Regulation Of Key Pathways Causing Peri-implant Bone Loss.
Funder
National Health and Medical Research Council
Funding Amount
$403,639.00
Summary
The failure of bone prostheses is becoming a major health problem in our aging population. Despite the impressive success of joint replacement surgery, a significant number of arthroplasties fail. It is now apparent that most implants fail due to bone loss around them which leads to loosening. This project aims to obtain a better understanding of the causes of implant failure and find ways to extend the life of these implants .
Stress Evaluation with Non-Linear Guided Waves. This project plans to investigate a novel approach for in situ measurement of stress in structures based on an internal resonance phenomenon for nonlinear guided waves. Monitoring the stress level of critical structural components is important to ensure structural safety. The project plans to derive the requirements for this internal resonance and its dependence on stress analytically and verify them experimentally for both simple waveguides and mo ....Stress Evaluation with Non-Linear Guided Waves. This project plans to investigate a novel approach for in situ measurement of stress in structures based on an internal resonance phenomenon for nonlinear guided waves. Monitoring the stress level of critical structural components is important to ensure structural safety. The project plans to derive the requirements for this internal resonance and its dependence on stress analytically and verify them experimentally for both simple waveguides and more realistic structures. The expected outcome is the demonstration of the feasibility of a new inexpensive method for continuous monitoring of applied or thermally-induced stresses, which is of great importance in several engineering contexts, such as modern railway track rails, pipelines or pre-stressed strands in concrete structures.Read moreRead less
Impaired Bone Remodelling Leads To Failure Of Orthopaedic Prostheses
Funder
National Health and Medical Research Council
Funding Amount
$515,917.00
Summary
The failure of bone prostheses is becoming a major health problem. More than 26,000 hip, and an equal number of knee, replacements were performed in Australia in 2002 with the number increasing between 5%-10% each year for the previous 10 years. Disturbingly, the incidence of revision hip surgery in Australia is now more than 15%, meaning that, despite the impressive success of joint replacement surgery, a significant number of arthroplasties fail. It is becoming more common for young, active in ....The failure of bone prostheses is becoming a major health problem. More than 26,000 hip, and an equal number of knee, replacements were performed in Australia in 2002 with the number increasing between 5%-10% each year for the previous 10 years. Disturbingly, the incidence of revision hip surgery in Australia is now more than 15%, meaning that, despite the impressive success of joint replacement surgery, a significant number of arthroplasties fail. It is becoming more common for young, active individuals to receive joint replacement surgery to improve their quality of life. This, combined with increasing life expectancy, and the known higher rate of failure of joint replacements in younger patients, means that the morbidity of a failed replacement, and the mobidity and associated mortality of revision surgery, will become an increasingly important health issue, with a major impact upon health budgets. The overwhelming majority of hip and knee prostheses have metal or ceramic on polyethylene bearing surfaces. It is now apparent that most implants fail due to bone loss around them leading to loosening, and evidence is accumulating that polyethylene wear particles are a major contributing factor to this process. It is therefore vital that we obtain better understanding of the causes of implant failure in order to extend the life of these implants and this project is designed to do so.Read moreRead less
Determination Of Irradiation Dose Efficacy For Use In Impaction Grafting At Revision Joint Replacement
Funder
National Health and Medical Research Council
Funding Amount
$411,517.00
Summary
Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence ....Primary hip replacement is a successful intervention for hip disease, but 10-15% of hip prostheses fail and require revision surgery within 10-15 years. At the time of revision, significant bone loss around the failed prosthesis is not uncommon. A bone reconstruction procedure, called impaction grafting, where donor bone is minced and placed in the areas of deficient bone before implanting the new prosthesis, has shown to give good results at more than ten years in some centres. A high incidence of early complications of this procedure have included loss of fixation within the bone. Fracture of the bone around prostheses has also reported in some centres. These events require more surgery, putting the patient at higher risk greater complications and longer rehabilitations. Recent improvements in surgical technique and donor bone preparation have improved results. A current debate questions whether the dose of irradiation can be reduced from 25 kGy, while maintaining sterility of allografts. The risk of bacterial contamination in allografts is low, and irradiation reduces the mechanical strength of the graft, contributing to complications when irradiated bone is used. The benefits of decontaminating the bone may be outweighed by the higher risk for failure due to poor bone quality and resulting prosthesis instability. We will use ISO standards to test the validity of radiation dose for sterilising bone ex vivo. In the absence of controlled human studies, our aim is also to compare the results of impaction grafting with non-irradiated bone versus bone irradiated at current doses used by Australian bone banks, and lower doses indicated by ex vivo testing. We will use a large animal model of revision hip replacement, with precise measures of prosthesis stability. The results of this study will guide clinical decisions regarding the efficacy of current bone graft preparation procedures and the use of irradiated bone in human hip replacement surgery.Read moreRead less
A novel approach to controlling boundary-layer separation. This project will involve fundamental research into the control of the fluid dynamical phenomena of boundary-layer separation and transition to turbulence. The project will be built upon a firm foundation of mathematical modelling of the complex behaviour of fluid flows that are near the onset of flow separation or turbulence. The project will produce results that will permit the development of control strategies that can be implemented ....A novel approach to controlling boundary-layer separation. This project will involve fundamental research into the control of the fluid dynamical phenomena of boundary-layer separation and transition to turbulence. The project will be built upon a firm foundation of mathematical modelling of the complex behaviour of fluid flows that are near the onset of flow separation or turbulence. The project will produce results that will permit the development of control strategies that can be implemented in a wide variety of important technological applications, such as drag reduction in the aerospace and ship industries as well as the control of stall (or loss of lift) in modern aircraft.Read moreRead less
Modelling the capillary entrapment phenomena and integrity of geological reservoirs for clean energy, water and waste management technologies. This project will improve our understanding of non-linear flow and fracture phenomena in porous media which is prerequisite for the development of new emerging technologies targeting the reduction of the greenhouse gas emission and development of effective waste and water management solutions including coal gasification, in-situ storage of natural and non ....Modelling the capillary entrapment phenomena and integrity of geological reservoirs for clean energy, water and waste management technologies. This project will improve our understanding of non-linear flow and fracture phenomena in porous media which is prerequisite for the development of new emerging technologies targeting the reduction of the greenhouse gas emission and development of effective waste and water management solutions including coal gasification, in-situ storage of natural and non-hydrocarbon gases, underground disposal of hazardous wastes and vadose zone remediation. The project will result in a dramatic improvement of the predictive tools for traditional ground water management, irrigation and petroleum recovery applications. It has the strength to place Australia in the forefront of these technologies. Read moreRead less
Robust fluid mixing through topological chaos. The Australian chemicals and plastics industry has an annual turnover of over $20 billion and employs over 77,000 people; fluid mixing is fundamental to this industry, yet the industry is recognised as underinvesting in research and development in this essential area. Furthermore, frontier technologies such as biotechnology and the next generation of smart materials also crucially rely on fluid mixing. This project aims to evaluate a new paradigm ( ....Robust fluid mixing through topological chaos. The Australian chemicals and plastics industry has an annual turnover of over $20 billion and employs over 77,000 people; fluid mixing is fundamental to this industry, yet the industry is recognised as underinvesting in research and development in this essential area. Furthermore, frontier technologies such as biotechnology and the next generation of smart materials also crucially rely on fluid mixing. This project aims to evaluate a new paradigm (topological chaos) for the design of mixers, to provide better and more robust mixers that work from microscopic to industrial scales.Read moreRead less
Damage Tolerance Approach in Designing and Maintaining Truck Trailers. This project aims to develop a damage tolerance approach in designing and maintaining truck trailers. Combined with field test and computational simulation, machine learning will be used to generate loading spectrums. Following the damage tolerance philosophy, a mature approach in aerospace industry, the fatigue crack growth and the fatigue life will be predicted. In addition, structural optimisation will be applied in traile ....Damage Tolerance Approach in Designing and Maintaining Truck Trailers. This project aims to develop a damage tolerance approach in designing and maintaining truck trailers. Combined with field test and computational simulation, machine learning will be used to generate loading spectrums. Following the damage tolerance philosophy, a mature approach in aerospace industry, the fatigue crack growth and the fatigue life will be predicted. In addition, structural optimisation will be applied in trailer design. This project expects to revolutionize the design and maintenance practices in Australian truck trailer industry. It should provide significant benefits, such as prolonging the life cycle of truck trailers, reducing the tare weight and increasing operating profit, to both trailer producers and users.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101571
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Assimilation of ocean wave interactions with sea ice into climate models. Contemporary climate models do not accurately portray ocean or atmosphere interactions where the open ocean meets the expanses of floating sea ice within the polar regions, as they lack a component to determine the size of ice floes. This project will tackle the omission directly, developing from modelling advances made in recent years.