Endothelial Dysfunction As A Therapeutic Target In Severe Malaria
Funder
National Health and Medical Research Council
Funding Amount
$842,329.00
Summary
Even with very best drugs to kill malaria parasites, over 15% of patients with severe malaria still die. Their blood vessels are clogged up by malaria parasites. We have shown that the cells lining their blood vessels can't make enough nitric oxide to keep them non-sticky and allow blood through. We want to test whether giving arginine can 1) increase nitric oxide, 2) open up the clogged blood vessels and 3) dampen down other processes that clog up blood vessels in severe malaria.
A Randomised Controlled Trial Of L-arginine And-or Vitamin D To Improve Outcomes In Pulmonary Tuberculosis
Funder
National Health and Medical Research Council
Funding Amount
$942,297.00
Summary
Two nutrients, arginine and vitamin D, are used by defence cells in our lungs to kill the tuberculosis bacteria. We will test whether giving arginine and-or vitamin D to people with TB (in addition to their usual TB medications) will help them recover faster and cause less long-term lung damage. We will also check whether these nutrients make them less infectious to other people.