The Essential Nuclear Transporter Importin 13; Key Role In Brain And Testis
Funder
National Health and Medical Research Council
Funding Amount
$613,124.00
Summary
Transport into and out of the nucleus, the control centre of cells, is critical for cell function in complex organisms such as mammals. The present proposal seeks to further understanding of a novel molecule mediating nuclear transport that has a novel inhibitory form in the testis, and important roles in the lung and nervous system. The results should help basic understanding of this molecule, and relate to disease conditions such as X-linked mental retardation and childhood asthma.
Investigating The Pathogenic Mechanisms Of Mutations In The ARX Homeobox Transcription Factor
Funder
National Health and Medical Research Council
Funding Amount
$596,222.00
Summary
Intellectual disability is frequent in the population with as many as 1 in every 50 people in the world directly affected. The cost to Australia of intellectual disability is estimated at $14 billion annually. ARX is one of the most frequent genes mutated in X chromosome linked intellectual disability. Our study will specifically address the functional impact of these mutations using cell models relevant to the brain to better understand the pathways and networks required for normal cognition.
Deaths In Young People Involved In The Youth Justice System: Towards Evidence-based Prevention
Funder
National Health and Medical Research Council
Funding Amount
$620,705.00
Summary
Young offenders have complex health needs and are at dramatically increased risk of preventable death due to drug overdose, suicide and injury. In order to inform effective prevention, a more detailed understanding of mortality in these young people is required. This project will examine all deaths in young offenders in Queensland from 1993 to 2015, identify targets for prevention, and recommend policy reforms and interventions that are supported by evidence and are culturally appropriate.
Evidence-based Recommendations For Interpregnancy Intervals In High-income Countries
Funder
National Health and Medical Research Council
Funding Amount
$423,305.00
Summary
This study will identify the optimal and harmful interpregnancy intervals for a range of maternal and child outcomes in three high-income countries. With a study population of more than 7.5 million births and a longitudinal study design that matches pregnancies to the same women, this study will inform new interpregnancy interval recommendations for high-income countries that will lead to a reduction in avoidable excess morbidities attributable to uninformed pregnancy planning.
Combating Escalating Harms Associated With Pharmaceutical Opioid Use
Funder
National Health and Medical Research Council
Funding Amount
$925,767.00
Summary
Increases in opioid use have been accompanied by increased opioid harms. But there is a lack of population-level evidence about drivers of long-term prescribed opioid use, dependence, overdose and other harms. Using linked data, we will fill these gaps using a cohort of all people in NSW prescribed opioids since 2002, linked to datasets containing information on health, social and health service utilisation, that will permit a comprehensive assessment of the risks of all prescribed opioids.
An Indigenous Australian Reference Genome: Indigenous Inclusion In The Benefits Of Genomic Medicine
Funder
National Health and Medical Research Council
Funding Amount
$1,428,508.00
Summary
This project will establish an Indigenous Australian reference genome (the NCIGrg) within the National Centre for Indigenous Genomics (NCIG) using advanced genome sequencing technologies and data analytics and evaluate its research and clinical utility. The NCIGrg will be cornerstone of future genomic research and its clinical application in Indigenous communities. It will underpin NCIG’s commitment to ensuring that Indigenous Australians are included in the benefits of genomic medicine.
A Computer-aided Diagnosis System For Gait Analysis
Funder
National Health and Medical Research Council
Funding Amount
$333,379.00
Summary
Gait analysis provides detailed information on how a patient walks to help orthopaedic surgeons decide on surgical treatments. However, gait analysis requires long and specific training and expertise in gait analysis is not widely available which restricts its benefits to the community. We will build the first computer-aided diagnosis system from renowned experts from The Royal Children’s Hospital Melbourne to assist clinicians interpreting gait analysis data nationally and internationally.
Temporal Trends In The Incidence, Site And Survival Of Metastatic Breast Cancer In Australia
Funder
National Health and Medical Research Council
Funding Amount
$190,494.00
Summary
There have been major advances in breast cancer treatment over the last decade. This project will use information collected from the NSW cancer registry and hospitals to report on changes in the type and risk of breast cancer spread and survival for women with a new diagnosis of breast cancer before and after new treatments introduced since 2005. This information is essential for doctors to provide women with up-to-date information; and for planning appropriate health services and research.
Measuring Low-value Health Care For Targeted Policy Action
Funder
National Health and Medical Research Council
Funding Amount
$806,176.00
Summary
It is claimed that up to 30% of (U.S.) health care represents waste, including the use of unsafe and ineffective health care practices. While many agree the problem exists, little empirical work has been completed to test this 30% figure, particularly in Australia. We will quantify the extent of, and variability in, waste across Australian health datasets (stand-alone and linked). This project will be the first of its kind in Australia and the largest and most comprehensive internationally.
Evaluation Of Enhanced Models Of Primary Care In The Management Of Stroke And Other Chronic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$556,184.00
Summary
Chronic diseases are the leading cause of death and disability in Australia. Since 1999, patients in Australia have been able to access a variety of comprehensive disease management programs subsidised through Medicare. We will use comprehensive linked data from survivors of stroke registered in the Australian Stroke Clinical Registry to provide the first robust evaluation of the effectiveness of these enhanced models of primary care in patients with chronic diseases using stroke as an example.