Aspirin For The Prevention Of Cognitive Decline In The Elderly: A Neuro-Vascular Imaging Study (ENVIS-ion) From ASPREE
Funder
National Health and Medical Research Council
Funding Amount
$1,341,232.00
Summary
The ENVIS-ion trial will examine whether Aspirin is effective in delaying the onset of worsening of thinking and memory abilities in healthy older adults. Magnetic resonance imaging (MRI) of brain structure will detect markers of early worsening of thinking and memory abilities. Blood vessels in the back of the eye (retina) share many features with vessels in the brain. We will compare whether aspirin lessens changes over time of features shown with brain MRI and retinal photography.
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$14,927,045.00
Summary
This program focuses on understanding the development of immunity during infection or inflammatory diseases using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune or inflammatory diseases.
Determinant Spreading And The Role Of The MHC Class II Region In Systemic And Organ-specific Autoimmunity
Funder
National Health and Medical Research Council
Funding Amount
$140,570.00
Summary
Autoimmune diseases are among the most important group of disorders affecting the adult population. In these diseases the immune system damages organs and tissues producing widespread pathology (systemic autoimmunity such as Lupus erythematosus) or localised disease (organ-specific autoimmunity such as insulin dependent diabetes). We understand very little about how and why the immune system attacks the body's own tissues. This study examines how antibodies and T lymphocytes are formed against c ....Autoimmune diseases are among the most important group of disorders affecting the adult population. In these diseases the immune system damages organs and tissues producing widespread pathology (systemic autoimmunity such as Lupus erythematosus) or localised disease (organ-specific autoimmunity such as insulin dependent diabetes). We understand very little about how and why the immune system attacks the body's own tissues. This study examines how antibodies and T lymphocytes are formed against components located inside cells of the body. The study involves genetically modifying mice by introducing key human genes which influence the development of autoimmunity. In this way the role of these human genes can be examined experimentally without having to work exclusively on patients. We also hope that these mice might be important in creating new models of celiac disease and insulin dependent diabetes. The proposed experiments should tell us how these genes contribute to the development of autoimmune disease. This understanding could be relevant devising treatments and interventions to prevent autoimmune diseases.Read moreRead less
Antigen Presentation, Recognition And The Immune Response
Funder
National Health and Medical Research Council
Funding Amount
$15,780,848.00
Summary
This program focuses on understanding the development of immune response to viruses and other infectious agents using a broad array of techniques to dissect the function of various immune cell types and to explore the relationship between structure and function of important cell surface molecules. These studies will improve our ability to design new generation vaccines for combating infectious diseases, controlling cancer, or limiting autoimmune diseases like diabetes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775646
Funder
Australian Research Council
Funding Amount
$636,000.00
Summary
Surface and Magnetic structure of crystalline materials. This proposal brings together significant research groups in La Trobe University, Monash University, the University of Western Australia, Newcastle University and Sydney University to establish a unique materials characterisation facility which will enable surface and magnetic structures of technologically significant materials to be determined. It will support developments in the areas of new magnetic phenomenon which is used in magnetic ....Surface and Magnetic structure of crystalline materials. This proposal brings together significant research groups in La Trobe University, Monash University, the University of Western Australia, Newcastle University and Sydney University to establish a unique materials characterisation facility which will enable surface and magnetic structures of technologically significant materials to be determined. It will support developments in the areas of new magnetic phenomenon which is used in magnetic sensing and in the exploration of processes of size reduction for electronic devices. It will enable this new, world leading technology, to be applied to surface structures relevant in the areas of nanotechnology and catalysis.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668065
Funder
Australian Research Council
Funding Amount
$623,000.00
Summary
High resolution images of surfaces. This proposal brings together significant research groups in La Trobe University, Macquarie University, the University of Western Australia and ANSTO to work in areas which will enhance Australia's capability in the area of Magnetic devices and spintronics. It will support developments in the areas of new magnetic phenomenon which is used in magnetic sensing and in the exploration of processes of size reduction for electronic devices. It will enhance the acc ....High resolution images of surfaces. This proposal brings together significant research groups in La Trobe University, Macquarie University, the University of Western Australia and ANSTO to work in areas which will enhance Australia's capability in the area of Magnetic devices and spintronics. It will support developments in the areas of new magnetic phenomenon which is used in magnetic sensing and in the exploration of processes of size reduction for electronic devices. It will enhance the access of undergraduates and postgraduates to the emerging technologies. It will connect Australia to internationally significant research outcomes leading to, for example, new magnetic and electronic devices with a continuing decrease in their size. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775614
Funder
Australian Research Council
Funding Amount
$150,000.00
Summary
National Electromagnetic Characterization Facility for Advanced Electronic and Biomaterials. The proposed Material Characterisation Facility using non-destructive methods will be unique to Australia. Precise characterisation of advanced materials such as dielectrics and superconductors using the facility will progress emerging technologies within the electronic and communication research area. The inclusion of a microwave scanning test bed within the laboratory will allow engineers, scientists, ....National Electromagnetic Characterization Facility for Advanced Electronic and Biomaterials. The proposed Material Characterisation Facility using non-destructive methods will be unique to Australia. Precise characterisation of advanced materials such as dielectrics and superconductors using the facility will progress emerging technologies within the electronic and communication research area. The inclusion of a microwave scanning test bed within the laboratory will allow engineers, scientists, biologists and medical scientists to safely detect the intrinsic electromagnetic properties of electronic materials and tumours in biological tissues or poor quality agricultural produce. This comprehensive material characterisation facility will therefore benefit the peoples of Australasia in many significant and diverse ways.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100081
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The pr ....Combined scanning tunnelling microscope system for materials characterisation and manipulation at nano scale. The proposed facility is unique in Australia and will substantially enhance national research capabilities in nano-materials, nanotechnology and biotechnology. The proposed infrastructure project will bring more than 20 leading Australian research groups from 10 institutions together to create an outstanding platform to underpin close collaborations among members in a broad field. The proposed facility will provide significant benefits to Australian researchers in drug design and delivery, nano-material design and characterisation at nano scale for advanced materials, and promotion of renewable energy. This represents a great opportunity to make discoveries and breakthroughs in frontier science and technology in Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100054
Funder
Australian Research Council
Funding Amount
$824,080.00
Summary
Facility for electric and magnetic probes of materials at extreme conditions. This project aims to establish a readily accessible facility for measurement of electric and magnetic properties of materials under extreme temperature, magnetic field, and sensitivity conditions. The expected outcome is to build capacity for and support world-leading research into novel topological materials, atomically thin materials, materials with strong light-matter interactions and magnetic materials. The benefit ....Facility for electric and magnetic probes of materials at extreme conditions. This project aims to establish a readily accessible facility for measurement of electric and magnetic properties of materials under extreme temperature, magnetic field, and sensitivity conditions. The expected outcome is to build capacity for and support world-leading research into novel topological materials, atomically thin materials, materials with strong light-matter interactions and magnetic materials. The benefits to society are new devices for efficient generation, storage, transmission and switching of energy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100128
Funder
Australian Research Council
Funding Amount
$670,000.00
Summary
Helium and neon ion microscope for sub nanometer imaging and fabrication. The project's proposed instrument would add a new desperately needed capability to Australia's high resolution microscopy centre and nano fabrication facility and enable a wide range of users to image, measure, build and design complex nanostructures at the atomic level and upwards.