Preventing Adverse Effects Of Matrix Metalloproteinases In Diabetic Wound Healing
Funder
National Health and Medical Research Council
Funding Amount
$387,784.00
Summary
Treatment of diabetic foot ulcers presents a significant challenge to diabetic patients and the health care system. Despite concerted treatment, many ulcers do not heal and it is this failure to heal which eventually leads to deep-seated infection and amputation. For these reasons development of new therapeutic strategies to improve wound healing in diabetes is of critical importance. In this study we investigate the role of MMPs in particular MMP-9 in diabetic wounds and examine whether MMP inh ....Treatment of diabetic foot ulcers presents a significant challenge to diabetic patients and the health care system. Despite concerted treatment, many ulcers do not heal and it is this failure to heal which eventually leads to deep-seated infection and amputation. For these reasons development of new therapeutic strategies to improve wound healing in diabetes is of critical importance. In this study we investigate the role of MMPs in particular MMP-9 in diabetic wounds and examine whether MMP inhibition will improve wound healing in diabetes.Read moreRead less
Improving The Management Of Diabetes In Pregnancy In Remote Australia
Funder
National Health and Medical Research Council
Funding Amount
$2,117,449.00
Summary
This study aims to optimise the management of diabetes in pregnancy (both gestational diabetes and pre-existing type 2 diabetes) and post-partum follow-up of these high risk women in order to reduce the risk of future chronic disease among women and their children. The proposal involves scale-up of successful initiatives that we have developed as part of the NT DIP Partnership, scale-up within the Northern Territory (NT) and to Far North Queensland (FNQ).
Obesity And Its Metabolic Associations In Relation To Bariatric Surgery And Maternal-fetal Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$140,949.00
Summary
My research will examine the effects of maternal obesity, diabetes and smoking on outcomes evidence at birth in the offspring. Bariatric surgery is the most effective means to achieve sustained weight loss in obese patients and may improve metabolic abnormalities and complications. My research will explore the benefits of bariatric surgery in obese patients with type 2 diabetes with or without the addition of a glucose-like peptite-1 (GLP-1) agonist, liraglutide.
Pregnancy And Neonatal Diabetes Outcomes In Remote Australia (PANDORA) Cohort
Funder
National Health and Medical Research Council
Funding Amount
$2,395,410.00
Summary
The PANDORA study is a longitudinal birth cohort study recruited from a clinical register of Northern Territory women with diabetes in pregnancy (DIP). We will also recruit a comparator group of mothers without DIP and babies. Follow-up of mothers and infants to 3 years post-delivery will be from medical records, questionnaires and clinical assessment. Rates of progression to type 2 diabetes will be assessed among mothers, and growth, feeding patterns and diabetes risk markers among infants.
Outcomes In Early Diagnosis And Intervention For Gestational Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$162,876.00
Summary
Gestational diabetes mellitus (GDM) is a common complication of pregnancy with significant maternal and fetal consequences. The benefits of screening and treatment for GDM after 24 weeks’ gestation are well known, however there is little evidence for early screening and intervention for women with high risk for GDM. The primary aim of this study is to determine whether early diagnosis and intervention improves pregnancy outcomes in GDM, specifically fetal overgrowth.