Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
Exploring the gene regulation networks governing mitochondrial biogenesis in Arabidopsis. Mitochondria, subcellular organelles that perform many functions indispensable to plant growth and productivity, are dynamic compartments whose protein complement changes dramatically during plant development and under stress. Yet, the cellular processes that regulate the production of these organelles are virtually unknown. By combining conventional approaches with an extremely powerful holistic method for ....Exploring the gene regulation networks governing mitochondrial biogenesis in Arabidopsis. Mitochondria, subcellular organelles that perform many functions indispensable to plant growth and productivity, are dynamic compartments whose protein complement changes dramatically during plant development and under stress. Yet, the cellular processes that regulate the production of these organelles are virtually unknown. By combining conventional approaches with an extremely powerful holistic method for simultaneously examining the expression patterns of every gene in the model plant Arabidopsis, this project will identify proteins that regulate mitochondrial biosynthesis and uncover the gene networks that these proteins control. The project outcomes will provide new opportunities for the rational manipulation of plant growth and productivity.Read moreRead less
Genome Approaches to Investigate Metabolic Coordination in Plant Cells. Metabolism of C and N in legume nodules requires interaction between the symbiotic bacteria and plant organelles, particularly metabolism in plastids and mitochondria. Fixed N is assimilated through the de novo synthesis of purines in both plastids and mitochondria. However, each of the nine pathway enzymes is encoded by a single gene, indicating each protein is targeted to both organelles. Purine metabolism will provide ....Genome Approaches to Investigate Metabolic Coordination in Plant Cells. Metabolism of C and N in legume nodules requires interaction between the symbiotic bacteria and plant organelles, particularly metabolism in plastids and mitochondria. Fixed N is assimilated through the de novo synthesis of purines in both plastids and mitochondria. However, each of the nine pathway enzymes is encoded by a single gene, indicating each protein is targeted to both organelles. Purine metabolism will provide a model to assess the more general occurrence of dual-targeted proteins in plants. The aim is to identify and eventually exploit the signalling mechanism(s) that mediate communication between plastids and mitochondria.Read moreRead less
Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. T ....Multiliteracies for addressing disadvantage in senior school science. Multiliteracies for addressing disadvantage in senior school science. This project aims to develop discipline-specific pedagogies in senior physics, chemistry and biology to improve disadvantaged students’ engagement and achievement. Many students from disadvantaged backgrounds fail to develop the linguistic precision and symbolic representational dexterity needed to comprehend and communicate senior school science concepts. These pedagogies will ‘infuse’ multiliteracies in senior school science to improve access to science-based pathways for these students, and enable them to understand progressively more complex scientific concepts and demonstrate this in examinations. This project is expected to improve student retention, arrest declining enrolments in senior school science, and increase young people working in science.Read moreRead less
Using immersive virtual reality to enhance students’ science visualisation. This project aims to investigate the potential of advanced visualisation technology, immersive virtual reality, as a collaborative learning environment to support students to explore their ideas and learn a core chemistry concept, molecular structures and functions. Incorporating both data analytics and qualitative video analysis, the project will establish a deep understanding of how students learn about the molecular w ....Using immersive virtual reality to enhance students’ science visualisation. This project aims to investigate the potential of advanced visualisation technology, immersive virtual reality, as a collaborative learning environment to support students to explore their ideas and learn a core chemistry concept, molecular structures and functions. Incorporating both data analytics and qualitative video analysis, the project will establish a deep understanding of how students learn about the molecular world within an immersive virtual reality environment in relation to the learners’ experience, chemistry content, visual representations, learning tasks, and design features. The project will recommend evidence-driven design considerations for learning resources development and further educational research with advanced technologies.Read moreRead less
The online future of Science and Engineering education: The essential elements of laboratory-based learning for remote-access implementation. Laboratory classes are a critical part of science and engineering degree programs, but there has been little research into what actually takes place within them. Remote laboratories, in which students control equipment via the internet, are one potential solution for accommodating rising numbers of students, but the interfaces must be developed to effectiv ....The online future of Science and Engineering education: The essential elements of laboratory-based learning for remote-access implementation. Laboratory classes are a critical part of science and engineering degree programs, but there has been little research into what actually takes place within them. Remote laboratories, in which students control equipment via the internet, are one potential solution for accommodating rising numbers of students, but the interfaces must be developed to effectively support student learning. This project will investigate how students interact with equipment, each other, and with laboratory demonstrators in order to determine the crucial components of effective laboratory learning experiences. It will identify and characterise the interactions of students in laboratory classes, and develop mechanisms to support these interactions remotely.Read moreRead less
Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This pr ....Engaging Students during the Early Years of Secondary School. This project aims to design, test and share sustainable strategies to support teachers and enable students from low socioeconomic communities to achieve success. The greatest decreases in students’ interest and effort occur when they transition into secondary school, with students from low socioeconomic communities at greatest risk of disengagement. What can teachers do to engage their students during this key life transition? This project plans to identify teacher behaviours that motivate students in their first year at secondary school. Using an experimental design with a representative sample of 150 teachers and 1500 students in low socioeconomic areas across three states, the project plans to test whether an online professional learning program for teachers can improve student engagement and achievement. This cost-effective and scalable intervention is designed for widespread dissemination to Australian teachers.Read moreRead less
Recirculating Indigenous traveling songs. This project aims to develop new understandings of how unrestricted Indigenous traveling songs have spread across vast geographic and linguistic boundaries in Australia, investigating ways these songs can contribute to greater social connectedness today. It intends to energise collaborative networks across Indigenous communities, language centres, and holding institutions around the world. Forging models to reinvigorate the performance of traveling songs ....Recirculating Indigenous traveling songs. This project aims to develop new understandings of how unrestricted Indigenous traveling songs have spread across vast geographic and linguistic boundaries in Australia, investigating ways these songs can contribute to greater social connectedness today. It intends to energise collaborative networks across Indigenous communities, language centres, and holding institutions around the world. Forging models to reinvigorate the performance of traveling songs across a wide and diverse range of interconnected localities, this project should advance the potential for Indigenous performance culture to contribute to language revitalisation, cultural identity, and the facilitation of cross-cultural diplomacy in national and international contexts.Read moreRead less
Fine Tuning: A Reconciliation of Indigenous and Western Musical Traditions. Focusing on central Australian song lines, the project strengthens our knowledge, understanding and application of the intricate tuning systems that underpin traditional Indigenous musical practices. Employing a unique methodology that combines Indigenous and contemporary Western musical performance practices with cutting-edge digital technologies, the project will show how the highly nuanced and sophisticated tunings at ....Fine Tuning: A Reconciliation of Indigenous and Western Musical Traditions. Focusing on central Australian song lines, the project strengthens our knowledge, understanding and application of the intricate tuning systems that underpin traditional Indigenous musical practices. Employing a unique methodology that combines Indigenous and contemporary Western musical performance practices with cutting-edge digital technologies, the project will show how the highly nuanced and sophisticated tunings at the heart of Indigenous music-making can be preserved when transposed to contemporary Western art music contexts. In so doing, the case is made for a more genuine, equitable dialogue between Indigenous and non-Indigenous music-makers, to the mutual benefit of musicians, audiences, and society at large. Read moreRead less