Probing the function of protein molecular motors on nano-fabricated structures. The function of protein linear molecular motors, which are natural dynamic bio-nano-devices with a ubiquitous importance in multicellular organisms, will be 'probed' with purposefully designed nano-structures fabricated via photo- or Scanning Probe Microscopy Lithography, that is, flat polymeric surfaces with combinatorial combinations of physico-chemistries; and micro/nano-channels and nano-wells with critical dimen ....Probing the function of protein molecular motors on nano-fabricated structures. The function of protein linear molecular motors, which are natural dynamic bio-nano-devices with a ubiquitous importance in multicellular organisms, will be 'probed' with purposefully designed nano-structures fabricated via photo- or Scanning Probe Microscopy Lithography, that is, flat polymeric surfaces with combinatorial combinations of physico-chemistries; and micro/nano-channels and nano-wells with critical dimensions similar to the scale of the probed biomolecules. The project turns 'up-side down' the challenge of invasive nano-probing of biomolecules using it in an engineered manner. The fundamental understanding of linear molecular motors will impact on biomedical science and on the assessment of hybrid natural-artificial dynamic nano-devices.Read moreRead less
Microfibre photonics: function densification on a wavelength scale. The project will contribute to Australia's nanoscale device research and nanomanufacturing development. The project will create microfibre fabrication technologies for the creation of new optical systems of miniature proportions that will be used for cell illumination, for the creation of sensors for detection in small environments and as light tools for fundamental experiments in physics. Specialist fabrication methods will be ....Microfibre photonics: function densification on a wavelength scale. The project will contribute to Australia's nanoscale device research and nanomanufacturing development. The project will create microfibre fabrication technologies for the creation of new optical systems of miniature proportions that will be used for cell illumination, for the creation of sensors for detection in small environments and as light tools for fundamental experiments in physics. Specialist fabrication methods will be developed that will add to the nation's skill base. The outcomes of the project will enhance Australia's knowledge capacity, research capability and will contribute significantly to each of the National Research Priorities.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100810
Funder
Australian Research Council
Funding Amount
$343,450.00
Summary
Optical tweezers for bio-nanotechnologies. This project aims to develop a platform of diamond nanosensors and novel optical tweezers for probing cellular processes with single-molecule resolution, in vivo and over physiologically relevant time scales. In biomedicine, long-term imaging of single-molecules is beyond reach with existing bio-labels. The project combines the superior properties of nanodiamond biomarkers (brightness, stability, small size and non-toxicity), with new optical tweezers w ....Optical tweezers for bio-nanotechnologies. This project aims to develop a platform of diamond nanosensors and novel optical tweezers for probing cellular processes with single-molecule resolution, in vivo and over physiologically relevant time scales. In biomedicine, long-term imaging of single-molecules is beyond reach with existing bio-labels. The project combines the superior properties of nanodiamond biomarkers (brightness, stability, small size and non-toxicity), with new optical tweezers which exploit laser trapping of atoms to manipulate nanodiamonds in three-dimensional biological environments. By accessing smaller size and higher force regimes, the platform will improve bio-imaging and bio-manipulation techniques, and potentially advance pathogentracking and early detection of diseases.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100040
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this ....ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this Hub include advanced manufacturing capacity for connected sensors, strategic partnerships and commercialisation skills to translate sensors research to create economic benefits such as jobs and locally-made products for domestic and export markets, as well as improving the health of Australians.Read moreRead less
Biomedical imaging with spins in nanoparticles: from single cell to whole-body scanning. The engineering of new biomedical technology is critical in underpinning our understanding of physiology and in the early detection of disease. This project will construct novel instrumentation for investigating normal and diseased physiology using bioagents based on diamond and ruby nanoparticles. The imaging and tracking techniques proposed are non-invasive, nontoxic, and provide high-resolution access to ....Biomedical imaging with spins in nanoparticles: from single cell to whole-body scanning. The engineering of new biomedical technology is critical in underpinning our understanding of physiology and in the early detection of disease. This project will construct novel instrumentation for investigating normal and diseased physiology using bioagents based on diamond and ruby nanoparticles. The imaging and tracking techniques proposed are non-invasive, nontoxic, and provide high-resolution access to specific physiological interactions of paramount importance in, for instance, understanding cancer pathways and developing strategies for targeted drug delivery.Read moreRead less
Rapid Pathogen Detection using Super-Sensitive Multiplexing Nanophotonic Probes. Responding to an urgent need to advance rapid molecular diagnostics, this project aims to explore new photonics and biochemistry approaches to DNA recognition. It is anchored on proprietary light-emitting nanodots which have single-molecule sensitivity in conjunction with tunable optical identities. The project aims to develop a multiplexing reagent library of DNA probes to sense trace DNA molecules and to recognise ....Rapid Pathogen Detection using Super-Sensitive Multiplexing Nanophotonic Probes. Responding to an urgent need to advance rapid molecular diagnostics, this project aims to explore new photonics and biochemistry approaches to DNA recognition. It is anchored on proprietary light-emitting nanodots which have single-molecule sensitivity in conjunction with tunable optical identities. The project aims to develop a multiplexing reagent library of DNA probes to sense trace DNA molecules and to recognise multiple pathogens in a single assay. This innovation aims to create a hybrid-Polymerase Chain Reaction (PCR) technology platform for current industry-standard pathogen detection tests. The outcomes of the project aim to enable DNA based pathogen diagnostics within 90 minutes, four times faster than the current tests.Read moreRead less
Protein Structural-Dynamics at Solid Surfaces: Beyond Static Snapshots. The project will use High-Speed Atomic Force Microscopy to directly visualize single proteins in ‘action’ with surfaces, revealing their dynamics at unprecedented combined structural and temporal resolution in liquid. Such characterization moves beyond static ‘snapshots’ of protein structure, toward the dynamic changes in protein conformation that will enable new exploration of key biological processes at liquid-solid interf ....Protein Structural-Dynamics at Solid Surfaces: Beyond Static Snapshots. The project will use High-Speed Atomic Force Microscopy to directly visualize single proteins in ‘action’ with surfaces, revealing their dynamics at unprecedented combined structural and temporal resolution in liquid. Such characterization moves beyond static ‘snapshots’ of protein structure, toward the dynamic changes in protein conformation that will enable new exploration of key biological processes at liquid-solid interfaces. New fundamental discoveries will have an impact on technologies such as medical device coatings, biomaterials, biosensors, microfluidics devices, protein purification and diagnostics assays that are critically dependent on the biological function of adsorbed or immobilized proteins.Read moreRead less
A nanoengineered solution to drug delivery in bone. This project presents an exciting new approach of applying nanotechnology to bone research. By combining our expertise in nanoengineering of new materials, mathematical modelling and bone biology, this project will result in a well-characterised model for drug delivery into bone and lead to a new therapeutic approach for treating bone diseases.
Discovery Early Career Researcher Award - Grant ID: DE140100549
Funder
Australian Research Council
Funding Amount
$373,220.00
Summary
Stratiform Optical Barcoding System for Cardiac Biomarkers: Towards Smart Computerised Clinical Prognosis of Cardiovascular Disease. This project involves the development of an innovative optical biosensing system combined with a sophisticated barcode system containing information for clinical diagnosis of cardiovascular disease. For the first time, this system will provide information on the amount and chemical structure of cardiac biomarkers at the same time by combining reflectometric interfe ....Stratiform Optical Barcoding System for Cardiac Biomarkers: Towards Smart Computerised Clinical Prognosis of Cardiovascular Disease. This project involves the development of an innovative optical biosensing system combined with a sophisticated barcode system containing information for clinical diagnosis of cardiovascular disease. For the first time, this system will provide information on the amount and chemical structure of cardiac biomarkers at the same time by combining reflectometric interference and low resolution Raman spectroscopies. These optical signals will be converted into barcodes containing several levels of information, which will be at the base of this versatile point-of-care test. The obtained results will be implemented in a computerised database to improve current cardiac disease diagnosis.Read moreRead less
Soft carbon nanotube materials. There is no doubt that the realisation of new bionic materials will dramatically improve quality of life for many individuals. The new soft conducting materials proposed will impact on several areas of bionics, including the development of the next generation Bionic Ear, conduits for spinal cord regeneration as well as muscle regeneration and other applications. This project will further enhance the international profile of the ARC Centre of Excellence for Electro ....Soft carbon nanotube materials. There is no doubt that the realisation of new bionic materials will dramatically improve quality of life for many individuals. The new soft conducting materials proposed will impact on several areas of bionics, including the development of the next generation Bionic Ear, conduits for spinal cord regeneration as well as muscle regeneration and other applications. This project will further enhance the international profile of the ARC Centre of Excellence for Electromaterials Science in the field of Bionics. The end-user network already in place will ensure all opportunities are fully exploited.Read moreRead less