Complete blood fractionation using a low-cost microfluidic system. This project aims to understand particle focusing in inertial microfluidic systems to design efficient devices for cell sorting. The field of microfluidics could ultimately advance medical research but device design is primitive. Microfluidic particle separations are not thoroughly simulated before fabrication to predict performance. This project is expected to accelerate progress in design of efficient microfluidic devices. The ....Complete blood fractionation using a low-cost microfluidic system. This project aims to understand particle focusing in inertial microfluidic systems to design efficient devices for cell sorting. The field of microfluidics could ultimately advance medical research but device design is primitive. Microfluidic particle separations are not thoroughly simulated before fabrication to predict performance. This project is expected to accelerate progress in design of efficient microfluidic devices. The knowledge and models developed in this project should help design and develop a microfluidic device for efficient fractionation of complex fluids into valuable components.Read moreRead less
Diamond glass: An all-carbon technology for neural networks and biosensing. This project aims to use plasma deposition to synthesise diamond glass with the highest purity and the most diamond-like character so that it meets the strict requirements for emerging device applications. The extreme properties of diamond glass arise from the diamond-like bonding of the majority of its atoms. This amorphous, wide bandgap semiconductor is also the hardest known glass. The maximum diamond-like content pos ....Diamond glass: An all-carbon technology for neural networks and biosensing. This project aims to use plasma deposition to synthesise diamond glass with the highest purity and the most diamond-like character so that it meets the strict requirements for emerging device applications. The extreme properties of diamond glass arise from the diamond-like bonding of the majority of its atoms. This amorphous, wide bandgap semiconductor is also the hardest known glass. The maximum diamond-like content possible in diamond glass coatings is unknown, so determining its ultimate performance is difficult. Expected applications include medical diagnostics, non-volatile memories and programmable chips.Read moreRead less
Reproductive Autonomy in the Genomic Age. This project aims to provide a better way to help people to think and reflect about new genetic tests in pregnancy. These tests are on the rise. Yet they are occurring in a setting that is overly individualistic and underplays problems that can come from increased information and choice. This project will involve an interdisciplinary team to generate new theoretical and practical knowledge to re-frame the concept of 'reproductive autonomy'. Expected outc ....Reproductive Autonomy in the Genomic Age. This project aims to provide a better way to help people to think and reflect about new genetic tests in pregnancy. These tests are on the rise. Yet they are occurring in a setting that is overly individualistic and underplays problems that can come from increased information and choice. This project will involve an interdisciplinary team to generate new theoretical and practical knowledge to re-frame the concept of 'reproductive autonomy'. Expected outcomes include new bioethics knowledge, innovations in research methodologies, new data and recommendations for practice. The project will provide benefits by generating the first analysis of how reproductive autonomy needs to change to ensure new tests in pregnancy are offered and used well.Read moreRead less
A comparative sociocultural and bioethical study of uterus transplants . This socio-cultural study aims to undertake a comparative study of the new Australian Uterine Transplant (UTx) trial with established and emerging UTx programs in the US and India. Expected outcomes of this project include: enhanced understandings of the experiences and meanings of uterine transplant for women donors, recipients and staff involved in UTx trials; an exploration of the ethical issues raised by this technolog ....A comparative sociocultural and bioethical study of uterus transplants . This socio-cultural study aims to undertake a comparative study of the new Australian Uterine Transplant (UTx) trial with established and emerging UTx programs in the US and India. Expected outcomes of this project include: enhanced understandings of the experiences and meanings of uterine transplant for women donors, recipients and staff involved in UTx trials; an exploration of the ethical issues raised by this technology; and a comparison of social responses to uterine transplants across different societies.This study is anticipated to provide theoretical insights on the social and ethical impacts of this technology for improved public policy responses. Read moreRead less
Understanding the Australian public's expectations of personalised genomics. This multi-disciplinary project aims to be the first to explore the Australian public's awareness of new developments in genetic science that allow healthy individuals to access their own genetic makeup. Called 'personal genomics', this broad group of genetic tests can be used for a variety of purposes that include ancestry, paternity, sporting ability and health. These tests are developing at a rapid rate yet little is ....Understanding the Australian public's expectations of personalised genomics. This multi-disciplinary project aims to be the first to explore the Australian public's awareness of new developments in genetic science that allow healthy individuals to access their own genetic makeup. Called 'personal genomics', this broad group of genetic tests can be used for a variety of purposes that include ancestry, paternity, sporting ability and health. These tests are developing at a rapid rate yet little is known about why, how and where they are used by the public. This project will employ a mixed methods approach to examine how the public might engage with this new technology. The research aims to help define educational strategies and supports and thereby to inform national policy for personal genomics.Read moreRead less
The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide. Basic biochemistry and the metabolic regulation of proliferation remain as the fundamental building blocks of knowledge in cell biology that have enabled breakthrough advances in biology and medicine. Polyamines are unique and ubiquitous low-Mr amines that play vital roles in many biological processes, including proliferation, DNA/RNA synthesis, etc. This proposal will mechanistically dissect the "new" biochemistry of polyami ....The “New” Biochemistry of Polyamines: When Metabolic Pathways Collide. Basic biochemistry and the metabolic regulation of proliferation remain as the fundamental building blocks of knowledge in cell biology that have enabled breakthrough advances in biology and medicine. Polyamines are unique and ubiquitous low-Mr amines that play vital roles in many biological processes, including proliferation, DNA/RNA synthesis, etc. This proposal will mechanistically dissect the "new" biochemistry of polyamines, as we have discovered that polyamines are regulated by iron at 2-major levels, involving >10-key polyamine pathway proteins. This proposal represents first-in-field studies specifically designed to dissect mechanisms involved in this relationship. Our Central Hypothesis is that iron regulates polyamine metabolism.Read moreRead less
A novel platform-technology for long-term subcutaneous neurophysiology. This project aims to develop a novel miniature device for subcutaneous and tetherless brain sensing. It addresses the lack of a device solution for brain-sensing that combines ultra-long-term reliable sensing capability and small dimensions for minimally-invasive procedures. We achieve this through our novel electrode architecture that significantly enhances the quality and reliability of recorded brain signals. We introduce ....A novel platform-technology for long-term subcutaneous neurophysiology. This project aims to develop a novel miniature device for subcutaneous and tetherless brain sensing. It addresses the lack of a device solution for brain-sensing that combines ultra-long-term reliable sensing capability and small dimensions for minimally-invasive procedures. We achieve this through our novel electrode architecture that significantly enhances the quality and reliability of recorded brain signals. We introduce a platform technology designed for subscalp anatomy with future use in various brain-machine interfacing applications relying on reliable, long-term and easy-to-implant systems. This project's device manufacturing, training, and intellectual property are expected to strengthen Australia's position in bioelectronics.Read moreRead less
The combined use of proteomics and small molecules for target identification and pathway analysis. This project intends to investigate how a series of new small molecules identified from our research to improve the metabolic effects of insulin. This project will integrate medicinal chemistry with proteomics and metabolic biology to identify the cellular targets and their mechanism of action.
Developing the basis for an quality control platform for human pluripotent stem cells and their differentiated derivatives. Biophotonic techniques based on spectroscopy have the potential to provide low-cost, automatable measurements for the quality control of stem and differentiated cells produced for use in industry and regenerative medicine. This project is aimed at acquiring the fundamental scientific knowledge base required to bring this about.
Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagn ....Microfluidic Separation Science: Innovative Technology for Characterising Complex Chemical Systems. At present there is a need for fast and detailed chemical analysis of complex samples, such as those important to biomedical diagnostics and forensic science. Innovative technology will be developed here in order to reduce analysis time whilst maintaining the integrity of the chemical information contained within the sample. This step change in separation science will directly aid biomedical diagnostics, forensic sample determination and industrial process monitoring through decreased analysis time with an increase in the chemical information gained. By performing chemical separations on a microfluidic scale a reduction in both the cost of analysis and impact of solvent waste on the environment will be achieved.Read moreRead less