The measurement of primary traits in second language oral proficiency in second language acquisition research. The proposed research will help to inform high-quality learning outcomes for international ESL (English as a Second Language) students and students who study Japanese or Spanish as a second language in Australian universities. Improved effectiveness in current second language teaching pedagogy will result from a deeper understanding of the role that the key language traits (syntactic co ....The measurement of primary traits in second language oral proficiency in second language acquisition research. The proposed research will help to inform high-quality learning outcomes for international ESL (English as a Second Language) students and students who study Japanese or Spanish as a second language in Australian universities. Improved effectiveness in current second language teaching pedagogy will result from a deeper understanding of the role that the key language traits (syntactic complexity, lexical range, accuracy and fluency) play in the attainment of advanced proficiency. Read moreRead less
A Study Of The Molecular Epidemiology And Virulence Determinants Of Enterovirus 71 Strains From The Asia-Pacific Region
Funder
National Health and Medical Research Council
Funding Amount
$286,325.00
Summary
In this study, we aim to understand the reasons for the emergence of epidemics of severe neurological disease due to enterovirus 71 (EV71) in young children of the Asia-Pacific region since 1997, and to develop strategies for disease prevention. EV71 is a human enterovirus closely related to the polioviruses. Most infections with EV71 are trivial, however, they may occasionally result in severe disease, including brainstem encephalitis with a high mortality and acute flaccid paralysis similar to ....In this study, we aim to understand the reasons for the emergence of epidemics of severe neurological disease due to enterovirus 71 (EV71) in young children of the Asia-Pacific region since 1997, and to develop strategies for disease prevention. EV71 is a human enterovirus closely related to the polioviruses. Most infections with EV71 are trivial, however, they may occasionally result in severe disease, including brainstem encephalitis with a high mortality and acute flaccid paralysis similar to poliomyelitis. There has been a large increase in EV71 epidemic activity throughout the Asia-Pacific region since 1997, including a large epidemic in Perth, Western Australia in 1999. These epidemics have resulted in many deaths and cases of severe neurological disability. In view of the severity of EV71 neurological disease and the lack of effective treatments, our research effort needs to focus on prevention through public health surveillance and vaccine development. The major aims of our study are two-fold: 1. To study the origin and evolution of EV71 in the Asia-Pacific region using molecular techniques and to use this information to implement surveillance in Australia and Southeast Asia. It is anticipated that improved surveillance will provide early warning of impending epidemics. 2. To understand the molecular basis of virulence of EV71, with emphasis on the ability of virus to cause severe disease of the central nervous system. This study will have two goals: a. To identify the human cellular receptor of EV71. The ultimate goal of this research will be the development of a small animal model of EV71 encephalitis by constructing a transgenic mouse expressing the human cellular receptor for EV71. b. To construct an infectious cDNA clone of EV71 and to develop genetically defined attenuated strains by mutagenesis of the infectious clone. Mutant strains of EV71 will be tested for replication and virulence in newborn mice and in human neuroblastoma cells.Read moreRead less
Intrinsic Host Antiviral Activity Against Pathogenic Filoviruses
Funder
National Health and Medical Research Council
Funding Amount
$488,754.00
Summary
Bats are a major reservoir for deadly human viruses including Ebola and Marburg virus. In contrast to humans, bats can be infected with these viruses without showing clinical signs of disease. The reason why bats can co-exist with these viruses is unknown. This study will determine if a bat antiviral molecule contributes to limiting virus release compared to the human version that could reveal strategies to prevent and control these deadly viruses in humans.
Discovery Early Career Researcher Award - Grant ID: DE240101070
Funder
Australian Research Council
Funding Amount
$351,135.00
Summary
Modernism's East Asia: Semi-Asiatic Literature and Global Modernity . This project aims to harness two important topics in the humanities: the global significance of culturally hybrid nations for global modernity, and the significance of East Asian Studies for World Literature. It compares the reception of French and Russian literatures in the West and East Asia by examining texts written mainly in English, French, and Japanese. Its expected outcome is a reevaluation of East Asia's role in the c ....Modernism's East Asia: Semi-Asiatic Literature and Global Modernity . This project aims to harness two important topics in the humanities: the global significance of culturally hybrid nations for global modernity, and the significance of East Asian Studies for World Literature. It compares the reception of French and Russian literatures in the West and East Asia by examining texts written mainly in English, French, and Japanese. Its expected outcome is a reevaluation of East Asia's role in the conceptualization of global modernism and modernity in the arts and society. Its innovative methodology combines East Asian Studies, English and French Literature, philosophy, and the history of ideas. It intends to fortify Australia's position in the humanities and increase its understanding of its own diverse history.Read moreRead less
Writing Identity onto the Screen: Subtitles and captions in Japanese media. This project analyses how varieties of language (dialect, gendered speech styles, youth slang) are written onto the screen in audiovisual media as subtitles and impact-captions. It explores the attitudes held by editors, producers and translators towards language which influence this process. It aims to use the Japanese global media, which is well-known for its heavy use of text-on-screen and its rich diversity of langu ....Writing Identity onto the Screen: Subtitles and captions in Japanese media. This project analyses how varieties of language (dialect, gendered speech styles, youth slang) are written onto the screen in audiovisual media as subtitles and impact-captions. It explores the attitudes held by editors, producers and translators towards language which influence this process. It aims to use the Japanese global media, which is well-known for its heavy use of text-on-screen and its rich diversity of language styles, as a case study. This is expected to lead to a greater understanding of textual representation of identity in contemporary digital media.Read moreRead less
The Cultivation of Middle-Class Taste: Reading, Tourism and Education Choices in Urban China. In urban China, high-income professionals and consumers have enormous influence on the development of élite education, travel, and cultural pursuits, but also on the stability of the Party-State. Their choices will materially affect Australian economic strategy, and will impact the socio-political character of the entire region. This project works to support Australian understanding of the tastes, aspir ....The Cultivation of Middle-Class Taste: Reading, Tourism and Education Choices in Urban China. In urban China, high-income professionals and consumers have enormous influence on the development of élite education, travel, and cultural pursuits, but also on the stability of the Party-State. Their choices will materially affect Australian economic strategy, and will impact the socio-political character of the entire region. This project works to support Australian understanding of the tastes, aspirations and national priorities of this new formation: the Chinese middle class. The approach and outcomes of the research will enhance Australia's global position in innovative, relevant Asian scholarship, support good economic strategy, and provide an accurate socio-cultural lens through which to engage with Chinese and regional futures.Read moreRead less
Harnessing Tyrosine Metabolism To Combat Respiratory Diseases
Funder
National Health and Medical Research Council
Funding Amount
$866,467.00
Summary
Cross-talk between our immune system and the microbiome is central to health and disease. In particular, the gut microbiome has wide-ranging effects throughout the body, in part through the production of metabolites with immunomodulatory activity. We have discovered a novel subset of microbial metabolites which can protect mice against allergic airway inflammation, a model of asthma. We now aim to discovery how these metabolites work with a view towards developing them as therapeutics.
THE IMMUNOLOGICAL LEGACY OF OBESITY ON VIRAL PATHOGENESIS
Funder
National Health and Medical Research Council
Funding Amount
$652,275.00
Summary
Obesity is a key risk factor for severe viral infections. Our preliminary data suggest that in mice this susceptibility is not reduced by weight loss. In this grant we will investigate a) the mechanisms driving the legacy effect of obesity on antiviral immunity b) whether or not we can reverse this legacy effect by treatment with the drug MCC950 and c) the antiviral response of overweight children and adults who have and haven't recently lost weight.
Understanding Influenza-specific T Cell Immunity In The Indigenous Population
Funder
National Health and Medical Research Council
Funding Amount
$870,112.00
Summary
Hospitalisation and death rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. T cells recognising conserved viral regions can elicit such protection. As T cells are restricted by proteins called HLAs, variable between different ethnicities, we will define T cell regions and their HLA restrictions in the Indigenous population to propose strategies for universal T cell-based protecti ....Hospitalisation and death rates from influenza are high in the Indigenous population. There is an urgent need for one-shot universal vaccine that protects against seasonal and pandemic strains. T cells recognising conserved viral regions can elicit such protection. As T cells are restricted by proteins called HLAs, variable between different ethnicities, we will define T cell regions and their HLA restrictions in the Indigenous population to propose strategies for universal T cell-based protective immunity and vaccine design against influenza.Read moreRead less
Dissecting The Central Organisation Of Cough Neural Networks
Funder
National Health and Medical Research Council
Funding Amount
$880,928.00
Summary
Cough is the most prevalent symptom of lung disease and the most common reason for people to seek medical advice. However, cough neural processes are poorly defined and as a result current cough therapies are largely ineffective making cough a significant unmet clinical problem. This project will novel viral strategies to dissect and manipulate cough neural pathways in the brain, providing insights into the neural processing of airway sensations and coughing.