The Microenvironmental Drivers Of T Cell Regulation In Metastatic Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$1,302,611.00
Summary
COX2 inhibitors are drugs commonly used by cancer patients to relieve pain and inflammation. Using human breast cancer samples and mouse models of breast cancer, we show that pathways targeted by these drugs provide an immunological brake that prevents T cells being activated as strongly as they could be, and which has not been studied. This project is expected to yield important anti-cancer targets that could be used to develop a new class of cancer drugs.