Monitoring Of Leucocyte Cytokine-chemokines To Improve Morbidity And Rejection Rates In Lung Transplant Patients
Funder
National Health and Medical Research Council
Funding Amount
$373,973.00
Summary
Lung transplantation has become established therapy for many serious lung diseases. The early success rate is now very good, but at five years after transplant the survival rate is only around 60%. This problem is largely due to chronic graft failue as a result of chronic rejection or bronchiolitis obliterans syndrome. This project will specifically investigate the causes of BOS and thereby provide new information on how we may best treat this problem. An improvement in this area is critical.
Cross-reactive Anti-viral T Cells Mediate Allograft Rejection In Lung Transplantation.
Funder
National Health and Medical Research Council
Funding Amount
$379,563.00
Summary
In solid organ transplantation chronic viral infections can play a major role in causing graft dysfunction and-or loss. This study investigates the role of a specific population of immunological cells. These specific anti-viral immune cells are key controllers of viral infections and have also been implicated in mediating the destruction and-or rejection of a transplanted graft.
Protecting The Endothelial Glycocalyx To Improve Transplant Rates And Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$725,180.00
Summary
A tiny, previously overlooked, structure called the endothelial glycocalyx (EG) is now known to ‘waterproof’ blood vessels. This grant extends our exciting preliminary data in the field of lung transplantation, where we have shown that EG loss is the main cause of a poorly functioning organ, to develop new tests of lung and kidney function, as well as treatments to resuscitate marginal organs outside the body, so improving access to and the safety of transplantation.
Activin A And Follistatin Are Potential Key Regulators Of Organ Transplant Dysfunction And Graft Survival.
Funder
National Health and Medical Research Council
Funding Amount
$535,579.00
Summary
The grant examines novel key regulators in organ transplantation. It examines molecules that are released during transplant surgery and on the return of blood flow to the organ which can cause inflammation and scarring. The release is increased by heparin, an anticoagulant used in organ preparation. Alternative anticoagulants and blockers of the regulators released will be tested to prevent the damage to the transplant, potentially improving both the short and long term graft survival and functi ....The grant examines novel key regulators in organ transplantation. It examines molecules that are released during transplant surgery and on the return of blood flow to the organ which can cause inflammation and scarring. The release is increased by heparin, an anticoagulant used in organ preparation. Alternative anticoagulants and blockers of the regulators released will be tested to prevent the damage to the transplant, potentially improving both the short and long term graft survival and function.Read moreRead less
HLA-E, a protein expressed by all cells regulates both innate and adaptive immune responses by binding to receptors found on white blood cells. This project will examine different ways that lymphocytes recognise this protein and its role in infection and transplantation.
The Menstrual Cycle, Menopause And Gender Specific Health Needs Of Women With Complex Medical And Psychiatric Conditions.
Funder
National Health and Medical Research Council
Funding Amount
$149,982.00
Summary
The great advances in medical science mean that women are living longer, sometimes with very complex conditions.The aim of this study is to determine how common women’s health issues are in women who have had a lung or bone marrow transplant and in women with severe mental illness. The study will involve face to face interview with women and then a survey of a larger number of women. The study will help improve the care and quality of life of women who already face significant health challenges.