The Pathway Linking Tau And APP In Neurodegeneration
Funder
National Health and Medical Research Council
Funding Amount
$312,085.00
Summary
Recently I co-discovered a novel relationship between the AlzheimerÍs amyloid precursor protein and tau, both of which play a role in regulating neuronal iron levels. I predict that multiple failures in iron-regulating systems could foster a toxic iron accumulation in brain, leading to the development of neurodegenerative diseases. I hope to gain a better understanding of their mechanism of action and propose that this pathway is a target for therapeutic intervention.
Iron-Infection Interactions: Studies Of The Link Between Iron Metabolism And Infectious Diseases Of Global Significance
Funder
National Health and Medical Research Council
Funding Amount
$383,244.00
Summary
Anaemia, malaria and HIV affect millions of people worldwide, but interactions between these conditions are poorly understood. A haematologist with training in public health, my interest is in finding ways to control the enormous global burden of anaemia. My research will focus on how iron status influences infection with malaria and HIV. It will provide evidence for anaemia control guidelines and help improve global policies for controlling iron deficiency where these infections coexist.
Identifying The Mechanisms By Which Ascorbate Stimulates Cellular Iron Uptake From Transferrin.
Funder
National Health and Medical Research Council
Funding Amount
$302,123.00
Summary
Vitamin C (ascorbate)-deficiency leads to anaemia and other symptoms of scurvy. Iron supplementation cannot alone correct this anaemia, with ascorbate being crucial. Almost all iron in plasma is bound to transferrin, and I have recent data showing that ascorbate stimulates transferrin-iron uptake. This research will identify how this stimulation occurs. This work has important biomedical implications for understanding iron uptake and anaemia, which affects 500 million people globally.
Can Nanoparticles Give An Old Iron Chelator A New Life? — Development Of Targeted Polymeric Nanoparticles With Long Half-lives To Treat Iron Overload Diseases
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Iron loading disorders (such as thalassaemia) represent an important class of human disease. As part of the treatment for these diseases, the iron needs to be removed and this is often done using iron-binding drugs known as iron chelators. Current chelators are not ideal due to side effects or onerous delivery methods. The goal of this project is to use nanotechnology to develop more effective ways of delivering chelators to improve their effectiveness and reduce toxicity.
Cellular Response To Modulation Of Iron Levels: Studies Examining ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$33,055.00
Summary
Iron is crucial for many essential biological processes. Recently, I demonstrated that iron-depletion can affects signalling pathways that play important roles in cellular growth and death. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. My proposed research is crucial for understanding: (1) the effects of iron-deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.
Improving The Quality Of Nephrology Care In Rural Australia (INCRA): Implementation Of Key Guidelines Into Clinical Practice In Rural Or Remote Nephrology Practices.