Women with diabetes in pregnancy and their babies are more likely to have health problems, e.g. preeclampsia, being born early, or admitted to neonatal intensive care unit. We know that lowering mum’s blood glucose to the levels found in women without diabetes is important but does not prevent problems completely. The purpose of these studies is to look at the other parts of metabolism that are different in women with diabetes e.g. blood fats, so we can understand if we should address them.
Effects Of RHDL On Diabetes In TRAIL-deficient Mice.
Funder
National Health and Medical Research Council
Funding Amount
$294,892.00
Summary
Diabetes is a chronic disease affecting 275 people daily in Australia. People with diabetes have a 2-4 fold greater risk for developing cardiovascular disease (CVD). TRAIL (TNF-related apoptosis-inducing ligand) can promote cell growth and death selectively. High density lipoproteins are shown to protect against diabetes and CVD. Understanding the mechanism(s) that mediate this process may lead to the design of therapeutic agents to reduce suffering of patients with diabetes and CVD.
Lipid Antigen Recognition By Diverse CD1-restricted T Cells
Funder
National Health and Medical Research Council
Funding Amount
$312,625.00
Summary
Natural Killer T (NKT) cells are a specialized T cell lineage that form a key part of the adaptive immune response required for protection against infection, allergy, cancer and autoimmune diseases. Different types of NKT cells exist, expressing distinct T cell receptors that recognize a large array of lipid antigens presented during disease conditions. Understanding the mechanisms involved in lipid recognition is crucial in deciphering how NKT cells can be manipulated for desired immune respons ....Natural Killer T (NKT) cells are a specialized T cell lineage that form a key part of the adaptive immune response required for protection against infection, allergy, cancer and autoimmune diseases. Different types of NKT cells exist, expressing distinct T cell receptors that recognize a large array of lipid antigens presented during disease conditions. Understanding the mechanisms involved in lipid recognition is crucial in deciphering how NKT cells can be manipulated for desired immune responses.Read moreRead less