Understanding Tendon Response to Sport and Exercise: Implications for Optimising Training, Injury Prevention and Accelerated Rehabilitation. This research will use frontier technologies to establish the effect of physical activity on tendon adaptation and injury. It will address National Research Priorities and lead to contemporary evidence-based physical activity practices to optimise health and fitness, prevent injury, and expedite rehabilitation after injury. Given the significant national in ....Understanding Tendon Response to Sport and Exercise: Implications for Optimising Training, Injury Prevention and Accelerated Rehabilitation. This research will use frontier technologies to establish the effect of physical activity on tendon adaptation and injury. It will address National Research Priorities and lead to contemporary evidence-based physical activity practices to optimise health and fitness, prevent injury, and expedite rehabilitation after injury. Given the significant national investment in sport, the rise in obesity, and the immense cost of sedentary behaviour and sport-related injuries, this research will have applications for enhancing physical activity recommendations that maintain health for all Australians. It will enhance Australia's leading position in international sport and sport science research and have beneficial applications for occupational health.Read moreRead less
Citizen engagement: Listening to citizens' views about Australia's health system and prevention. This project will yield new and important perspectives from citizens on preventive health and health promotion, which can be used to develop better targeted and more effective prevention and promotion policies and strategies. Citizens views will be investigated in relation to vexed issues such as: new approaches to financing and program delivery, reorienting the health insurance sector, reorienting ....Citizen engagement: Listening to citizens' views about Australia's health system and prevention. This project will yield new and important perspectives from citizens on preventive health and health promotion, which can be used to develop better targeted and more effective prevention and promotion policies and strategies. Citizens views will be investigated in relation to vexed issues such as: new approaches to financing and program delivery, reorienting the health insurance sector, reorienting the health system to focus more on prevention and health promotion, improving current approaches of consumer participation in prevention and chronic disease management, tackling broader issues in public policy trade-offs between health and non-health, diversifying workforce roles and involving health professionals in prevention and promotion.Read moreRead less
Long term economic impacts of disease on older workers to 2030: Costs to government and individuals and opportunities for intervention. This project will fill substantial gaps in Australian evidence about the health conditions of the future that will keep older workers out of the labour market and diminish their own immediate and long-term livings standards, thereby reducing funds available to government. We will address one of the most significant issues resulting from the fundamental changes t ....Long term economic impacts of disease on older workers to 2030: Costs to government and individuals and opportunities for intervention. This project will fill substantial gaps in Australian evidence about the health conditions of the future that will keep older workers out of the labour market and diminish their own immediate and long-term livings standards, thereby reducing funds available to government. We will address one of the most significant issues resulting from the fundamental changes to the demography of the Australian labour market and one that is regularly raised by the government following the release of the 2002 and 2007 Intergenerational Reports. This project will also examine the interventions that would improve the health of older workers and increase labour force participation over the long term.Read moreRead less
Planning female and male vaccination and cervical screening strategies to achieve optimal prevention of HPV-related disease. The findings from this research will inform the development of public health policy on the most cost-effective utilisation of resources for preventing cervical, anogenital and head/neck cancers, and genital warts, in women and men, due to human papillomavirus (HPV). We will evaluate strategies for using emerging screening and vaccine technologies to prevent HPV-related dis ....Planning female and male vaccination and cervical screening strategies to achieve optimal prevention of HPV-related disease. The findings from this research will inform the development of public health policy on the most cost-effective utilisation of resources for preventing cervical, anogenital and head/neck cancers, and genital warts, in women and men, due to human papillomavirus (HPV). We will evaluate strategies for using emerging screening and vaccine technologies to prevent HPV-related disease, and assess potential adverse outcomes of vaccination. Men are currently not covered by routine vaccination or screening programs; this research will assess the benefit to men of vaccinating women only, and will consider the impact of vaccination and other interventions targeted towards men.Read moreRead less
Tracking the musculoskeletal health and performance of talented adolescent female athletes. The vision is to gain an innovative understanding of risk factors for the early detection or prevention of injury, and to identify factors that promote participation longevity in young athletes. The biomechanics explored in this study will provide a basis for larger studies in future years. Large economic and social benefits can be gained from increased knowledge of injury prevention early in life. Lowere ....Tracking the musculoskeletal health and performance of talented adolescent female athletes. The vision is to gain an innovative understanding of risk factors for the early detection or prevention of injury, and to identify factors that promote participation longevity in young athletes. The biomechanics explored in this study will provide a basis for larger studies in future years. Large economic and social benefits can be gained from increased knowledge of injury prevention early in life. Lowered injury costs provide immediate cost benefits to the nation. Ultimately, in a nation familiar with the high costs of cardiovascular and musculoskeletal diseases, the health sector of Australia will be the greatest benefactor of this project.Read moreRead less
Treating Equine Laminitis. This project aims to explore the causes of equine laminitis, and to work with a newly-established Australian biopharma company to develop the world's first anti-laminitis medication. Equine laminitis is a painful, crippling disease of the foot, often necessitating euthanasia, and is the second-most common cause of death in domestic horses. In 2007, a landmark study identified insulin toxicity as a primary cause of laminitis, and subsequent research has identified over- ....Treating Equine Laminitis. This project aims to explore the causes of equine laminitis, and to work with a newly-established Australian biopharma company to develop the world's first anti-laminitis medication. Equine laminitis is a painful, crippling disease of the foot, often necessitating euthanasia, and is the second-most common cause of death in domestic horses. In 2007, a landmark study identified insulin toxicity as a primary cause of laminitis, and subsequent research has identified over-stimulation of the IGF-1 receptor as the most likely mechanism. This project aims to prove that mechanism and to develop an effective treatment.Read moreRead less
Development of dense gas technology platforms for the formulation of oral vaccines. This project will aim to develop a technology platform that enables the formulation of vaccines that can be delivered orally and this research has the potential to radically change existing vaccination regimens. The availability of needle-free vaccination also has potential for considerable societal and economic impact in developing countries.
A new approach to reversing and preventing immune-mediated diseases. Chronic inflammatory diseases affect up to 20 per cent of Australians. These diseases reduce wellbeing and life potential and shorten lifespan. This project addresses the urgent need for effective therapies and focuses on developing strategies for disease cure and prevention.
Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application i ....Mechanosensitive properties and modulation of N-methyl-D-aspartate (NMDA) receptors by lipid environment. This project will provide new information about the molecular determinants which influence NMDA receptor channel gating that will significantly advance our understanding of a link between NMDA receptor function and many neurodegenerative diseases as well as pain and learning and memory. The outcomes of this project may lead to the discovery of novel lipid-based biomaterials for application in medicine and the drug industry. This research is highly significant in relation to human health. The biological and nutritional aspects of polyunsaturated lipids and dietary fish oils have long been recognized. Thus this project will provide further knowledge that could benefit the health of the nation with consequent reduced health care costs.Read moreRead less
Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines. Steroidal saponins are a class of natural products that are common constituents of many herbal medicines and have been associated with many biological activities. Comprehensive studies into their biological activities are hampered by the small quantities available through isolation and the complexity of synthesis. The aim of this project is to identify, isolate and express the biosynthetic genes responsible ....Bioproduction and bioavailability of steroidal saponins, bioactives in herbal medicines. Steroidal saponins are a class of natural products that are common constituents of many herbal medicines and have been associated with many biological activities. Comprehensive studies into their biological activities are hampered by the small quantities available through isolation and the complexity of synthesis. The aim of this project is to identify, isolate and express the biosynthetic genes responsible for the critical steps in the synthesis of these compounds in the herbs themselves. This will allow for production of steroidal saponins using the isolated enzymes, facilitate biological studies and allow the production of critical standards required by the herbal industry for validation and regulation of herbal extracts.Read moreRead less