novel Fe chelators may prevent the cardiotoxicity of these agents. We also aim to be the first to assess if preparation of anthracyclines which cannot bind iron prevents their cardiotoxicity. This will be done by preparing metal complexes of these drugs which prevent Fe-binding eg. anthracycline-zinc complexes. These studies are important for the development of less cardiotoxic forms of these very useful anti-tumour agents.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100065
Funder
Australian Research Council
Funding Amount
$560,000.00
Summary
A fully automated, fully shielded palaeomagnetic system. A fully automated, fully shielded palaeomagnetic system: This project aims to establish the first fully automated and magnetically fully shielded superconducting palaeomagnetic data acquisition system in Australia. Palaeomagnetism is a key research field that has applications to a broad range of pure and applied geoscience disciplines. Australia has been a world leader in this field, including the application of palaeomagnetism to both glo ....A fully automated, fully shielded palaeomagnetic system. A fully automated, fully shielded palaeomagnetic system: This project aims to establish the first fully automated and magnetically fully shielded superconducting palaeomagnetic data acquisition system in Australia. Palaeomagnetism is a key research field that has applications to a broad range of pure and applied geoscience disciplines. Australia has been a world leader in this field, including the application of palaeomagnetism to both global and regional tectonic studies. Palaeomagnetic studies demand a labour-intensive process of treating and measuring a large number of samples. The system will significantly enhance the efficiency and accuracy of palaeomagnetic analysis, and thus enhance Australia's research capacity in this and related research fields.Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
From organo-mineral nanocomposite to Australian basins; an integrated approach to unconventional gas exploration and development. Gas production from unconventional shale reservoirs is a potential major energy boom in Australia that will lower carbon emissions over comparable coal and oil use. The geological controls of shale are currently too poorly understood to direct effective exploration. This project will be the largest international effort to develop this knowledge.
ARC Centre of Excellence - in Ore Deposits. Australia's minerals industry faces a two-fold challenge - to find new ore deposits and to mine them with maximum efficiency and minimal environmental impact. Those challenges demand a new generation of focused ore deposit research, tailored specifically for the Australian context. The Centre of Excellence in Ore Deposits will provide the foundation of fundamental research required by a successful, efficient and sustainable Australian minerals industry ....ARC Centre of Excellence - in Ore Deposits. Australia's minerals industry faces a two-fold challenge - to find new ore deposits and to mine them with maximum efficiency and minimal environmental impact. Those challenges demand a new generation of focused ore deposit research, tailored specifically for the Australian context. The Centre of Excellence in Ore Deposits will provide the foundation of fundamental research required by a successful, efficient and sustainable Australian minerals industry. The Centre will also play a leading role in the undergraduate and postgraduate training of future geoscientists. The concentration of internationally recognised researchers in the Centre will ensure it maintains its premier position in the international ore deposit research arena.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100067
Funder
Australian Research Council
Funding Amount
$10,000,000.00
Summary
Australian Membership of the International Ocean Discovery Program. Australian membership of the International Ocean Discovery Program:
This project is for a 5-year membership of the International Ocean Discovery Program, the world’s largest collaborative research program in earth and ocean sciences addressing international priorities. The program conducts seagoing coring expeditions and monitoring of instrumented boreholes to study the history and current activity of the Earth, recorded in sed ....Australian Membership of the International Ocean Discovery Program. Australian membership of the International Ocean Discovery Program:
This project is for a 5-year membership of the International Ocean Discovery Program, the world’s largest collaborative research program in earth and ocean sciences addressing international priorities. The program conducts seagoing coring expeditions and monitoring of instrumented boreholes to study the history and current activity of the Earth, recorded in sediments and rocks below the seafloor. The program’s aims include understanding past global environments on multiple time scales, the deep biosphere, plate tectonics, occurrence and distribution of resources, and generation of hazards. Several multinational expeditions are scheduled and planned in our marine jurisdiction and within the Australasian region. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100013
Funder
Australian Research Council
Funding Amount
$860,000.00
Summary
Laser ablation multiple split streaming. Laser ablation multiple split streaming: This geochemical facility with an innovative, world-leading micro-analytical capability intends to support research of fundamental and strategic problems at the frontiers of the Earth and Environmental Sciences. The facility aims to allow new insight into the age, composition, thermal history and structure of the Australian continent, as necessary for delineating mineral endowment and for tracing the sources of ore ....Laser ablation multiple split streaming. Laser ablation multiple split streaming: This geochemical facility with an innovative, world-leading micro-analytical capability intends to support research of fundamental and strategic problems at the frontiers of the Earth and Environmental Sciences. The facility aims to allow new insight into the age, composition, thermal history and structure of the Australian continent, as necessary for delineating mineral endowment and for tracing the sources of ore metals. It will provide a higher resolution record of climate and environmental change which will better inform assessment of the impacts, both locally and regionally. It is intended that the facility will amplify national and international scientific collaboration and create unique research opportunities for Australian-based scientists.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100218
Funder
Australian Research Council
Funding Amount
$254,078.00
Summary
A world-class rock magnetic facility to support Australian palaeomagnetic and environmental research. Magnetic properties of rocks and environmental particles provide information about a vast range of geological and environmental processes. We propose to develop a facility that will enable detection and interpretation of these magnetic signals to aid understanding of climate change, mineral exploration, and the geological development of Australia.