Inflammatory lipids are involved in neurotrauma. They are key players in regulating the brain, spinal cord and immune responses to injury and thus in modulating the outcome of central nervous system (CNS) damage. We will investigate how bioactive inflammatory lipids, released during trauma, modulate neural response to injury and regeneration, by assessing their roles on central nervous system responses to injury.
The Role Of CD1-restricted T Cells In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
The human immune system requires T cells for survival. Specialised populations of T cells exist that patrol the body and target unwanted lipid molecules expressed by bacteria or by cells that have become abnormal or cancerous. I will identify these T cells in human blood and skin and determine their role in protection against disease. I will explore the types of lipids molecules recognised by these T cells and use this information to help prevent human diseases.