Genetic code expansion of a eukaryotic in vitro translation system. The genetic code programs biosynthesis of polypeptides with efficiency vastly superior to chemical engineering. As the chemical diversity of natural amino acids in proteins is limited, finding ways to include “unnatural” amino acids can supercharge biology with a range of new protein activities. While the genetic code can be expanded to make space for unnatural amino acids, the rarity of free codons and reliance on prokaryotic ....Genetic code expansion of a eukaryotic in vitro translation system. The genetic code programs biosynthesis of polypeptides with efficiency vastly superior to chemical engineering. As the chemical diversity of natural amino acids in proteins is limited, finding ways to include “unnatural” amino acids can supercharge biology with a range of new protein activities. While the genetic code can be expanded to make space for unnatural amino acids, the rarity of free codons and reliance on prokaryotic organisms limit the applicability of this approach. We will develop a new higher-organism cell-free protein production system that can incorporate multiple unnatural amino acids into defined points of proteins. This, enabling and broadly applicable technology, will be tested by constructing opioid biosensors.Read moreRead less
Making plants better, making Australia better? A history of genetic modification science, policy, and community attitudes in Australia. This project will document and analyse the history of the development of genetic modification (GM) science and policy, and the associated community attitudes and activism efforts in Australia over the last 40 years, with a focus on the development of GM for food and agricultural purposes. In addition to producing a rich historical narrative of critical scientifi ....Making plants better, making Australia better? A history of genetic modification science, policy, and community attitudes in Australia. This project will document and analyse the history of the development of genetic modification (GM) science and policy, and the associated community attitudes and activism efforts in Australia over the last 40 years, with a focus on the development of GM for food and agricultural purposes. In addition to producing a rich historical narrative of critical scientific and policy developments associated with GM in Australia. This project will explore how Australians respond to new scientific ideas and technologies, and use this evidence as the basis for a case study of prospects for future community involvement in the development of science policy particularly in association with emerging technologies.Read moreRead less
Keeping Kinship in Mind. This project aims to contribute to a better understanding of the study of kinship by drawing on recent research from the philosophy of mind and the philosophy of science. It will incorporate this understanding into a more general international, collaborative network in the philosophy of anthropology. Kinship has been central to anthropology as a discipline, with disagreement over the relationships between biological and cultural dimensions to kinship structuring much o ....Keeping Kinship in Mind. This project aims to contribute to a better understanding of the study of kinship by drawing on recent research from the philosophy of mind and the philosophy of science. It will incorporate this understanding into a more general international, collaborative network in the philosophy of anthropology. Kinship has been central to anthropology as a discipline, with disagreement over the relationships between biological and cultural dimensions to kinship structuring much of that history. Keeping Kinship in Mind will extend into the philosophy of the social sciences the productive interactions between philosophers and scientists that are an internationally recognized research strength of Australian philosophy of science. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE210101440
Funder
Australian Research Council
Funding Amount
$431,015.00
Summary
Using big data to untangle ecological cascades in tropical forests. This project aims to develop a suite of innovative analysis techniques to study wildlife communities with remarkable resolution. This project expects to generate new knowledge in the fields of ecology and conservation biology by leveraging the unprecedented quantity and quality of data captured through a large network of camera traps in Australian and Southeast Asian forests. Expected outcomes include developing novel approaches ....Using big data to untangle ecological cascades in tropical forests. This project aims to develop a suite of innovative analysis techniques to study wildlife communities with remarkable resolution. This project expects to generate new knowledge in the fields of ecology and conservation biology by leveraging the unprecedented quantity and quality of data captured through a large network of camera traps in Australian and Southeast Asian forests. Expected outcomes include developing novel approaches to analysing wildlife data (meta-structural equation modelling) and delivering management guidance to Australian land-owning agencies that may vastly cut costs by identifying efficient interventions and improve conservation outcomes. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100784
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Improving cereal grain quality using epigenetic regulators. The project aims to determine the epigenetic regulatory mechanisms that control cereal grain quality and yield under water-deficit and heat stress. The project will use next-generation sequencing to identify key epigenetic regulators and their functional target genes, which confer superior grain quality to elite genotypes under adverse environments. Project outcomes will benefit cereal breeding by providing more-tailored screening stra ....Improving cereal grain quality using epigenetic regulators. The project aims to determine the epigenetic regulatory mechanisms that control cereal grain quality and yield under water-deficit and heat stress. The project will use next-generation sequencing to identify key epigenetic regulators and their functional target genes, which confer superior grain quality to elite genotypes under adverse environments. Project outcomes will benefit cereal breeding by providing more-tailored screening strategies and superior parental germplasm with enhanced quality and yield. The development of nutritionally improved crops will benefit the Australian cereal industry and export opportunities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100121
Funder
Australian Research Council
Funding Amount
$423,534.00
Summary
Why do some declining species persist while others go extinct? Global change is driving thousands of species towards extinction. Legislation requires the protection of biodiversity, but current scientific understanding of species declines limits effective action. By taking a new approach to studying species declines, this integrative research aims to identify why some species persist, while others decline. This project is expected to improve understanding of species vulnerability to extinction, ....Why do some declining species persist while others go extinct? Global change is driving thousands of species towards extinction. Legislation requires the protection of biodiversity, but current scientific understanding of species declines limits effective action. By taking a new approach to studying species declines, this integrative research aims to identify why some species persist, while others decline. This project is expected to improve understanding of species vulnerability to extinction, and the conditions which allow species to coexist with threats. Anticipated benefits include advancing ecological theory, improving conservation planning, and increasing the efficiency and effectiveness of policy and management to prevent species extinctions.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100155
Funder
Australian Research Council
Funding Amount
$909,079.00
Summary
Advancing 4D fluorescence microscopy within Australia. This multi-institutional proposal aims to establish a state-of-the-art Lightsheet microscope facility in South Australia with enhanced analysis infrastructure and a national user support network. Expectations are, this will transform researcher outcomes for multiple disciplines by facilitating high-resolution four-dimensional interrogation of novel biological processes. Significant benefits will include the ability to image deep within livin ....Advancing 4D fluorescence microscopy within Australia. This multi-institutional proposal aims to establish a state-of-the-art Lightsheet microscope facility in South Australia with enhanced analysis infrastructure and a national user support network. Expectations are, this will transform researcher outcomes for multiple disciplines by facilitating high-resolution four-dimensional interrogation of novel biological processes. Significant benefits will include the ability to image deep within living tissue over long time-scales without inducing phytotoxicity to produce high-impact fundamental and translatable outcomes, the development of novel probes and methodologies, new cross-disciplinary collaborations, and new and unique funding, student training and public engagement opportunities.Read moreRead less
Towards genome methylation based crop improvement. Deoxyribonucleic acid (DNA) methylation is a form of genetic control that regulates crop performance and the crop's response to the environment. Improving understanding of the inheritance of methylation in relation to crop performance will provide the basis for methylation based breeding for climate resilient crops.
Developing strong restorer-of-fertility genes for hybrid wheat breeding. Hybrid wheat varieties yield 10-15% more than conventional lines but a cost-effective system to produce hybrid seeds on a commercial scale is missing. This project aims to deliver such a system for use in hybrid wheat breeding programmes. The outcome will be ultimately higher wheat yield gains in Australia and worldwide. Higher and more stable yields will contribute to higher food security for the growing human population.
Genetic rescue, restoration and adaptation. This project aims to evaluate a promising but rarely used method of population recovery by genetically rescuing populations of two threatened Australian mammals: the mountain pygmy possum and the eastern barred bandicoot. Despite our best efforts to curb biodiversity loss, extinction rates are increasing and Australia is expected to lose a substantial proportion of its unique endemic fauna over the next 20–50 years. By tracking the phenotypic and under ....Genetic rescue, restoration and adaptation. This project aims to evaluate a promising but rarely used method of population recovery by genetically rescuing populations of two threatened Australian mammals: the mountain pygmy possum and the eastern barred bandicoot. Despite our best efforts to curb biodiversity loss, extinction rates are increasing and Australia is expected to lose a substantial proportion of its unique endemic fauna over the next 20–50 years. By tracking the phenotypic and underlying genomic changes that occur when a population undergoes a genetic rescue, the project aims to create data of interest to conservation biology.Read moreRead less