Synchrotron X-ray Assessment Of Airway Surface Physiology For Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$778,228.00
Summary
We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.
From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
Phytocapping for sustainable waste containment systems and reduction of greenhouse gas emissions and odour from waste disposal sites. Landfills remain the main method of waste disposal in Australia and are a major source of groundwater contamination and greenhouse and odour emissions. This national research program will establish, under a wide range of Australian conditions, whether landfill phytocaps can meet regulatory performance criteria for water infiltration into and gas emissions from clo ....Phytocapping for sustainable waste containment systems and reduction of greenhouse gas emissions and odour from waste disposal sites. Landfills remain the main method of waste disposal in Australia and are a major source of groundwater contamination and greenhouse and odour emissions. This national research program will establish, under a wide range of Australian conditions, whether landfill phytocaps can meet regulatory performance criteria for water infiltration into and gas emissions from closed landfills more effectively, efficiently and sustainably than conventional capping systems. The project will produce (a) a scientific basis for site owners and regulators to agree on the performance and cost of conventional and phyto cover technologies, (b) a manual for the design and permitting of alternative covers and (c)improved scientific prediction of cover performance.Read moreRead less
New approach to sensitivity assessment of complex simulation models for environmental management. The aims are (1) to develop new techniques that improve and extend the capabilities of sensitivity analysis of large and complex computer models for environmental management; and (2) with the industry partners, to test these techniques on models for salinity management in the Murray-Darling Basin. The project's significance is in providing new techniques able to answer a range of model users? questi ....New approach to sensitivity assessment of complex simulation models for environmental management. The aims are (1) to develop new techniques that improve and extend the capabilities of sensitivity analysis of large and complex computer models for environmental management; and (2) with the industry partners, to test these techniques on models for salinity management in the Murray-Darling Basin. The project's significance is in providing new techniques able to answer a range of model users? questions at acceptable computational cost, for complex models with outputs measured in a wide variety of ways. The outcomes will be new sensitivity assessment tools and experience of their use in an environmental application of great importance to Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453434
Funder
Australian Research Council
Funding Amount
$395,077.00
Summary
A new airborne facility for environmental, hydrological, atmospheric and oceanic research: high resolution measurement of soil moisture, temperature and salinity. This proposal seeks to establish a new national capability for airborne remote sensing of key environmental variables. It will enable high-resolution mapping of near-surface soil moisture, land surface salinity and temperature, and ocean surface salinity and temperature. It will be a new tool for hydrologic, atmospheric and oceanic r ....A new airborne facility for environmental, hydrological, atmospheric and oceanic research: high resolution measurement of soil moisture, temperature and salinity. This proposal seeks to establish a new national capability for airborne remote sensing of key environmental variables. It will enable high-resolution mapping of near-surface soil moisture, land surface salinity and temperature, and ocean surface salinity and temperature. It will be a new tool for hydrologic, atmospheric and oceanic researchers, providing unprecedented detail on characteristics critical to our understanding and management of the environment. The small instrument size and weight will enable use of a light aircraft as the observing platform, providing the national (and international) research community with an affordable tool, hitherto unavailable.Read moreRead less
Revolutionising The Diagnosis And Monitoring Of CF Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$818,391.00
Summary
Cystic fibrosis (CF) lung disease starts early in childhood and relentlessly progresses, with early death a common outcome. There is currently no method capable of detecting very early disease onset nor directly assessing the effectiveness of putative treatments. This project will apply our globally unique X-ray imaging tools, which are capable of imaging lung function at any point across the entire lung, for the very early detection of CF and assessment of clinically applicable treatments.
Development of a Bioassay to Measure Xenoestrogens in Environmental Water Samples. Xenoestrogens in water can cause feminization of fish, amphibians and other wildlife, interfere with reproduction and increase cancer. This research aims to develop a new test to measure xenoestrogens in water, based on a measure of the estrogen-activated genes that are switched on when cells are exposed to estrogens. If the research is successful, it will produce the best test in the world for measuring the effe ....Development of a Bioassay to Measure Xenoestrogens in Environmental Water Samples. Xenoestrogens in water can cause feminization of fish, amphibians and other wildlife, interfere with reproduction and increase cancer. This research aims to develop a new test to measure xenoestrogens in water, based on a measure of the estrogen-activated genes that are switched on when cells are exposed to estrogens. If the research is successful, it will produce the best test in the world for measuring the effects of xenoestrogens on mammalian cells. The test can be used to develop better xenoestrogen removal processes, and to set limits for the levels of xenoestrogens permitted in rivers and creeks.Read moreRead less
New understanding and models for two-phase solar thermal particle receivers. The project aims to provide the new understanding of, and computational design tools for, next generation solar thermal particle receivers and their hybrids. Particle receivers, which heat fine particles in suspension, offer much greater efficiency than current tubular receivers, but are presently unreliable due to the poor understanding of the complex and coupled mechanisms that govern their performance. The results ar ....New understanding and models for two-phase solar thermal particle receivers. The project aims to provide the new understanding of, and computational design tools for, next generation solar thermal particle receivers and their hybrids. Particle receivers, which heat fine particles in suspension, offer much greater efficiency than current tubular receivers, but are presently unreliable due to the poor understanding of the complex and coupled mechanisms that govern their performance. The results are expected to speed up the development and roll-out of these devices, to deliver cost-effective, low-emissions energy technologies for future power generation and thermo-chemical processes. The aims will be met by the parallel application of advanced laser diagnostic measurements and computational fluid dynamics modelling techniques.Read moreRead less
Design of novel nanoporous semiconductor materials for clean environment and energy. This project will develop a low cost nanoporous semiconductor device for the capture and conversion of CO2 into fuels by using water and sunlight. This novel approach will deliver a low cost technology that offers clean energy and will help to mitigate global warming.
Novel Methods For Promoting Organ Development And Growth
Funder
National Health and Medical Research Council
Funding Amount
$390,203.00
Summary
A revolutionary new therapy for treatment of growth restricted fetuses and premature babies is being developed through the administration of Colony Stimulating Factor (CSF-1). We have evidence that CSF-1 therapy can promote kidneys and lungs to continue development and maturation after birth. This exciting new finding allows for the application of CSF-1 therapy for both the treatment of premature babies and unborn babies with kidney defects.