Signal Integration During The Early B Cell/CD4+ T Cell Interactions In T-dependent Antibody Responses
Funder
National Health and Medical Research Council
Funding Amount
$128,783.00
Summary
Effective humoral immunity results from the complex interaction of B and T lymphocytes. STAT3, CD40L, SAP and ICOS are molecules that are involved in this interaction. Genetic mutations of these molecules result in well defined primary immunodeficiencies underscoring their importance. This study aims to characterise the integration of these early signals as well as other inputs that B cells receive and characterise the CD4+ cells that provide this help.