Phagocytic Clearance And Immune Activation In Malaria
Funder
National Health and Medical Research Council
Funding Amount
$564,644.00
Summary
Macrophage white blood cells clear malaria infected cells by eating them, by three routes- by recognising ANTIBODIES or COMPLEMENT on the cell surface, or by the cell BINDING directly to the macrophage. Each has different results, such as amounts of cytokines produced. Cytokines clear malaria; in excess they can cause fatal immune pathology. We will investigate how variations in amount of antibody and complement and route of uptake of malaria infected cells might determine malaria outcome.
S100A8/A9 As A Target In Metabolic Diseases To Inhibit The Acceleration Of Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$554,990.00
Summary
Obesity and diabetes are the leading cause of premature death, due to accelerated cardiovascular disease (CVD). The abundance of blood monocytes influences the progression and regression of CVD. We discovered that S100A8/A9 promotes monocyte production in obesity and diabetes. This project will explore how S100A8/A9 is produced in diabetes and obesity and if blocking its function using a novel drug will prevent obesity and diabetes associated CVD.
Unconventional Mechanisms For Activating The NLRP3 Inflammasome
Funder
National Health and Medical Research Council
Funding Amount
$747,031.00
Summary
Many inflammatory driven diseases such as arthritis, atherosclerosis and septic shock are also associated with cell death. This project will identify, at the molecular level, how cell death signalling specifically acts to trigger pathological inflammation. As such, it will identify novel targets for the development of next generation anti-inflammatory drugs.
A Novel Lipid Sensitive Kinase And Its Role In Obesity-induced Inflammation And Insulin Resistance.
Funder
National Health and Medical Research Council
Funding Amount
$560,045.00
Summary
It is now apparent that obesity leads to chronic low grade inflammation which results in insulin resistance or pre-diabetes. The mechanisms that link obesity-induced inflammation to insulin resistance are not well understood, but involve lipid oversupply. We have preliminary data identifying that a protein, not known to previously play a role in metabolic diseases, is a critical mediator of lipid-induced inflammation. We will investigate the clinical potential of blocking this protein.
Projecting Difference: A History of the Practice and Politics of French Cinema since 1980. This cultural history project has dual aims. Firstly, it will examine how French cinema, as a narrative art, has since the late 20th century become a major vector for defining cultural identity (partially eclipsing the role traditionally occupied by literature). On the other hand, it will document and analyse the processes by which cinema practice - diverse and often fractiously critical of existing politi ....Projecting Difference: A History of the Practice and Politics of French Cinema since 1980. This cultural history project has dual aims. Firstly, it will examine how French cinema, as a narrative art, has since the late 20th century become a major vector for defining cultural identity (partially eclipsing the role traditionally occupied by literature). On the other hand, it will document and analyse the processes by which cinema practice - diverse and often fractiously critical of existing political structures - has become a central symbolic weapon in the French State's political defence of cultural autonomy and difference in a globalising world. The resulting synthesis will provide extensive new understanding of the dynamics of contemporary France.Read moreRead less
The global self: screening the history of human rights in the 20th century to the present. This project will research the history and theory of human rights as represented in film and new media. It will analyse the origins and development of human rights theory and document the changes in films about human rights in order to understand how we now conceptualise human rights in the twenty-first-century.
Consuming Celebrity: Female stardom and gay subcultural reception. This project explores the function of celebrity in modern culture through a detailed case study of gay subcultural receptions of female stardom. The female star or ?diva? has been an influential figure in gay subcultures since the nineteenth century where it has inspired significant and enduring productions of gay selfhood. The project explores the histories of gay ?diva worship? to analyse the role and uses of stardom in formati ....Consuming Celebrity: Female stardom and gay subcultural reception. This project explores the function of celebrity in modern culture through a detailed case study of gay subcultural receptions of female stardom. The female star or ?diva? has been an influential figure in gay subcultures since the nineteenth century where it has inspired significant and enduring productions of gay selfhood. The project explores the histories of gay ?diva worship? to analyse the role and uses of stardom in formations of cultural identity. Through scholarly publications, the study will make major contributions to our understanding of not only gay culture and history, but the significance of celebrity in modern cultural life.Read moreRead less
Improving Communication with Aboriginal English Speakers: A Study of cultural conceptualisations in Aboriginal English. The project will explore cultural conceptualisations in Aboriginal English. Often unfamiliarity with Aboriginal cultural conceptualisations on the part of non-Aboriginal people leads to miscommunication, disadvantaging Aboriginal speakers, especially in institutional contexts (for example, schoolrooms, courtrooms, Centrelink offices). The aim of this study is to alleviate such ....Improving Communication with Aboriginal English Speakers: A Study of cultural conceptualisations in Aboriginal English. The project will explore cultural conceptualisations in Aboriginal English. Often unfamiliarity with Aboriginal cultural conceptualisations on the part of non-Aboriginal people leads to miscommunication, disadvantaging Aboriginal speakers, especially in institutional contexts (for example, schoolrooms, courtrooms, Centrelink offices). The aim of this study is to alleviate such problems, and significantly advance Aboriginal English research, by exploring culturally constructed conceptualisations, in particularly cultural-conceptual metaphor, underlying the use of Aboriginal English, using the the analytical tools of Cultural Linguistics. The study will also make a significant contribution to the development of Cultural Linguistics. Read moreRead less
Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belongin ....Locating LGBTIQ+ youth in the archive: Telling new stories for belonging. This project aims to produce the first study of LGBTIQ+ youth in Australia’s past and investigate what these histories mean to LGBTIQ+ youth today. We will generate new knowledge of Australian LGBTIQ+ history and links between historical knowledge and wellbeing in relation to LGBTIQ+ youth. Working with LGBTIQ+ youth we will also develop new archival storytelling techniques, theorising archives as ‘laboratories of belonging’. In doing so, the project forges links between cultural studies of storytelling, LGBTIQ+ youth studies and Australian history. Benefits include innovations in reparative historical methodologies, new resources for the GLAM, youth and education sectors and improvements in LGBTIQ+ youth wellbeing.Read moreRead less