The Role Of Cell Death Pathways In Inflammation And Pathogen Infection
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
Cell death and inflammation are essential for protection against pathogen infection but can also cause human diseases. Inflammation caused by the IL-1? protein has been implicated in diseases such as type II diabetes, arthritis and cancer. This project aims to elucidate how IL-1? protein activity is regulated at the molecular level. It also seeks to understand how the pathogen responsible for Legionnaires’ disease manipulates cell death to allow for successful invasion of the human host.