Surveillance Of LGV Chlamydia Trachomatis Types Among Men Who Have Sex With Men (MSM)
Funder
National Health and Medical Research Council
Funding Amount
$194,875.00
Summary
Chlamydia is a common sexually transmitted infection (STI) caused by the bacterium, Chlamydia trachomatis (CT). Annually, 50 million new cases of chlamydia are estimated to occur worldwide which if untreated, can lead to serious complications such as pelvic inflammatory disease and infertility in women and epididymitis in men. Over the past decade, there has been a sharp increase in diagnoses of chlamydia in Australia, coinciding with a reported upsurge in sexual risk behaviour (increased partne ....Chlamydia is a common sexually transmitted infection (STI) caused by the bacterium, Chlamydia trachomatis (CT). Annually, 50 million new cases of chlamydia are estimated to occur worldwide which if untreated, can lead to serious complications such as pelvic inflammatory disease and infertility in women and epididymitis in men. Over the past decade, there has been a sharp increase in diagnoses of chlamydia in Australia, coinciding with a reported upsurge in sexual risk behaviour (increased partner numbers and-or practices of unprotected sex), particularly among men who have sex with men (MSM). In addition, there are current outbreaks of an invasive CT strain, causing lymphogranuloma venereum (LGV), throughout Western Europe, with cases now reported in the USA. LGV can lead to severe anogenital ulcers, which can increase transmission of HIV, hepatitis C, and other STIs. With growing international travel, the likelihood of LGV outbreaks in Australia, particularly in MSM, is increased. Recently, isolated cases of LGV have been noted in MSM attending Sydney and Melbourne Sexual Health Centres, indicating LGV is possibly already in circulation. Since we know little about circulating CT types in Australia it would be difficult to assess the burden of an LGV outbreak. Due to increasing CT infections and likely risk of increased HIV transmission, particularly with LGV strains, surveillance of CT genotypes in Australia, especially in MSM, is important. The purpose of this study is to type CT strains in our population by looking at their genetic makeup. CT-positive specimens from Melbourne and Sydney will be used to identify CT types in circulation and to assess if LGV types are present. The knowledge obtained from this study will be novel and invaluable, and could contribute considerably to the development of improved disease prevention and intervention strategies, including the design of vaccines.Read moreRead less
Effect Of Sex Steroids, Inflammation, Environmental And Biopsychosocial Factors On Cardiometabolic Disease Risk In Men
Funder
National Health and Medical Research Council
Funding Amount
$1,817,271.00
Summary
Heart disease is more frequent and occurs at an earlier age in men than women. The reason is unknown. Apart from obesity and associated disturbances of metabolism, changes in sex hormones such as testosterone, together with the effects of inflammation may be important, and may in turn be affected by environment, lifestyle behaviours, and stress. To untangle these relationships, we will use cutting edge technology, in a large sample of men, in partnership with other international scientists.
Drug using behaviours and beliefs, and associated harms, among gay and bisexual men. Gay and bisexual men have high rates of drug use. This cohort study will contribute to Australia’s response to drug use by identifying: risk factors for, and prevalence and incidence of, drug use and associated harms within this high risk population; the role of gay community norms in individuals' beliefs about and motivations for drug use; and, implications for HIV and HCV infection. The findings will help to b ....Drug using behaviours and beliefs, and associated harms, among gay and bisexual men. Gay and bisexual men have high rates of drug use. This cohort study will contribute to Australia’s response to drug use by identifying: risk factors for, and prevalence and incidence of, drug use and associated harms within this high risk population; the role of gay community norms in individuals' beliefs about and motivations for drug use; and, implications for HIV and HCV infection. The findings will help to better target, educate and support those at risk of drug use and associated harms. Read moreRead less
Selling The Punt: An interdisciplinary analysis of the extent and impact of sports wagering marketing strategies in Australia. Sports wagering is the fastest growing segment of the gambling market in Australia. Despite widespread concern about the impact of marketing strategies on the risky consumption of wagering products by young men and adolescents, research and policy has failed to keep up with this rapidly growing industry. This study will provide: detailed information about the range of ma ....Selling The Punt: An interdisciplinary analysis of the extent and impact of sports wagering marketing strategies in Australia. Sports wagering is the fastest growing segment of the gambling market in Australia. Despite widespread concern about the impact of marketing strategies on the risky consumption of wagering products by young men and adolescents, research and policy has failed to keep up with this rapidly growing industry. This study will provide: detailed information about the range of marketing strategies used to sell sports wagering in Australia; important qualitative insights into the impact of these marketing strategies on gambling behaviours; and, recommendations for a comprehensive public health approach to help counter the potential long and short term risks associated with sports wagering marketing.Read moreRead less
Muscling Up: Australian men, sexualisation and body image enhancment. Australian men are under increasing pressure to appear fit, with psychologists and others identifying body dissatisfaction, depression, and illegal supplement use as evidence of a 'crisis'. However, no research has explored men's emotional and physical investments in injunctions to be 'healthy', or relatively new opportunities in consumer culture for men to style the body. This qualitative project aims to explore men's motivat ....Muscling Up: Australian men, sexualisation and body image enhancment. Australian men are under increasing pressure to appear fit, with psychologists and others identifying body dissatisfaction, depression, and illegal supplement use as evidence of a 'crisis'. However, no research has explored men's emotional and physical investments in injunctions to be 'healthy', or relatively new opportunities in consumer culture for men to style the body. This qualitative project aims to explore men's motivations for engaging in body image-enhancing practices. It expects to provide insight that will benefit those engaged in advocating healthy lifestyles to men.Read moreRead less
Male sex workers and their clients. This project aims to study male sex workers’ relationships with their clients to evaluate how individual agency mitigates risks and dangers. Developments in biomedical HIV prevention can prevent infections but may also change sexual norms and the sexual marketplace for male sex workers and their clients. These changes align with rising rates of crystal methamphetamine use and online technologies in commercial sex encounters. As male sex work changes, a gap exi ....Male sex workers and their clients. This project aims to study male sex workers’ relationships with their clients to evaluate how individual agency mitigates risks and dangers. Developments in biomedical HIV prevention can prevent infections but may also change sexual norms and the sexual marketplace for male sex workers and their clients. These changes align with rising rates of crystal methamphetamine use and online technologies in commercial sex encounters. As male sex work changes, a gap exists in understanding how men negotiate commercial sex encounters. This project expects to inform policies and practices to protect male sex workers’ health and safety, and provide public health information about HIV prevention and illicit drug use in sex work.Read moreRead less
A framework to promote safer practice in commercial sex encounters. The project will address public health needs by producing a framework to promote safer sex practices in commercial sexual encounters involving men, by considering the motivation and practice of those involved. It will also enhance our understanding of masculinity.
Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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Proteomic study of urine to discover novel biomarkers for human prostate cancer. The purpose of this project is to identify novel markers in the urine of patients with prostate cancer. These biomarkers may ultimately prove useful in the development of novel diagnostic tools for the management of this disease.
Role of Musashi in the regulation of cell cycle proteins. We have identified a protein family that directs cell fate and maintains male fertility. This project will provide new avenues for generation of contraceptives in male animals and to regulate stem cells for production of specialised cell types in biotechnological applications.