The human immune system comprises many different types of cells that can detect foreign molecules. My research will lead the way to understanding some of the most abundant, yet least well understood, cells within this system, collectively known as 'unconventional T cells'. This knowledge is essential to optimally and efficiently manipulate the immune system in health and disease.
Antigen Recognition By CD1a-restricted T Cells In The Human Immune System
Funder
National Health and Medical Research Council
Funding Amount
$615,520.00
Summary
Human immunity requires protective T cells that target foreign molecules for removal. Even though substantial populations of T cells exist that recognise lipid molecules, little is known about their basic biology. We will identify and characterise lipid reactive human T cells and examine their response to foreign or self-lipids expressed by infectious organisms and host cells. This work will have important implications in understanding lipid reactive T cells in health and disease.
The Role Of CD1-restricted T Cells In Health And Disease
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
The human immune system requires T cells for survival. Specialised populations of T cells exist that patrol the body and target unwanted lipid molecules expressed by bacteria or by cells that have become abnormal or cancerous. I will identify these T cells in human blood and skin and determine their role in protection against disease. I will explore the types of lipids molecules recognised by these T cells and use this information to help prevent human diseases.
Lipid Antigen Recognition By Diverse CD1-restricted T Cells
Funder
National Health and Medical Research Council
Funding Amount
$312,625.00
Summary
Natural Killer T (NKT) cells are a specialized T cell lineage that form a key part of the adaptive immune response required for protection against infection, allergy, cancer and autoimmune diseases. Different types of NKT cells exist, expressing distinct T cell receptors that recognize a large array of lipid antigens presented during disease conditions. Understanding the mechanisms involved in lipid recognition is crucial in deciphering how NKT cells can be manipulated for desired immune respons ....Natural Killer T (NKT) cells are a specialized T cell lineage that form a key part of the adaptive immune response required for protection against infection, allergy, cancer and autoimmune diseases. Different types of NKT cells exist, expressing distinct T cell receptors that recognize a large array of lipid antigens presented during disease conditions. Understanding the mechanisms involved in lipid recognition is crucial in deciphering how NKT cells can be manipulated for desired immune responses.Read moreRead less