Strain-level Characterisation And Visualisation Of The Mucosal Microbial Communities Associated With Inflammatory Bowel Disease (IBD) For The Development Of Novel Biotherapeutics
Funder
National Health and Medical Research Council
Funding Amount
$1,181,878.00
Summary
Australia has one of the highest incidence rates in the world of Inflammatory Bowel Disease (IBD), a debilitating inflammatory condition of the gastrointestinal tract. Cutting-edge molecular and visualisation technologies will be used to examine the role of the gut microbiome in IBD, and identify specific members of this community to be used as new therapies to suppress inflammation and improve outcomes for patients with IBD.
Assessing the determinants and consequences of safety climate in the maritime industry. This project will examine the predictors and outcomes of safety climate in the Australian maritime industry. Findings from this project will be used to improve safety policies, regulations and practices that aim to minimise the number of accidents and incidents in Australian waters.
A Structural Understanding Of Class B G Protein-coupled Receptor Function
Funder
National Health and Medical Research Council
Funding Amount
$1,289,570.00
Summary
G protein-coupled receptors (GPCRs) are the largest family of cell surface proteins that enable communication from external signals to the inside of cells of the body. Class B GPCRs are a therapeutically important subclass of these receptors and they play crucial roles in bone and energy homeostasis, cardiovascular control and immune response. This grant will uncover fundamental knowledge on how these receptors work, and will enhance future development of therapeutics.
Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms t ....Comparing properties of innate immune proteins of bats and humans. Supra-molecular protein complexes known as signalosomes drive our innate immune response by forming large signaling hubs capable of recruiting downstream effectors. This project aims to compare the properties and structure of human and bat signalosomes and discover the molecular origins of the “supra-immunity” of bats. In this context, the project expects to generate new knowledge concerning the fundamental molecular mechanisms that regulate the signalosomes. The intended outcome is to answer the long-standing question of control of speed and amplitude of innate immune response at the molecular level. Both locally and internationally, this new approach should provide benefits across structural biology, molecular evolution and biotechnology.Read moreRead less
Life in the Shipping Lane; The Cost of Increasing Disturbance to Whales. This project aims to quantify the increasing risk of ship strike to humpback whales in Moreton Bay, and predict the impact of chronic disturbance to nursing calves. The research builds on pilot findings identifying Moreton Bay as a resting area for migrating humpback whales. Using empirical and modelling approaches, this research responds directly to the Federal Government strategy for mitigating ship strike, which explicit ....Life in the Shipping Lane; The Cost of Increasing Disturbance to Whales. This project aims to quantify the increasing risk of ship strike to humpback whales in Moreton Bay, and predict the impact of chronic disturbance to nursing calves. The research builds on pilot findings identifying Moreton Bay as a resting area for migrating humpback whales. Using empirical and modelling approaches, this research responds directly to the Federal Government strategy for mitigating ship strike, which explicitly flags Moreton Bay as an 'area of concern'. The project has been developed in collaboration with traditional owners and industry, and is expected deliver optimal mitigation measures for the region. Findings further carry implications for similar functional habitats along Australia's humpback whale migratory corridors.Read moreRead less