Identifying Rare Genetic Variants Conferring Susceptibility To Multiple Sclerosis
Funder
National Health and Medical Research Council
Funding Amount
$293,898.00
Summary
Recently there has been success in identifying common genetic variants that confer susceptibility to multiple sclerosis. The variants that have been discovered so far have modest effects on risk of disease, and only explain a small proportion of familial aggregation of disease. In this study we aim to identify rarer genetic variants that have stronger effects on risk of disease, using new statistical methods and new methods to sequence very large amounts of DNA.
Energy Transitions, Air Pollution And Health In Australia
Funder
National Health and Medical Research Council
Funding Amount
$2,491,229.00
Summary
Emissions from burning biomass (including fossil fuels) are major features of our environment and are the 4th leading global risk factor for premature death. As countries shift their patterns of energy use in response to global warming, new challenges are emerging. Understanding this is crucial to our ability to maintain health and stability in uncertain times. This CRE will examine the health consequences of (1) fossil fuel combustion, (2) landscape fires and (3) alternatives to fossil fuels.
Self-assembled phases as effective and selective materials for analysis. This project aims to develop a suite of self-assembled amphiphilic molecules to form distinctive materials for analytical chemistry. The cost-effective, easy to prepare, selective and environmentally benign materials will be for non-volatile bioactive and chiral molecular targets that are commonly encountered every day or are difficult to study. The project will open a new research area and will further uplift the internati ....Self-assembled phases as effective and selective materials for analysis. This project aims to develop a suite of self-assembled amphiphilic molecules to form distinctive materials for analytical chemistry. The cost-effective, easy to prepare, selective and environmentally benign materials will be for non-volatile bioactive and chiral molecular targets that are commonly encountered every day or are difficult to study. The project will open a new research area and will further uplift the international standing of Australia in the field. The project will provide a high level of training and expertise for Australia-based chemists.Read moreRead less
Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100035
Funder
Australian Research Council
Funding Amount
$4,958,927.00
Summary
ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, ....ARC Training Centre for Hyphenated Analytical Separation Technologies . The toughest analytical science challenges typically require advanced analytical technologies to acquire the desired solutions. In the field of separation science this inevitably involves hyphenated separation technologies, specifically the combination of chromatography and mass spectrometry. Advancing this technology to its full capability requires the collaborative strength of academic, industry and end-user partnerships, providing the materials and inspiration for young researchers to apply novel hyphenated methods to complex environmental and industrial systems. This Centre will deliver fundamental developments in hyphenated technologies, new analytical capability, and applied outcomes across multiple end-user groups and interests. Read moreRead less
Solid-state light sources for bio-imaging and microfluidics. Solid state light sources are the light sources of the 21st century. This project will allow us to find new ways of bioimaging in living organisms applicable to diagnosing disease, and for microfluidic chip based portable instruments for on-site and point-of-care analysis in medical diagnostics, environmental monitoring, and manufacturing processes.
Enhancing Selectivity and Detection in Miniaturised Analytical Separation Systems. Miniaturisation-compatible stationary phases and detection techniques will be developed for microseparation techniques of capillary electrochromatography and chip-based separation systems, and their analytical applications will be investigated. Replaceable stationary phases (RSP) of chromatographic particles suspended in reversible gels will be created by delivering a liquid RSP to the column followed by in situ ....Enhancing Selectivity and Detection in Miniaturised Analytical Separation Systems. Miniaturisation-compatible stationary phases and detection techniques will be developed for microseparation techniques of capillary electrochromatography and chip-based separation systems, and their analytical applications will be investigated. Replaceable stationary phases (RSP) of chromatographic particles suspended in reversible gels will be created by delivering a liquid RSP to the column followed by in situ immobilisation. This approach offers flexibility in optimising a number of parameters of the column and of its use for sample pre-treatment and preconcentration. Pulsed potentiometric detection will be developed for the abovementioned microseparation techniques, combining the advantages of pulsed amperometric techniques with the more universally responding potentiometric detection.Read moreRead less
Unraveling ocean mixing and air-sea forcing along the Indo-Pacific exchange. This project aims to collect unprecedented observations and develop high resolution model simulations to examine changes in the Indonesian Throughflow (ITF) north of Australia. This project expects to develop new knowledge of ocean-atmosphere interactions along the path of the ITF from the Pacific to the Indian Ocean, which are the powerhouse that drives changes in winds and rainfall around Australia and the entire Indo ....Unraveling ocean mixing and air-sea forcing along the Indo-Pacific exchange. This project aims to collect unprecedented observations and develop high resolution model simulations to examine changes in the Indonesian Throughflow (ITF) north of Australia. This project expects to develop new knowledge of ocean-atmosphere interactions along the path of the ITF from the Pacific to the Indian Ocean, which are the powerhouse that drives changes in winds and rainfall around Australia and the entire Indo-Pacific region. Expected outcomes include a 1000-fold increase in the observations of mixing in the Indonesian seas and new understanding of the ocean-atmosphere processes that control water property change along the ITF. This should lead to strong improvement in the skill of climate forecast models in the Australian region.Read moreRead less
A high speed, high fidelity 3D printer for fabricating microfluidic devices. This project aims to develop a novel 3D printer offering the highest resolution available and fastest printing speed for the single-step manufacturing of complex microfluidic devices. New resins developed to exploit the inert liquid interface layer printing approach will provide unprecedented capability to create micron sized channels interconnected in 3D space and fabricate Lab-on-a-Chip systems that cannot be generate ....A high speed, high fidelity 3D printer for fabricating microfluidic devices. This project aims to develop a novel 3D printer offering the highest resolution available and fastest printing speed for the single-step manufacturing of complex microfluidic devices. New resins developed to exploit the inert liquid interface layer printing approach will provide unprecedented capability to create micron sized channels interconnected in 3D space and fabricate Lab-on-a-Chip systems that cannot be generated by any current fabrication approach. This novel high speed, high fidelity 3D printer and the new resins to be developed are expected to lead to more effective manufacturing approaches for portable chemical devices and to promote complex chemical analysis into the knowledge immediacy culture of today.Read moreRead less
Novel approach to study mechanisms of Na+ transport in plants using Lab on a Chip technology. A Lab on a Chip for sodium ion measurements in plants is proposed, offering a long overdue solution to the lack of appropriate techniques to study the mechanisms of sodium iron uptake, transport and compartmentation. Sodium ion transport is a key determinant of salt tolerance, but a good understanding of its transport mechanisms is lacking since no appropriate measurement tools are available. Using the ....Novel approach to study mechanisms of Na+ transport in plants using Lab on a Chip technology. A Lab on a Chip for sodium ion measurements in plants is proposed, offering a long overdue solution to the lack of appropriate techniques to study the mechanisms of sodium iron uptake, transport and compartmentation. Sodium ion transport is a key determinant of salt tolerance, but a good understanding of its transport mechanisms is lacking since no appropriate measurement tools are available. Using the system proposed here, sodium ion is separated from interfering ions, allowing fast and selective measurements. A series of ground breaking studies towards sodium ion uptake, transport and compartmentation in plants will be conducted using this Lab on a Chip.Read moreRead less