Membrane structure and lipid interactions of the pore-forming toxin Equinatoxin II by NMR. The structure of Equinatoxin II, a pore-forming protein, will be determined in model cell membranes using solid-state NMR spectroscopy. The relationship of molecular structure to bioactivity and the nature of the pore-forming mechanism of this toxin will be determined. The results will aid in understanding how toxins lyse cells and could lead to the design of improved antibiotic peptides. Currently the st ....Membrane structure and lipid interactions of the pore-forming toxin Equinatoxin II by NMR. The structure of Equinatoxin II, a pore-forming protein, will be determined in model cell membranes using solid-state NMR spectroscopy. The relationship of molecular structure to bioactivity and the nature of the pore-forming mechanism of this toxin will be determined. The results will aid in understanding how toxins lyse cells and could lead to the design of improved antibiotic peptides. Currently the structure of membrane proteins are difficult to determine and the newly developed techniques used for the structural determination of this membrane-associated protein will be suitable for studying other membrane proteins and receptors of pharmaceutical importance.Read moreRead less
Advanced technologies for laser refractive surgery. People who wear glasses can now undergo laser eye-surgery to correct their focussing problems. While many can ?throw away their glasses?, the results are optimised for one viewing situation so that when people move their eyes or refocus, visual clarity is not perfect. We need precise measurements of the eye's shape under dynamic conditions to understand exactly how optical distortions (aberrations) affect clarity of sight. This project is to b ....Advanced technologies for laser refractive surgery. People who wear glasses can now undergo laser eye-surgery to correct their focussing problems. While many can ?throw away their glasses?, the results are optimised for one viewing situation so that when people move their eyes or refocus, visual clarity is not perfect. We need precise measurements of the eye's shape under dynamic conditions to understand exactly how optical distortions (aberrations) affect clarity of sight. This project is to build a laser device that incorporates a deformable mirror to investigate the interplay between aberrations and visual clarity. This new knowledge is a vital next step to improve laser eye-surgery success.Read moreRead less
Paper fluidics - A novel approach to low cost printable microsensors. Printing is perhaps the cheapest means of mass production available, yet it is used almost exclusively to mass produce only one thing, i.e. the printed word! This project will enable the development of disposable printed sensors for assessing the quality of water or the health of an individual. Sensors are generally relatively expensive, but the ability to print them on paper by the thousand will bring down the cost to a few ....Paper fluidics - A novel approach to low cost printable microsensors. Printing is perhaps the cheapest means of mass production available, yet it is used almost exclusively to mass produce only one thing, i.e. the printed word! This project will enable the development of disposable printed sensors for assessing the quality of water or the health of an individual. Sensors are generally relatively expensive, but the ability to print them on paper by the thousand will bring down the cost to a few cents. Such cheap, portable, easy-to-use sensors if widely available could profoundly affect the lives of people living in remote areas and developing countries.Read moreRead less
ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membra ....ARC Centre of Excellence - Coherent X-ray Science. The twenty first century is said to be the century of biology. And there is no doubt that the development of our understanding of biological system is continuing at a massive rate. However as our understanding deepens, we need to draw on the whole range of scientific disciplines to proceed. This Centre draws together a multidisciplinary team of world-leading scientists to address one the key questions in modern biology, the structure of a membrane protein. We will develop techniques based on the latest developments in theoretical physics & chemistry, imaging, biology and technology - including the new Australian Synchrotron - to create new approaches to structural biology.Read moreRead less
From Nanosecond Timing to Nanohertz Gravitational Wave Detection. Radio pulsars are the collapsed cores of once-massive stars that are renowned for their exceptional rotational stability. Ever since their discovery Australia has played a prominent role in the discovery and monitoring of these enigmatic sources. The timing and discovery of millisecond pulsars is an area where Australia is a world leader. This programme will use a powerful new instrument on the Parkes radio telescope to search for ....From Nanosecond Timing to Nanohertz Gravitational Wave Detection. Radio pulsars are the collapsed cores of once-massive stars that are renowned for their exceptional rotational stability. Ever since their discovery Australia has played a prominent role in the discovery and monitoring of these enigmatic sources. The timing and discovery of millisecond pulsars is an area where Australia is a world leader. This programme will use a powerful new instrument on the Parkes radio telescope to search for the minute influence of gravitational waves from supermassive black hole binaries on the millisecond pulsars.Read moreRead less
New Pulsar Instrumentation for Gravitation Wave Detection and Understanding the Emission Mechanism. Millisecond pulsar timing currently provides the most sensitive method of detecting long-period gravitational waves which permeate the Universe. Parkes leads the world in the discovery and timing of millisecond pulsars. This has motivated the development of three new advanced instruments including a cyrogenic dual-band receiver, a very wide-band correlator and a baseband recorder with an in-built ....New Pulsar Instrumentation for Gravitation Wave Detection and Understanding the Emission Mechanism. Millisecond pulsar timing currently provides the most sensitive method of detecting long-period gravitational waves which permeate the Universe. Parkes leads the world in the discovery and timing of millisecond pulsars. This has motivated the development of three new advanced instruments including a cyrogenic dual-band receiver, a very wide-band correlator and a baseband recorder with an in-built supercomputer. We aim to exploit these new technologies to systematically study the pulsar population. We will establish a timing array which can detect gravitational waves, enable GLAST to identify over 100 gamma-ray pulsars and study the pulsar emission mechanism at sub-microsecond time resolution.
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Spectroscopy of complex and biological micro-objects for biosensing applications. The optically based test for specific DNA binding resulting from the conclusion of this project is of great potential benefit to all Australians as DNA is the building block of all living organisms. The technique developed and resulting biosensor will provide an invaluable tool for the determination and analysis of specific DNA reactions. The general technique developed for the genetic targeting of specific DNA rea ....Spectroscopy of complex and biological micro-objects for biosensing applications. The optically based test for specific DNA binding resulting from the conclusion of this project is of great potential benefit to all Australians as DNA is the building block of all living organisms. The technique developed and resulting biosensor will provide an invaluable tool for the determination and analysis of specific DNA reactions. The general technique developed for the genetic targeting of specific DNA reactions makes the detection of diseases and toxins like Chlamydia and anthrax, for example cheap, quick and accurate, keeping Australian's healthy, and strengthening national security.Read moreRead less
Design and Construction of Novel Thermal Interferometers. This project aims to invent thermal interferometers, which take advantage of the interference effect of thermal waves to display standing temperature interference fringes on a surface of prism. Two coherent thermal waves are input from two other surfaces of the prism in a similar way as an optical interferometer does. By inventing such a device, the project will demonstrate a new instrumentation mechanism which may lead to its applicati ....Design and Construction of Novel Thermal Interferometers. This project aims to invent thermal interferometers, which take advantage of the interference effect of thermal waves to display standing temperature interference fringes on a surface of prism. Two coherent thermal waves are input from two other surfaces of the prism in a similar way as an optical interferometer does. By inventing such a device, the project will demonstrate a new instrumentation mechanism which may lead to its application in medical technology. Furthermore, the principle of temperature localisation due to thermal interference may provide new insights to account for the cause of conformational changes of proteins that result in diseases.Read moreRead less
Special Research Initiatives - Grant ID: SR0354636
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
Australian Computational Molecular Science Network. Computational Molecular Science (CMS) involves the use of theory and computational methods to simulate and visualise molecular systems ranging from small atmospheric species to proteins, nucleic acids, chemical polymers and materials. It represents our most incisive expression of what we understand about the molecular basis of nature. The CMS network will integrate and cross-fertilize both fundamental and application-based expertize in molecula ....Australian Computational Molecular Science Network. Computational Molecular Science (CMS) involves the use of theory and computational methods to simulate and visualise molecular systems ranging from small atmospheric species to proteins, nucleic acids, chemical polymers and materials. It represents our most incisive expression of what we understand about the molecular basis of nature. The CMS network will integrate and cross-fertilize both fundamental and application-based expertize in molecular scale computations in the fields of nanoscience, biomaterials, biotechnology, biomedical science and environmental science. It will uncover and explore critical new interdisciplinary science and create new molecular-based paradigms that will drive advances in these fields over the next decade.Read moreRead less
Special Research Initiatives - Grant ID: SR0354604
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Network in Imaging Science and Technology. The ARC Network in Imaging Science and Technology is a field of research network covering the fundamental science and technological development of applied imaging systems. The network will encompass all aspects of the imaging sciences from image formation, through image processing and analysis, and on to image visualisation. In particular, the network will focus on a number of application areas that utilise these core technologies: medical imaging; ....ARC Network in Imaging Science and Technology. The ARC Network in Imaging Science and Technology is a field of research network covering the fundamental science and technological development of applied imaging systems. The network will encompass all aspects of the imaging sciences from image formation, through image processing and analysis, and on to image visualisation. In particular, the network will focus on a number of application areas that utilise these core technologies: medical imaging; surveillance and security; materials science and metallurgy; environmental monitoring; and consumer imaging. In this way, the network will provide an environment for creative inter-disciplinary research to the socio-economic benefit of Australia.Read moreRead less