Circuit-based monitoring and characterisation of high performance semiconductor processes. As a frontier technology, this project extends Australia's leadership in wireless communications. Potentially this project provides the key enabling method for integrated circuits to take full advantage of future generations of semiconductor technology. National Research Priorities safeguarding Australia and promoting and maintaining good health will also be impacted through more capable circuits for def ....Circuit-based monitoring and characterisation of high performance semiconductor processes. As a frontier technology, this project extends Australia's leadership in wireless communications. Potentially this project provides the key enabling method for integrated circuits to take full advantage of future generations of semiconductor technology. National Research Priorities safeguarding Australia and promoting and maintaining good health will also be impacted through more capable circuits for defence electronics and anti-terrorism, medical remote sensing and networking. The innovations here will make Sapphicon, Australia's only commercial integrated circuit manufacturer, more competitive and indirectly benefit National ICT Australia (NICTA), Commonwealth Scientific and Industrial Research Organisation (CSIRO), Defence Science and Technology Organisation (DSTO), the National Broadband Network and a host of other high-performance electronics concerns.Read moreRead less
Advanced Hybrid Fibres for Functional Biomedical Imaging. This project expects to develop new techniques and devices for biomedical imaging. Biomedical imaging is widely used for medical diagnosis and treatment, with different types of imaging providing different information. This project aims to develop techniques that will allow imaging using safer nonionising terahertz radiation, with better resolution than ever before. It plans to combine this with optical, visible and infrared imaging to gi ....Advanced Hybrid Fibres for Functional Biomedical Imaging. This project expects to develop new techniques and devices for biomedical imaging. Biomedical imaging is widely used for medical diagnosis and treatment, with different types of imaging providing different information. This project aims to develop techniques that will allow imaging using safer nonionising terahertz radiation, with better resolution than ever before. It plans to combine this with optical, visible and infrared imaging to give very broad spectral information. It also aims to develop probes for direct interfacing to tissue to collect and deliver electrical signals, light and fluids, and to image neural activity. The intended outcome of the project is to allow single cancer cells within tissue to be identified to allow early stage cancer detection, and to develop implantable devices for neuroscience research and pain management.Read moreRead less
Interaction of light with tissues: A hyper-spectral approach . This project aims to address an important problem of noncontact assessment of tissue including skin and cartilage. By using extremely wide spectrum – between the terahertz and the near infrared – the effects of scattering and absorption arising from the variation of tissue properties from macro- to nano-scale will be explored. Spatial variations of tissue properties will be addressed in model and experiment by combining spectroscopy ....Interaction of light with tissues: A hyper-spectral approach . This project aims to address an important problem of noncontact assessment of tissue including skin and cartilage. By using extremely wide spectrum – between the terahertz and the near infrared – the effects of scattering and absorption arising from the variation of tissue properties from macro- to nano-scale will be explored. Spatial variations of tissue properties will be addressed in model and experiment by combining spectroscopy with the novel terahertz and mid-infrared Scanning Near field Optical Microscopy. The outcomes will advance fundamental understanding of light interaction with multi-layered tissues. This will provide a tool for advancing bioengineering research, terahertz technology, and development in biomedical devices.Read moreRead less
Sampling and processing for diffusion magnetic resonance imaging. This project aims to develop optimal, efficient and robust signal processing methods for diffusion magnetic resonance imaging (dMRI) with reduced scan times. A child, possibly distressed, can only be motionless long enough to undergo a basic dMRI scan of the brain, but enhanced forms of dMRI need at least 60 minutes. The project’s processing methods will use spherical geometries, which encode information about white matter fibres ....Sampling and processing for diffusion magnetic resonance imaging. This project aims to develop optimal, efficient and robust signal processing methods for diffusion magnetic resonance imaging (dMRI) with reduced scan times. A child, possibly distressed, can only be motionless long enough to undergo a basic dMRI scan of the brain, but enhanced forms of dMRI need at least 60 minutes. The project’s processing methods will use spherical geometries, which encode information about white matter fibres in the brain, to collect and reconstruct images. The project is expected to reduce dMRI scan times and ultimately make non-invasive and inexpensive early detection of neurological disorders such as dementia feasible.Read moreRead less
Interrogating protein hydration by terahertz time-domain spectroscopy. Interrogating protein hydration by terahertz time-domain spectroscopy. This project aims to develop advanced terahertz time-domain spectroscopy (THz-TDS) techniques to understand how a protein’s interaction with excipients in solution can alter the hydration layers around them and how this affects properties such as viscosity and stability. THz-TDS can detect overlapping extended hydration layers around proteins, revealing ne ....Interrogating protein hydration by terahertz time-domain spectroscopy. Interrogating protein hydration by terahertz time-domain spectroscopy. This project aims to develop advanced terahertz time-domain spectroscopy (THz-TDS) techniques to understand how a protein’s interaction with excipients in solution can alter the hydration layers around them and how this affects properties such as viscosity and stability. THz-TDS can detect overlapping extended hydration layers around proteins, revealing new knowledge in protein-protein interactions and protein behaviour in an aqueous environment. The intended outcome is to use THz-TDS to better understand how proteins such as monoclonal antibodies interact in high concentration solutions, and in doing so make better medicines.Read moreRead less
Ultra-fast serialised all optical image processing: addressing the electronic bottleneck in the world's fastest camera. Serial time encoded amplified microscopy can capture over a million frames per second. At this rate, a megapixel image would fill a terabyte hard disk in a second. We will use photonics to condense and manipulated the video stream so that only the important features are 'seen', making it practical to process and store on a computer.
Spectral analysis with selective harmonic emphasis. This project lies under ARC research priority area "Frontier Technologies for Building and Transforming Australian Industries". The signal processing algorithms to be developed in this project will be useful in many important practical applications, which include various bio-medical imaging modalities, beamforming, radar, sonar and target tracking using sensor arrays. The idea is to use the prior knowledge to enhance certain desired properties ....Spectral analysis with selective harmonic emphasis. This project lies under ARC research priority area "Frontier Technologies for Building and Transforming Australian Industries". The signal processing algorithms to be developed in this project will be useful in many important practical applications, which include various bio-medical imaging modalities, beamforming, radar, sonar and target tracking using sensor arrays. The idea is to use the prior knowledge to enhance certain desired properties of the algorithms via intelligent processing. In this light the project also lies within the ARC research priority area of "Smart Information use".Read moreRead less
Advanced biosensing in the terahertz (THz) sub-wavelength regime. This project will build on Australian excellence in photonics, exploiting the advanced use of T-rays for sensing of biological substances such as proteins and DNA. For the first time, this will enable contactless automated sensing for high-speed medical screening of diseases, a critical step toward the ultimate vision of customised medicine.
Continuous wave excitation for low power Magnetic Resonance Imaging. This project aims to augment the capabilities of Magnetic Resonance Imaging (MRI) systems, using continuous wave (CW) transmission and signal reception, to image objects using very low excitation power. Any given MRI sequence tries to solve an inverse problem, involving estimation of some subset of hidden states and parameters of the system, given the observed data. Using transient and steady-state CW magnetisation dynamics to ....Continuous wave excitation for low power Magnetic Resonance Imaging. This project aims to augment the capabilities of Magnetic Resonance Imaging (MRI) systems, using continuous wave (CW) transmission and signal reception, to image objects using very low excitation power. Any given MRI sequence tries to solve an inverse problem, involving estimation of some subset of hidden states and parameters of the system, given the observed data. Using transient and steady-state CW magnetisation dynamics to solve inverse problems is expected to advance technology toward lower power, lower cost solutions for MRI scanners in healthcare and industrial applications, including materials science and mineral processing.Read moreRead less
Signal processing algorithms for interpreting multi-dimensional ambulatory data during normal activities: correlates of current measures of fall risk. This project will develop algorithms to analyse human movement, measured using a small waist-worn sensor, which approximate existing clinical tests to identify likely fallers. This will enable future fall risk monitor development. This is an important problem as one in three senior citizens fall each year, costing around $500 million in healthcare ....Signal processing algorithms for interpreting multi-dimensional ambulatory data during normal activities: correlates of current measures of fall risk. This project will develop algorithms to analyse human movement, measured using a small waist-worn sensor, which approximate existing clinical tests to identify likely fallers. This will enable future fall risk monitor development. This is an important problem as one in three senior citizens fall each year, costing around $500 million in healthcare.Read moreRead less