Solving Delivery Of Gene Therapy For Control Of Human Immunodeficiency Virus Infection
Funder
National Health and Medical Research Council
Funding Amount
$765,439.00
Summary
Antiretroviral therapy free control of Human Immunodeficiency Virus (HIV) infection requires control of the viral reservoir. We have a unique approach, aimed at enforcing HIV latency by targeting highly conserved regions in the viral promoter. These constructs completely silence viral transcription for long periods of time. We intend to develop & assess vectors that are specifically targeted to the reservoir and which can enforce viral latency despite immune activation or viral variation.
HIV-1 Transcriptional Gene Silencing By Promoter Targeted Si/shRNAs: Uncovering Mechanisms, Optimising Delivery Systems, Assessing In Vivo Efficacy.
Funder
National Health and Medical Research Council
Funding Amount
$641,789.00
Summary
Current therapy for HIV is effective but must be taken for life. If therapy is stopped the virus comes back immediately from reservoirs not affected by current drugs. These fluctuating levels of virus are associated with increased illness and death. We are exploring a method of inducing prolonged viral latency using short double stranded RNA molecules. We propose to understand the mechanism of action of these possible therapeutics and to develop these constructs towards use in clinical trials.
Redirecting T-cells For Immunotherapy Of Leukaemia And Lymphoma By The Expression Of A CD19-specific Chimeric Antigen Receptor Using The PiggyBac Transposon Gene Modification System
Funder
National Health and Medical Research Council
Funding Amount
$374,876.00
Summary
Most lymphomas respond to therapy but then relapse. Immune cells can attack and kill virus related lymphomas. However, most lymphomas are NOT virus related. We will create immune cells targeting these virus negative lymphomas by inserting artificial receptors into the immune cells. These receptors attach to the lymphoma and activate the immune cells. The immune cells will home to the lymphoma, kill lymphoma cells and persist in the body for many years, preventing lymphoma relapse.
On the mechanism of boiling instability in microchannels. This project will enable designers to create highly efficient miniaturised devices based on the boiling of fluids such as water or organics. These devices include micro-power generation systems, coolers for computer chips and solar collectors, and micro-chemical process systems. Such devices provide environmental, safety and economic benefits.
Heat Transfer Characteristics of Biological Tissues with Nanoparticles. Heat transfer of laser-irradiated nanoparticles in biological tissues requires a basic knowledge of the unique strong resonance absorption properties and a fundamental understanding of the thermal and chemical conversions as a consequence of these heated nanoparticles. This project aims to investigate the extent of the non-equilibrium heating effects of heated nanoparticles on the destruction of biological tissues. Comprehen ....Heat Transfer Characteristics of Biological Tissues with Nanoparticles. Heat transfer of laser-irradiated nanoparticles in biological tissues requires a basic knowledge of the unique strong resonance absorption properties and a fundamental understanding of the thermal and chemical conversions as a consequence of these heated nanoparticles. This project aims to investigate the extent of the non-equilibrium heating effects of heated nanoparticles on the destruction of biological tissues. Comprehensive experimental studies and computational modelling to be performed are expected to significantly enhance the understanding of laser-induced heating phenomena of embedded nanoparticles in biological tissues and the prediction of the level of destruction that can be experienced by these heated nanoparticles.Read moreRead less
Design and Optimisation of Novel Enthalpy Heat Exchangers. This project deals with the thermal design and optimisation of a novel type of latent energy heat exchanger. This new heat exchanger overcomes the practical implementation problems of previous latent energy heat exchangers such as heat-wheels. The main application of this innovative heat exchanger will be to improve the capacity and efficiency of air conditioning systems. As the new heat exchanger is very compact it will be ideally sui ....Design and Optimisation of Novel Enthalpy Heat Exchangers. This project deals with the thermal design and optimisation of a novel type of latent energy heat exchanger. This new heat exchanger overcomes the practical implementation problems of previous latent energy heat exchangers such as heat-wheels. The main application of this innovative heat exchanger will be to improve the capacity and efficiency of air conditioning systems. As the new heat exchanger is very compact it will be ideally suited for integration with air conditioning coils. Existing latent heat wheels are very bulky and are difficult to integrate into standard air conditioner installations.Read moreRead less
Design of high performance heat sink composites. Heat sink composites are advanced materials that have the very substantial but widely untapped potential to reduce Society's energy consumption by means of utilizing waste energy or through energy-efficient temperature control. This Project uses computational analysis and parallel experimentation to design optimum heat-sink composites for highly energy-efficient temperature control of chemical batteries or electronic components as well as the mean ....Design of high performance heat sink composites. Heat sink composites are advanced materials that have the very substantial but widely untapped potential to reduce Society's energy consumption by means of utilizing waste energy or through energy-efficient temperature control. This Project uses computational analysis and parallel experimentation to design optimum heat-sink composites for highly energy-efficient temperature control of chemical batteries or electronic components as well as the means for the efficient heating/cooling of buildings. The outcomes of the project will lay the scientific foundation for the industrial scale development of advanced heat sinks that will lower energy costs and decrease climate changing emissions. This represents a new market for Australian industry.Read moreRead less
Analysis, simulation, fabrication and characterization of reliable, robust and scalable compact cooling elements based on semiconductor nanostructures. Modern electronic, microelectronic and optoelectronic devices generally work better when they are cooler. We aim to develop a semiconductor nanostructure cooling element which directly integrates into existing devices. The solid-state cooling element will be reliable, robust, scalable and operate in any orientation. The basis of operation is ....Analysis, simulation, fabrication and characterization of reliable, robust and scalable compact cooling elements based on semiconductor nanostructures. Modern electronic, microelectronic and optoelectronic devices generally work better when they are cooler. We aim to develop a semiconductor nanostructure cooling element which directly integrates into existing devices. The solid-state cooling element will be reliable, robust, scalable and operate in any orientation. The basis of operation is thermionic emission - electrons are the working fluid. Our project combines (1) analysis and simulation, (2) fabrication of nanostructures and (3) experimental test-benching using optical and electrical methods. The outcome of this research has the potential to revolutionize cooling of modern electronic and photonic systems, from computer motherboards to mobile phones.Read moreRead less
Novel methods for enhancing room temperature figure of merit of thermoelectric/thermionic materials for refrigeration applications. With global warming and an increased awareness of climate change, devices such as thermoelectric modules can be part of the solution, particularly if their relative power and efficiency can be increased. The aim of this project is to bring together theoreticians, experimentalists, materials scientists, and industrial partners with complementary expertise to develop ....Novel methods for enhancing room temperature figure of merit of thermoelectric/thermionic materials for refrigeration applications. With global warming and an increased awareness of climate change, devices such as thermoelectric modules can be part of the solution, particularly if their relative power and efficiency can be increased. The aim of this project is to bring together theoreticians, experimentalists, materials scientists, and industrial partners with complementary expertise to develop new techniques and methods for fabricating novel thermoelectric/thermionic materials with high figure of merit, ZT, for solid state refrigeration applications. The success of the project will lead to a 3 to 5 fold increase in the market share of thermoelectric cooler and will have a significant impact on the Australian economy and reduce greenhouse emissions and global warming. Read moreRead less
A Fundamental Study on Redox Behaviour of Oxygen Carriers in Chemical Looping Combustion. Our goal here is to acquire fundamental knowledge about the redox behaviour of metal oxide oxygen carriers which, arguably, underpins the feasibility of the Chemical Looping Combustion (CLC) concept. Although the proposed work is fundamental and will contribute to the advancement of knowledge, the results will have immediate practical applications in power generation industry at both national and internatio ....A Fundamental Study on Redox Behaviour of Oxygen Carriers in Chemical Looping Combustion. Our goal here is to acquire fundamental knowledge about the redox behaviour of metal oxide oxygen carriers which, arguably, underpins the feasibility of the Chemical Looping Combustion (CLC) concept. Although the proposed work is fundamental and will contribute to the advancement of knowledge, the results will have immediate practical applications in power generation industry at both national and international levels. This should significantly contribute to the Australian Government's efforts in producing world class solutions for abatement of greenhouse emissions (Research Priority 1: An Environmentally Sustainable Australia, Priority Goal 1.4 - Reducing and capturing emissions in transport and energy generation).Read moreRead less