Identifying Long-range Regulatory Elements Of The Breast Cancer Susceptibility Gene, BRCA1
Funder
National Health and Medical Research Council
Funding Amount
$612,842.00
Summary
BRCA1 is a breast cancer susceptibility gene implicated in both familial and sporadic breast cancers. The mechanisms controlling BRCA1 expression are poorly understood. We will identify DNA sequences critical for regulation of the BRCA1 gene. We hypothesise that these regions are mutational hot spots conferring an increased breast cancer risk. A better understanding of the pathways responsible for promoting BRCA1-associated breast cancer will provide important diagnostic and treatment targets.
Maintenance And Operation Of The Australian Seafood Extension And Advisory Service (AUSEAS)
Funder
Fisheries Research and Development Corporation
Funding Amount
$310,872.22
Summary
Objectives: 1. To provide the post-harvest sector of the Australian seafood industry with technical information and advice that is timely, accurate and relevant. 2. To proactively promulgate the results of research to companies that are well placed to use them. 3. To identify areas where research is needed and the institutes where the work can be done. 4. To promote networking between companies in the post-harvest area by personal contact and publications. 5. To provi ....Objectives: 1. To provide the post-harvest sector of the Australian seafood industry with technical information and advice that is timely, accurate and relevant. 2. To proactively promulgate the results of research to companies that are well placed to use them. 3. To identify areas where research is needed and the institutes where the work can be done. 4. To promote networking between companies in the post-harvest area by personal contact and publications. 5. To provide sales support for selected publications and database maintenance. These include directories, research reports and the FishMAD service, disseminating the results of the national seafood consumption study. 6. Publication of second edition of Australian Seafood Industry Directory 1997-99. Read moreRead less
Chromatin Dynamics As A Driver Of Disease Initiation And Development
Funder
National Health and Medical Research Council
Funding Amount
$419,180.00
Summary
Epigenetic programming ensures that the right genes are expressed in the right amount, in the right cell type at the right time. Our OVERALL AIM is to identify how this programming is altered in certain cancers and dementias and to determine whether this is a cause or driver of disease. This study has great potential to identify the epigenetic marks that will be the best targets for new therapies.
Therapeutic Targeting Of The Colorectal Cancer Epigenome
Funder
National Health and Medical Research Council
Funding Amount
$537,045.00
Summary
Enhancer RNAs (eRNAs) are a new class of noncoding RNA molecules that have been linked to diverse functions that impinge on cancer, but their clinical relevance is unknown. Our work shows that distinct eRNAs are expressed in a subset of cancer and predict which cancer will respond to a cancer therapeutic agent called a BET inhibitor. Our proposal uses sophisticated preclinical models and cutting edge technology to investigate the functional role of enhancers and enhancer templated RNA in cancer.
Organisation Of The Genome During The Development Of Antibody-secreting Cells
Funder
National Health and Medical Research Council
Funding Amount
$886,155.00
Summary
Each cell of our body contains over two metres of DNA that must be correctly packaged in order for our cells to function. We are using cutting-edge molecular biology techniques to study how this DNA circuitry is established in the white blood cells of our immune system that produce antibodies. Our novel approaches will reveal unique strategies to modulate immune responses to our benefit.
Improving Long-term Mortality Rates Following Sepsis.
Funder
National Health and Medical Research Council
Funding Amount
$99,682.00
Summary
It is estimated that 37.9 million patients survive sepsis each year. Studies have demonstrated that among patients who survive for 30 days after admission for sepsis, over 40% die in the following two years. There are currently no guidelines that provide recommendations on post-hospital management of sepsis. This research programme aims to identify those patients at greatest risk of death and implement post-sepsis care with the aim to significantly reduce long-term mortality after sepsis.
Extension Of MSC Certification For Western Australian Fisheries
Funder
Fisheries Research and Development Corporation
Funding Amount
$686,000.00
Summary
The FRDC, WAFIC and MSC have undertaken public perception studies on the support of fishing activities that have shown that the industry has a very low level of support. The Australian public simply does not believe the message given to it by industry and Government. Western Australia has recognised that the very survival of wild-harvest fisheries depends on a paradigm shift in this negative perception and only a credible, internationally recognised, third-party certification of the State's fi ....The FRDC, WAFIC and MSC have undertaken public perception studies on the support of fishing activities that have shown that the industry has a very low level of support. The Australian public simply does not believe the message given to it by industry and Government. Western Australia has recognised that the very survival of wild-harvest fisheries depends on a paradigm shift in this negative perception and only a credible, internationally recognised, third-party certification of the State's fisheries will alter the perception and provide industry with the level of security to invest in its future. The $14.56 million earmarked for third party certification will be split as following: $6.56 million for MSC pre-assessment, full assessment and initial audit and; $2 million per year over 4 years ($8 million) to support Department of Fisheries research and management inputs to the certification process. If the benefits of this investment are to be fully realised for the State and the industry there must be investment in community and industry engagement, and engagement with the post-harvest sector through to the retail and food service. Without such engagement the benefits of certification will not be fully captured. This will require research and testing of cost effective mechanisms to effectively engage. The project builds on the substantial investment by the FRDC in research for Ecosystem Based Fisheries Management. The project will also link with other FRDC activities nationally like the Key Stock Status Report and the trial of the NSW Responsible Fisheries Management Certification project. The whole program of activities in WA that include: A new fisheries Act; MSC certification; and support for FRDC’s marketing function are singularly the largest changes being implemented by a fisheries jurisdiction to improve the future outlook for both capture fisheries and aquaculture. Objectives: 1. To develop and assess communication strategies on how best to obtain commercial fishers support for implementation of third party certification in their fisheries, with the focus being on Marine Stewardship Council (MSC) certification 2. To assess options for promoting MSC to obtain public confidence in the management of WA fisheries 3. To assess different evaluation methodologies for third party certification that are cost effective and improve the delivery of the program for both fishers and the community 4. Develop and trial a practical framework that would deliver a more cost efficient way for a range of smaller, independent, companies in the supply chain to gain MSC Chain of Custody to optimize community recognition and appreciation of Australian MSC certified seafood 5. To work with stakeholders (retail, fisheries management and environmental agencies) to establish where possible equivalence for the third party certification framework that is being developed for WA fisheries Read moreRead less