Mosquito-borne alphaviruses such as Ross River and chikungunya viruses cause widespread epidemics and exert extreme pressure on the public health systems of affected regions. Alphaviruses spreads to joints and triggers a severe disease in those affected. There are no effective treatments or vaccines. The project will investigate virus-host interaction at the bite site. The outcome will be new knowledge to treat infection at the mosquito bite site to prevent joint disease.
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
What makes for successful numeracy education in remote Indigenous contexts: an ethnographic case study approach. There are many successful teachers and schools who have enabled remote Indigenous learners to engage with, and learn, school mathematics. But what do they do? How do they do it? This project investigates and documents successful practices in 32 schools located in remote communities. The project includes the many aspects of teaching practice.
Social and geographical location and its impact on mathematics teaching and learning. Too many students from poor urban backgrounds or from rural communities are at risk of underperforming in school mathematics. This project identifies the critical factors that contribute to this failure and seeks to develop improved practices to enable greater access to school mathematics.
Developmental engineering education in the primary school. Primary school students will learn about engineers and how engineering shapes our society. Students will develop important design processes in solving authentic, engineering-based problems. Their learning in the increasingly important science, technology, engineering, and mathematics (STEM) area will be enhanced, providing a foundation for addressing the increasing skills shortage in engineering.
Bringing back Australia's lost woodland biodiversity: towards strategic multi-species reintroductions. Australia has the highest rate of mammal extinction of any continent on the planet. This has reduced biodiversity and compromised many important ecological processes. What is the best way to re-build depauperate mammal communities with multi-species reintroductions? What effects do multi-species reintroductions have on recipient ecosystems? This project aims to explore these questions by reintr ....Bringing back Australia's lost woodland biodiversity: towards strategic multi-species reintroductions. Australia has the highest rate of mammal extinction of any continent on the planet. This has reduced biodiversity and compromised many important ecological processes. What is the best way to re-build depauperate mammal communities with multi-species reintroductions? What effects do multi-species reintroductions have on recipient ecosystems? This project aims to explore these questions by reintroducing three mammal species to a critically endangered temperate woodland: a carnivore (the eastern quoll), an insectivore (yellow-footed antechinus), and a herbivore (the eastern chestnut mouse). Results from this sequenced multi-species reintroduction experiment will have broad applicability to ecosystem restoration in Australia and overseas.Read moreRead less
Have we already lost the Australian lungfish? This project aims to use radiocarbon ageing, conservation genetics and modelling to identify threats to the long-term survival of the Australian lungfish, the world's oldest living vertebrate. This project will provide managers with a powerful tool to prioritise management interventions to ensure the conservation of the species and to pull it back from extinction.
Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the h ....Reducing health disparities for culturally and linguistically diverse peoples. This project aims to develop a greater understanding of migrants and the factors that predict poor health outcomes related to blood-borne viruses and sexually transmitted infections. The delayed access by migrants to healthcare from culturally and linguistically diverse backgrounds results in late diagnosis, low treatment uptake, and poorer health outcomes, with enhanced risk of infection and increased burden on the health system. The data collected in this project will assist in developing health services to meet these needs.Read moreRead less
Reintroduction of ecosystem engineers as a woodland restoration tool. Can we help restore woodlands by reintroducing extinct native mammals? Through a strategic partnership combining innovative research and conservation action, this project will investigate how returning extinct 'ecosystem engineers' could be used as a tool for restoring healthy temperate woodland ecosystems.