Synchrotron X-ray Assessment Of Airway Surface Physiology For Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$778,228.00
Summary
We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.
The separation of carbon dioxide from industrial sources using nanoporous carbon. Carbon nanotubes and nanoporous carbon membranes offer the possibility of low cost energy efficient separations of gas mixtures. Possible applications include the purification of greenhouse gases for sequestration and the purification of hydrogen from reformer gas for use in a hydrogen energy economy. The proposed project involves the development of mathematical models and computer simulations to understand and ....The separation of carbon dioxide from industrial sources using nanoporous carbon. Carbon nanotubes and nanoporous carbon membranes offer the possibility of low cost energy efficient separations of gas mixtures. Possible applications include the purification of greenhouse gases for sequestration and the purification of hydrogen from reformer gas for use in a hydrogen energy economy. The proposed project involves the development of mathematical models and computer simulations to understand and optimise the nanoporous structure for different gas separations, and experimental research to produce the carbon nanoporous materials and determine their effectiveness of gas separation.Read moreRead less
From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
The Predictors Of Asthma And Lung Function Deficits In The Third Decade: Longitudinal Study Of MACS Sibships
Funder
National Health and Medical Research Council
Funding Amount
$1,176,908.00
Summary
This will be the world’s first birth cohort study to use substantial prospective data to investigate how biological, psychosocial, and environmental markers from birth will predict asthma and lung function in the third decade of life. Our findings will be crucial to the development of new policy and practice for the prevention and management of these conditions and uncover crucial risk factors for young adult asthma.
Respiratory failure at birth is a major cause of death and disease in newborn infants. At birth the airways must be cleared of liquid to allow the inhalation of air, but, little is known about the process of lung aeration, because it has not been possible to observe or measure it. We have developed imaging and analytical techniques to observed and measure lung aeration. We will determine ventilation procedures that promote uniform lung aeration and minimise lung injury in ventilated infants.
Use of remote sensing actual evapotranspiration estimates and water delivery data for assessing water use efficiency in an irrigated landscape. Improving management of water in irrigated agriculture will lead to increased sustainability, decreased environmental impacts and increased profitability. Quantifying water use efficiency for an irrigation district is a vital part of improving water management. This project aims to develop new methods for quantifying water use efficiency by combining ac ....Use of remote sensing actual evapotranspiration estimates and water delivery data for assessing water use efficiency in an irrigated landscape. Improving management of water in irrigated agriculture will lead to increased sustainability, decreased environmental impacts and increased profitability. Quantifying water use efficiency for an irrigation district is a vital part of improving water management. This project aims to develop new methods for quantifying water use efficiency by combining actual evapotranspiration estimates with water delivery information at the farm scale for an entire irrigation district. Remote sensing techniques will be utilized to map actual evapotranspiration and water meter data will be combined with cadastral and channel network data to map water delivery.Read moreRead less
Atomically thin membranes to transform chemical separations. Energy-efficient chemical separation is at the heart of modern resource and manufacturing industries, central to a prosperous and sustainable Australia. This project aims to develop next generation membrane technologies to transform chemical separations by employing recent breakthrough in materials discovery and nanofluidics. Expected outcomes include new fundamental understandings on sub-continuum transport physics and new atomically ....Atomically thin membranes to transform chemical separations. Energy-efficient chemical separation is at the heart of modern resource and manufacturing industries, central to a prosperous and sustainable Australia. This project aims to develop next generation membrane technologies to transform chemical separations by employing recent breakthrough in materials discovery and nanofluidics. Expected outcomes include new fundamental understandings on sub-continuum transport physics and new atomically thin membranes that enable energy-efficient separations for processing challenging streams beyond water purification. This project aims to position Australia at the forefront of sustainable separation technology and make the local resource and manufacturing industries more sustainable and globally competitive.Read moreRead less
Integrating dynamic and optimization models for efficient pipeline system operations in an evolving water and energy market. Developing an integrated dynamical and optimisation model for a piped water distribution system will advance Australia's capacity to deploy the most recent optimisation approaches to achieve the high level of efficiency required in the delivery of water to dryland regions. The outcomes of this project will be readily transferable to other regions and indeed other water d ....Integrating dynamic and optimization models for efficient pipeline system operations in an evolving water and energy market. Developing an integrated dynamical and optimisation model for a piped water distribution system will advance Australia's capacity to deploy the most recent optimisation approaches to achieve the high level of efficiency required in the delivery of water to dryland regions. The outcomes of this project will be readily transferable to other regions and indeed other water distribution systems. This will provide capability in securing Australia's water supplies and delivery systems. There may also be associated benefits to other pipeline operators in the oil and gas industries.Read moreRead less
Water information services to boost irrigation productivity. This project aims to develop an integrated irrigation scheduling, benchmarking and forecasting capability delivered through a water ordering portal that is used by most Australian irrigation farmers and many farmers internationally. Ensuring adoption is critical and this will be facilitated through integration into the existing water ordering system. Expected outcomes include improved ability to manage irrigation water through better u ....Water information services to boost irrigation productivity. This project aims to develop an integrated irrigation scheduling, benchmarking and forecasting capability delivered through a water ordering portal that is used by most Australian irrigation farmers and many farmers internationally. Ensuring adoption is critical and this will be facilitated through integration into the existing water ordering system. Expected outcomes include improved ability to manage irrigation water through better use of existing weather observations and forecasts, irrigation data, and satellite observations to inform farmer decisions. This is expected to result in improvement in water productivity, leading to economic benefit and an improved ability to meet growing global food demands.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668400
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
A high-throughput stable isotope ratio mass spectrometer for water resource management and climate change studies. Cave speleothems are highly sensitive to climate and are widely used to investigate past climate variability. Many researchers in Australia are now employing speleothems to find out more about the long-term behaviour of the Australian climate system, especially regarding ENSO. However, progress is inhibited by a lack of appropriate instrumentation capable of meeting the unique deman ....A high-throughput stable isotope ratio mass spectrometer for water resource management and climate change studies. Cave speleothems are highly sensitive to climate and are widely used to investigate past climate variability. Many researchers in Australia are now employing speleothems to find out more about the long-term behaviour of the Australian climate system, especially regarding ENSO. However, progress is inhibited by a lack of appropriate instrumentation capable of meeting the unique demands of speleothem research. Our new mass spectrometer will provide precise, rapid and low-cost isotope analyses of speleothem samples, and in doing so generate exciting and important palaeoclimate data, particularly in the area of pre-instrumental rainfall histories.Read moreRead less