Highly Efficient Nanomotors for Autonomous Cell Recognition and Isolation. This project aims to develop next-generation self-driven nanomotors capable of long-range motion with highly controlled directionality for cell recognition, transportation and separation in complex biological environments, to allow autonomous and seamless cell sorting with high accuracy. The anticipated goal of this project is to advance the field of nanotechnology and advanced manufacturing with potential to support new ....Highly Efficient Nanomotors for Autonomous Cell Recognition and Isolation. This project aims to develop next-generation self-driven nanomotors capable of long-range motion with highly controlled directionality for cell recognition, transportation and separation in complex biological environments, to allow autonomous and seamless cell sorting with high accuracy. The anticipated goal of this project is to advance the field of nanotechnology and advanced manufacturing with potential to support new applications and to value-add Australia’s advanced manufacturing industry, presenting new opportunities for Australian MedTech industries with innovative, disruptive technologies to address its unique needs and to claim Australia’s position within the competitive global market.Read moreRead less
Ultrathin membranes of novel structures for highly efficient water reuse. This project aims to develop a new generation of reverse osmosis membranes to enable significantly more efficient water reuse. The project expects to generate new knowledge in the area of membrane technology and wastewater reclamation using innovative designs of membrane structures and new techniques for membrane synthesis. Expected outcomes of the project include the development of highly permeable and high selective reve ....Ultrathin membranes of novel structures for highly efficient water reuse. This project aims to develop a new generation of reverse osmosis membranes to enable significantly more efficient water reuse. The project expects to generate new knowledge in the area of membrane technology and wastewater reclamation using innovative designs of membrane structures and new techniques for membrane synthesis. Expected outcomes of the project include the development of highly permeable and high selective reverse osmosis membranes. This project should provide significant benefits to water reuse by greatly improving product water quality and dramatically reducing its energy consumption by over 50 per cent, which in turn addresses the challenges of water scarcity and water-energy nexus.Read moreRead less
Determination of cellular mechanisms underpinning cancer cell metastasis through integrated in vivo imaging approaches. Understanding key steps that drive the spread of cancer is critical to improve current treatment strategies. Using cutting-edge imaging technology and in vivo model systems that mimic the disease, this project will pinpoint key events that are susceptible to drug intervention and identify new therapeutic targets.
Development of Solar-induced, Dark-active Photocatalytic Membranes for Water Disinfection. Stormwater is one of the last freshwater resources that has not been utilised to its full potential. However, large amount of faecal pathogens in stormwater limit its harvesting practice.This project aims at addressing this significant problem by developing the next generation of photocatalytic membranes for stormwater disinfection. The proposed membranes not only are passive water treatment technology whi ....Development of Solar-induced, Dark-active Photocatalytic Membranes for Water Disinfection. Stormwater is one of the last freshwater resources that has not been utilised to its full potential. However, large amount of faecal pathogens in stormwater limit its harvesting practice.This project aims at addressing this significant problem by developing the next generation of photocatalytic membranes for stormwater disinfection. The proposed membranes not only are passive water treatment technology which only utilises solar energy, but also are operated regardless of weather, even at night. The results will provide new insights on development of future water treatment technologies. This project will also raise Australia’s credibility and competitiveness in the water and membrane industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100206
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Lattice light sheet microscopy for imaging biology in real space and time. This project aims to establish a Lattice Light-Sheet Microscope (LLSM) Facility, to provide the dedicated computing infrastructure needed for terabyte-scale image acquisition and handling. Lattice light sheet microscopy allows four-dimensional imaging of live biological specimens from individual molecules to small organisms. The microscope images live specimens without phototoxicity or photobleaching, enabling prolonged i ....Lattice light sheet microscopy for imaging biology in real space and time. This project aims to establish a Lattice Light-Sheet Microscope (LLSM) Facility, to provide the dedicated computing infrastructure needed for terabyte-scale image acquisition and handling. Lattice light sheet microscopy allows four-dimensional imaging of live biological specimens from individual molecules to small organisms. The microscope images live specimens without phototoxicity or photobleaching, enabling prolonged imaging of significant physiological or biophysical events. Expected outcomes include high impact discoveries and publications in fundamental research, rapid solutions for industry-focussed projects and opportunities for collaboration, research and development. The imaging is expected to reveal key scientific insights and showcase biology to the public.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC200100052
Funder
Australian Research Council
Funding Amount
$4,789,838.00
Summary
ARC Training Centre for Cryo-Electron Microscopy of Membrane Proteins for Drug Discovery. This Centre aims to train industry-ready, world class graduates in cryo-electron microscopy of membrane proteins. The Centre’s graduates and research results would enable tomorrow’s industrial expansion in structure-enhanced drug design. Expected outcomes are world-first structural biology knowledge and techniques, and the entrepreneurial and technical skills desired by industry. This should provide signifi ....ARC Training Centre for Cryo-Electron Microscopy of Membrane Proteins for Drug Discovery. This Centre aims to train industry-ready, world class graduates in cryo-electron microscopy of membrane proteins. The Centre’s graduates and research results would enable tomorrow’s industrial expansion in structure-enhanced drug design. Expected outcomes are world-first structural biology knowledge and techniques, and the entrepreneurial and technical skills desired by industry. This should provide significant benefits including advancing Australian biotechnological capacity and improved linkages with major pharmaceutical partners. It should also provide a substantive competitive advantage to nascent Australian biotechnology companies that also links into new National investment into drug discovery and development infrastructure.Read moreRead less
Tuning Molecular Translocaton by Close-Field Electroporation. This project aims to determine the underlying mechanisms by which DNA and other molecules are able to migrate across the cell membrane in response to highly localised electric fields. It has recently been shown that focusing of electric fields at the cellular level, using an array of small electrodes, results in unexpectedly high cell transfection efficiencies. It has been termed 'close-field electroporation'. Here it is proposed t ....Tuning Molecular Translocaton by Close-Field Electroporation. This project aims to determine the underlying mechanisms by which DNA and other molecules are able to migrate across the cell membrane in response to highly localised electric fields. It has recently been shown that focusing of electric fields at the cellular level, using an array of small electrodes, results in unexpectedly high cell transfection efficiencies. It has been termed 'close-field electroporation'. Here it is proposed to establish the properties of the electric fields around cells and cell membrane interactions with these fields that enable molecular translocation. This fundamental science could have broad implications in the domains of drug delivery, gene therapy and neural stimulation.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100189
Funder
Australian Research Council
Funding Amount
$190,000.00
Summary
Integrated magnetic resonance gas and oil analyser. Magnetic resonance has enormous potential in a range of industrial applications. This facility will develop these capabilities and contribute unique insights into liquid and gas transport in systems ranging from rock cores to reverse osmosis membranes used in desalination.