Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate model ....Development of mock circulatory system for complex haemodynamic modelling. This project aims to develop a unique mock experimental system to study blood flow dynamics in anatomically realistic coronary artery phantoms. The field of cardiology involves complex fluid dynamic problems, which require the expertise of the fluid dynamics engineer to understand the hemodynamics. Significant innovation in manufacturing and experimental measurement methodologies will be required to develop accurate models, which will be designed to allow the partner organisation to undertake further hemodynamic research.Read moreRead less
The fluid mechanics of dynamically constricted tubes in pulsatile flow. This project is aimed at advancing the fundamental understanding of flow instability, the transition to turbulence and the effect on wall shear stress, in a dynamically constricted tube flow. The project will provide the first accurately resolved experimental flow analysis, using tomographic particle imaging velocimetry and 3D laser doppler anemometry, conducted on a novel experimental model, and will resolve, for the first ....The fluid mechanics of dynamically constricted tubes in pulsatile flow. This project is aimed at advancing the fundamental understanding of flow instability, the transition to turbulence and the effect on wall shear stress, in a dynamically constricted tube flow. The project will provide the first accurately resolved experimental flow analysis, using tomographic particle imaging velocimetry and 3D laser doppler anemometry, conducted on a novel experimental model, and will resolve, for the first time, turbulence characteristics of the dynamic constriction, using direct numerical simulation with a novel moving boundary implementation. The outcomes will provide the key link between fluid mechanics and wall shear stress, allowing future progress to be made in elucidating the causes of cardiovascular disease.
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Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as rest ....Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.Read moreRead less
A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools ....A multiplex microscope platform to define molecular events in fluid systems. This project aims to develop a novel microscopy platform that will enable the visualisation and quantification of molecular events occurring under fluid shear stress. The project will generate new knowledge in platelet biology that will allow characterisation and prediction of key molecular and morphological changes occurring across a blood thrombus under flowing conditions as found in the blood vessels. These new tools and the imaging platform will have applications for researchers wishing to visualise small and rapid molecular events in four dimensions (length, width, height and across time) under fluid shear stress, which is applicable across a range of industries. The project expects to deliver the next generation of intravital microscopes that can visualise and quantify events in a challenging flow environment.Read moreRead less
Tailoring surface properties to maximise boundary slip for microfluidic applications. Overcoming the huge hydrodynamic resistance that slows down liquid flow in confined spaces is a technical and scientific challenge. The project will need to answer the question: what interfacial properties control liquid slip on solid surfaces? Surfaces will be designed to mimic real world examples that present strong drag reduction.
Machine Learning and Shape Optimisation of Fluid-Structure Interactions. This project aims to address vibrations of solid structures by utilising a combination of advanced experimental and computational methods. This project expects to generate new knowledge in the area of flow-induced vibrations utilising the new techniques of machine learning and evolutionary shape optimisation. Expected outcomes of this project include greatly accelerated discovery of mechanisms leading to structural vibratio ....Machine Learning and Shape Optimisation of Fluid-Structure Interactions. This project aims to address vibrations of solid structures by utilising a combination of advanced experimental and computational methods. This project expects to generate new knowledge in the area of flow-induced vibrations utilising the new techniques of machine learning and evolutionary shape optimisation. Expected outcomes of this project include greatly accelerated discovery of mechanisms leading to structural vibrations and optimising structure geometries to either enhance or suppress the vibrations. This should provide significant benefits, such as the design strategies for improved energy harvesters, such as current oscillators, or more stable structures, such as platforms for offshore wind turbines.
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Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
Special Research Initiatives - Grant ID: SR180100021
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
PFAS source zone remediation by foam fractionation and in situ fluidisation. This project aims to develop two methods for the in situ remediation of per- and poly-fluroalkyl substances (PFAS) contamination, downhole foam fractionation for in situ groundwater treatment, and in situ fluidisation for soil treatment, both separately and in combination. Using these methods, PFASs will be removed in the form of a foam, which will be extracted as a liquid concentrate. These techniques could enable PFAS ....PFAS source zone remediation by foam fractionation and in situ fluidisation. This project aims to develop two methods for the in situ remediation of per- and poly-fluroalkyl substances (PFAS) contamination, downhole foam fractionation for in situ groundwater treatment, and in situ fluidisation for soil treatment, both separately and in combination. Using these methods, PFASs will be removed in the form of a foam, which will be extracted as a liquid concentrate. These techniques could enable PFAS removal efficiencies of greater than 90%, providing entirely new methods for the aggressive removal of PFAS from contaminated source zones. This project will enable the rapid removal of the bulk of the PFAS present in soils and groundwater and reduce the potential for further spreading.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100042
Funder
Australian Research Council
Funding Amount
$340,000.00
Summary
Next generation facility to measure microfluidic flows. Microfluidics is ubiquitous in society - for example, biofluids and engineered lab-on-a-chip platforms. This project aims to establish a novel flow measurement facility tailored for microfluidic flows with capabilities beyond current commercial flow diagnostic systems. This will enable engineers and scientists to probe the fluid dynamics of these flows with unprecedented detail to explain their underlying physical mechanisms. Beyond fluidic ....Next generation facility to measure microfluidic flows. Microfluidics is ubiquitous in society - for example, biofluids and engineered lab-on-a-chip platforms. This project aims to establish a novel flow measurement facility tailored for microfluidic flows with capabilities beyond current commercial flow diagnostic systems. This will enable engineers and scientists to probe the fluid dynamics of these flows with unprecedented detail to explain their underlying physical mechanisms. Beyond fluidic measurement, the facility provides the capacity to accurately observe micro-organisms, biological activity (cell adhesion, thrombus stability, fluorescent receptor markers), thermal collector systems (high flux, microchannel-based solar receivers), and many more mechanical phenomena at the micro-scale.
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Discovery Early Career Researcher Award - Grant ID: DE160100131
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Multifunctional micro/nano-engineered solar thermal receivers. This project is designed to develop a new class of thermal receivers that overcome key challenges in today's concentrating solar thermal systems. The development of accurate micro/nanofabrication and characterisation techniques in recent years has made it possible to achieve thermofluid devices that are engineered from the bottom up to achieve high performance at relatively low cost. This project aims to develop a new class of solar ....Multifunctional micro/nano-engineered solar thermal receivers. This project is designed to develop a new class of thermal receivers that overcome key challenges in today's concentrating solar thermal systems. The development of accurate micro/nanofabrication and characterisation techniques in recent years has made it possible to achieve thermofluid devices that are engineered from the bottom up to achieve high performance at relatively low cost. This project aims to develop a new class of solar thermal receivers which use micro/nanotechnology to directly absorb concentrated solar energy with very little pumping power and minimal radiative heat loss. By tailoring the geometry and materials inside the receiver, the project expects to achieve a unique level of integrated optical, heat transfer and fluid flow control.Read moreRead less